Induced Resolution of Cavernous Hemangiomas Following Prednisolone Therapy

Zarem, Harvey A.; Edgerton, Milton T.

doi:10.1097/00006534-197302000-00033

Cited by 41 publications

(45 citation statements)

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“…In a study conducted by Dutra (2003), complete cure was found in 59.5% of patients and partial cure in 40.8%. 8 Campos (2000) reported complete and/or partial cure in 84.3% of patients and absence of response to treatment in 13.4% of patients in this study. 6 The fact that in the present study, 38.8% of patients were treated with expectant management is in agreement with other studies in which expectant management was the mode of conduct in 34.9% and 36.4% of cases.…”

Section: Discussionsupporting

confidence: 47%

“…Their principal effect is to halt growth and, if possible, induce regression of the lesion, possibly by inhibiting angiogenesis and inducing apoptosis. 8 Prednisone and prednisolone are the most commonly used oral drugs and doses may vary from 2 to 5 mg/kg/day. Side effects have FIGURE 1: Combined hemangioma in the right genian region been described previously and are generally transitory.…”

Section: Introductionmentioning

confidence: 99%

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Abordagem terapêutica dos hemangiomas cutâneos na infância

A¹,

Soares²,

Júnior³

et al. 2010

An. Bras. Dermatol.

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BACKGROUND: Hemangiomas are benign, self-involuting tumors of endothelial cells that are common in childhood. OBJECTIVES: To evaluate the treatment of 122 patients with skin hemangiomas treated at a teaching hospital in Brasilia, Brazil between March 2000 and December 2006. MATERIAL AND METHODS: Data were collected from the patients' medical records and questionnaires were applied to the children's parents. Variables analyzed were: gender, pre-and perinatal factors, clinical characteristics of the lesions, type of treatment and outcome. RESULTS: A male-to-female ratio of 1.5:1 was found. In 42 patients, hemangiomas were superficial, while in 13 cases they were deep and in 67 patients lesions were mixed. In 7 patients, the lesions were associated with syndromes. In 79 patients, hemangiomas were in the cephalic region. Of the 122 patients, 98 were submitted to one single treatment, while 24 required multiple forms of treatment. In the first group, expectant management was the conduct in 38 patients, compression in 3 cases, systemic corticotherapy in 18 patients, intralesional corticotherapy in 13, topical steroids in 4 cases, conventional surgery in 12 patients, cryosurgery in 7, pulsed light in one case and imiquimod in 2 patients. In the second group of 24 patients submitted to multiple treatment modalities, 15 required two types of treatment and 9 needed three or more. CONCLUSIONS: The data obtained in this study were in agreement with results in the literature with respect to gender and the site of the lesions. The incidence of hemangiomas present at birth was higher than rates published in the literature. The therapeutical results obtained were comparable with data from other published studies. Identification of hemangiomas that require treatment, as well as the right moment for intervention and the best therapeutic option for each case, are factors that need to be taken into consideration. Keywords: corticosteroids; combined therapy; cryosurgery; outcome of therapeutic interventions; general surgery; hemangioma; therapeutics Resumo: FUNDAMENTOS: Hemangioma é um tumor benigno de células endoteliais comum na infância e de involução espontânea. OBJETIVO: Avaliar os tratamentos utilizados em 122 pacientes com hemangiomas cutâ-neos, tratados no Hospital Universitário de Brasília, de março de 2000 a dezembro de 2006. MÉTODOS: Utilizou-se coleta de dados em prontuários e aplicação de questionários aos pais. Foram analisados gênero, fatores pré-natais e perinatais, características clínicas, tipo de tratamento e resultados. RESULTADOS: A razão de sexo (F: M) foi de 1,5:1. 42, em pacientes que apresentavam hemangiomas superficiais, 13 profundos e 67 mistos; em 7 pacientes, havia associação com síndromes. Em 79 pacientes, localizavam-se no polo cefálico. Já em 98/122 dos pacientes, foram submetidos a tratamento único e 24/122 a múltiplos. No primeiro grupo, foi utilizada conduta expectante em 38 pacientes, compressão em 3, corticoide sistêmico em 18, corticoide intralesional em 13, corticoide tópico em 4, cir...

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Abordagem terapêutica dos hemangiomas cutâneos na infância

A¹,

Soares²,

Júnior³

et al. 2010

An. Bras. Dermatol.

View full text Add to dashboard Cite

show abstract

“…In 1967, Zarem and Edgerton reported use of oral prednisone with involution occuring rather quickly in 50-90% of these patients. 11 Intralesional steroid injections of methyl-prednisolone and triamcinolone/betamethasone have been used to induce resolution of hemangiomas. In 1978, Mazzola reported his experience with the treatment of rapidly enlarging mixed strawberry and cavernous haemangiomas in the head and neck area using steroids.…”

Section: Discussionmentioning

confidence: 99%

Cavernous Hemangioma of the Scrotum Treated with Local Steroid: Case Report

Güneş¹,

Keleş²,

Çiloğlu³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…The efficacy of steroids in the treatment of IH was initially observed by Zarem and Edgerton, who noted that hemangiomas decreased in size when steroids were used to treat paediatric patients for thrombocytopenia (Zarem and Edgerton 1967). A number of studies have since been published on the efficacy of steroid therapy in the treatment of hemangiomas (Enjolras and Mulliken 1993;Martins 1970;Pandey et al, 2009).…”

Section: Steroid Therapymentioning

confidence: 99%

Hemangiomas - current therapeutic strategies

Mabeta

Pepper²

2011

Int. J. Dev. Biol.

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Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present with complications, and may thus require treatment. There are multiple therapeutic options available for patients with problematic or life threatening hemangiomas, some of which have serious side effects. Randomized clinical trials and evidencebased studies on the efficacy of these treatments is still lacking. The recognition that excessive angiogenesis underlies hemangiogenesis offers an opportunity for the development of safer therapeutic strategies that are based on the inhibition of angiogenesis. We review medical therapies currently employed in the management of hemangiomas and the role of angiogenesis inhibition in hemangioma therapy.

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Induced Resolution of Cavernous Hemangiomas Following Prednisolone Therapy

Cited by 41 publications

References 0 publications

Abordagem terapêutica dos hemangiomas cutâneos na infância

Abordagem terapêutica dos hemangiomas cutâneos na infância

Cavernous Hemangioma of the Scrotum Treated with Local Steroid: Case Report

Hemangiomas - current therapeutic strategies

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