Induced pluripotent stem cells to generate skin tissue models

Kashpur, Olga; Smith, Avi; Mukhamedshina, Nailia; Baskin, Jeremy M.; Shamis, Yulia; Hewitt, Kyle J.; Gerami‐Naini, Behzad; Garlick, Jonathan A.

doi:10.1016/b978-0-12-810545-0.00017-6

Cited by 2 publications

(2 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various skin replacements including xenografts, autografts, and allografts have been utilized to assist in the wound healing process, however, these kinds of skin substitutes are not ideal for skin regeneration due to the immune response of the body . Hence, significant research and development efforts in the field of tissue engineering have been made and have led to the creation of functional skin tissue substitutes . The design of three‐dimensional (3D) scaffolds with the biological characteristics and functions of the native extracellular matrix (ECM) is one of the most important challenges in tissue engineering …”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5] Hence, significant research and development efforts in the field of tissue engineering have been made and have led to the creation of functional skin tissue substitutes. [6][7][8] The design of threedimensional (3D) scaffolds with the biological characteristics and functions of the native extracellular matrix (ECM) is one of the most important challenges in tissue engineering. [9,10] To develop a clinical 3D construct, the performance of decellularized tissues as biological scaffolds were evaluated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Graphene functionalized decellularized scaffold promotes skin cell proliferation

et al. 2019

View full text Add to dashboard Cite

An increasing number of new strategies for skin tissue engineering have been developed with the potential to mimic the biological properties of native tissue with a high degree of complexity, flexibility, and reproducibility. In this study, decellularized tissue (DT) was prepared from the bovine heart by using chemical treatments. However, the mechanical properties of the DT constructs were poorer than the extra cellular matrix of the skin tissue. To overcome this challenge, hybrid scaffolds of DT and graphene oxide (GO) were developed and the effects of the GO concentration on the morphology, pore size, porosity, mechanical strength, and water uptake capacity of the samples were evaluated. Moreover, the biocompatibility of hybrid scaffolds was studied by Live/Dead staining. The results show that a hybrid scaffold incorporating 3 % graphene oxide improved the mechanical strength and cell viability by ~25 % in comparison to the DT scaffolds. Cell viability results confirmed that the porous scaffolds could support cell adhesion, proliferation, and cell activity for 7 days. This study provides new insight into and opportunities for using graphene‐based materials to develop biomimetic constructs for clinical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Graphene functionalized decellularized scaffold promotes skin cell proliferation

et al. 2019

View full text Add to dashboard Cite

show abstract

Role of Modern Technologies in Tissue Engineering

Ali

Malik

et al. 2020

Arch Neurosci

View full text Add to dashboard Cite

Nanotechnology is a rapidly developing field with numerous applications spread in different fields, especially medicine. It plays a role in tissue engineering, tissue regeneration, drug delivery, and regenerative medicine. The present brief review summarizes the role of nanotechnology in tissue engineering and tissue regeneration. The CRISPR/Cas9 system in tissue engineering is playing an important role, as CRISPR is a revolutionary genome-editing technology that is being used for tissue engineering where it emphasizes to address tissue architecture formation, immune response circumvention, cell differentiation, and disease model development. Moreover, the development and research expenses for tissue engineering and regenerative medicine are too high and there is a need for making these systems cost-effective. Thus, the advanced approach of applications of nanotechnology to regenerative medicine and CRISPR will definitely revolutionize the basis of treatment, prevention, and diagnosis of various diseases.

show abstract

Induced pluripotent stem cells to generate skin tissue models

Cited by 2 publications

References 103 publications

Graphene functionalized decellularized scaffold promotes skin cell proliferation

Graphene functionalized decellularized scaffold promotes skin cell proliferation

Role of Modern Technologies in Tissue Engineering

Contact Info

Product

Resources

About