Induced Oxidative Stress and Decreased Expression of Inducible Heat Shock Protein 70 (ihsp 70) in Patients with Colorectal Adenocarcinomas

Erata, Gül Özdemirler; Kanbagli, Öznur; Durlanık, Özgür; Bulut, Türker; Toker, Gülçin; Uysal, Müjdat

doi:10.1093/jjco/hyi022

Cited by 19 publications

(14 citation statements)

References 23 publications

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“…Observations similar to our findings have been reported in human colorectal cancer [29], lung cancer [30], colorectal adenocarcinomas [31], human malignant tumors of the kidney [32] and prostate cancer [33]. However, this does not agree with the results obtained on tissue MDA levels in OSCC, as studied by Balasenthil et al [34 ]and Saroja et al [35].…”

Section: Discussionsupporting

confidence: 69%

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Korde¹,

Basak

Chaudhary³

et al. 2011

Oncology

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Objective: Interaction between reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a crucial determinant in the etiology of oral squamous cell carcinoma (OSCC), and antioxidants protect against cellular and molecular damage caused by these. This study aims to evaluate ROS and RNS, together with the total antioxidant capacity (TAC), in serum and tissues of OSCC patients. Method: Total nitric oxide (TNO), malondialdehyde (MDA), and TAC were evaluated using a UV visible spectrophotometer in the serum of 30 controls, 30 precancer and 30 OSCC patients and in tissues of 10 controls and 30 OSCC patients. Results: MDA and TNO were significantly elevated with concomitant depletion of TAC in serum and tissues of OSCC patients when compared to controls. A significant positive correlation (p = 0.01), at different levels between TNO and MDA in OSCC patients, was found, which increased with the grade of OSCC. Conclusion: An increase in the levels of TNO, NO-mediated lipid peroxidation, resulting in an increase in MDA levels, the positive TNO-MDA correlation with a deranged antioxidant defense system as demonstrated by significantly low levels of TAC; when all these facts are taken together, we can conjecture that oxidative DNA damage, a vital phenomenon for carcinogenesis, occurs due to the interplay of ROS, RNS and TAC.

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Section: Discussionsupporting

confidence: 69%

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Korde¹,

Basak

Chaudhary³

et al. 2011

Oncology

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“…Results showed that DSS administration led to a remarkable elevation and reduction in MDA content and CAT activity, respectively. 56,57 Accordingly, as our result showed that crocin may play an important role in CRC prevention and also therapy by increasing antioxidant levels while decreasing oxidants. Interestingly, crocin and 5-FU combined treatment of azoxymethane-induced colon cancer rats notably recovered the increased levels of MDA and decreased activity of CAT, as well as the decline in total thiol concentration.…”

Section: Discussionmentioning

confidence: 58%

Crocin synergistically enhances the antiproliferative activity of 5‐flurouracil through Wnt/PI3K pathway in a mouse model of colitis‐associated colorectal cancer

Amerizadeh

Rezaei

Rahmani

et al. 2018

J of Cellular Biochemistry

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Colorectal cancer (CRC) is the third most common cause of cancer-related death, and hence there is a need for the identification of novel-agents to improve the efficacy of existing therapies. There is growing evidence for the antitumor activity of crocin, although its activity and molecular mechanisms in CRC remains to be elucidated. Here we explored the therapeutic application of crocin or its combination with 5-flurouracil in a mouse model of colitis-associated colon cancer. The antiproliferative activity of crocin was assessed in two-dimensional and three-dimensional cell-culture models. The migratory behaviors were determined, while the expression levels of several genes were assessed by quantitative reverse transcriptase polymerase chain reaction/Western blot analysis. We examined the anti-inflammatory properties of crocin by pathological evaluation and disease-activity index as well as oxidative or antioxidant markers: malondialdehyde (MDA) and total-thiols (T-SH) levels and superoxide dismutase (SOD) and catalase (CAT) activity. Crocin suppressed cell-growth and the invasive behavior of CRC cells through modulation of the Wnt-pathway and E-cadherin. Moreover, administration of crocin alone, or in combination with 5-FU dramatically reduced the tumor number and tumor size in both distal/mid-colon followed by reduction in disease-activity index. Crocin also suppressed the colonic inflammation induced by dextran-sulfate-sodium and notably recovered the increased levels of MDA, decreased thiol levels and activity of CAT levels. Crocin was able to ameliorate the severe inflammation with mucosal ulcers and high-grade dysplastic crypts as detected by inflammation score, crypt loss, pathological changes and histology scores. We demonstrated an antitumor activity of crocin in CRC and its potential role in improvement of inflammation with mucosal ulcers and high-grade dysplastic crypts, supporting the desireability of further investigations on the therapeutic potential of this approach in CRC.

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“…An imbalance between antioxidants and ROS results in oxidative stress, leading to cellular damage (Rezaie et al, 2007) and subsequently cell death or cancer. Colorectal cancer is a heterogeneous neoplasm consisting of cancer cells with various proliferation rates and the potential to metastasise (Ozdemirler Erata et al, 2005). Genetic alterations caused by cellular overproduction of ROS are required for neoplastic progression www.intechopen.com Soderlund et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Genetic alterations caused by cellular overproduction of ROS are required for neoplastic progression www.intechopen.com Soderlund et al, 2010). Such changes are based on DNA damage triggered by endogenous but also by environmental and lifestyle genotoxins (Bartsch et al, 2002;Ozdemirler Erata et al, 2005). As the onset of cancer is a prolonged multi-stage process where successive mutations are accumulated, continuous erosion of the genome and defects in repair contribute to this process (Hoeijmakers, 2001;Jiricny and Marra, 2003).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Flavonoids in Soybean Products in Lymphocytes from IBD and Colon Cancer Patients After Treatment with Food Mutagens and Hydrogen Peroxide

Najafzadeh¹,

Kurzawa-Zegota²,

Baumgartner³

et al. 2011

Soybean and Health

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Induced Oxidative Stress and Decreased Expression of Inducible Heat Shock Protein 70 (ihsp 70) in Patients with Colorectal Adenocarcinomas

Cited by 19 publications

References 23 publications

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Enhanced Nitrosative and Oxidative Stress with Decreased Total Antioxidant Capacity in Patients with Oral Precancer and Oral Squamous Cell Carcinoma

Crocin synergistically enhances the antiproliferative activity of 5‐flurouracil through Wnt/PI3K pathway in a mouse model of colitis‐associated colorectal cancer

The Effect of Flavonoids in Soybean Products in Lymphocytes from IBD and Colon Cancer Patients After Treatment with Food Mutagens and Hydrogen Peroxide

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