Induced malabsorbtion in chickens by experimental administration of ochratoxin A

Solcan, Carmen; Floriștean, V.; Pavel, Geta; Solcan, G.

doi:10.1016/j.copbio.2013.05.321

Cited by 3 publications

(4 citation statements)

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“…Three studies identified in the literature search were not further considered due to weaknesses in reporting (Rao et al, 2018;Solcan et al, 2013b) and in design (Hameed et al, 2012). In particular, in Rao et al (2018), controversial description of experimental groups was identified, no statistics, no data on mortality; in Solcan et al (2013b) no statistics are reported, no data on zootechnical performance, mortality or symptoms of toxicity were provided; in Hameed et al (2012), no replicates were used and unclear data on the number of euthanised animals was reported. Adverse effects were described in growing chickens in 17 publications, in hens in four, in turkeys in four and in ducks in two studies.…”

Section: Poultrymentioning

confidence: 99%

“…A total of 37 studies was reviewed. Three studies identified in the literature search were not further considered due to weaknesses in reporting (Rao et al., 2018 ; Solcan et al., 2013b ) and in design (Hameed et al., 2012 ). In particular, in Rao et al.…”

Section: Assessmentmentioning

confidence: 99%

“…(2018), controversial description of experimental groups was identified, no statistics, no data on mortality; in Solcan et al. ( 2013b ) no statistics are reported, no data on zootechnical performance, mortality or symptoms of toxicity were provided; in Hameed et al. ( 2012 ), no replicates were used and unclear data on the number of euthanised animals was reported.…”

Section: Assessmentmentioning

confidence: 99%

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Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Schrenk,

Bignami,

Bodin

et al. 2023

EFS2

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In 2004, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks to animal health and transfer from feed to food of animal origin related to the presence of ochratoxin A (OTA) in feed. The European Commission requested EFSA to assess newly available scientific information and to update the 2004 Scientific Opinion. OTA is produced by several fungi of the genera Aspergillus and Penicillium. In most animal species it is rapidly and extensively absorbed in the gastro-intestinal tract, binds strongly to plasma albumins and is mainly detoxified to ochratoxin alpha (OTalpha) by ruminal microbiota. In pigs, OTA has been found mainly in liver and kidney. Transfer of OTA from feed to milk in ruminants and donkeys as well as to eggs from poultry is confirmed but low. Overall, OTA impairs function and structure of kidneys and liver, causes immunosuppression and affects the zootechnical performance (e.g. body weight gain, feed/gain ratio, etc.), with monogastric species being more susceptible than ruminants because of limited detoxification to OTalpha. The CONTAM Panel considered as reference point (RP) for adverse animal health effects: for pigs and rabbits 0.01 mg OTA/kg feed, for chickens for fattening and hens 0.03 mg OTA/kg feed. A total of 9,184 analytical results on OTA in feed, expressed in dry matter, were available. Dietary exposure was assessed using different scenarios based on either model diets or compound feed (complete feed or complementary feed plus forage). Risk characterisation was made for the animals for which an RP could be identified. The CONTAM Panel considers that the risk related to OTA in feed for adverse health effects for pigs, chickens for fattening, hens and rabbits is low.

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Section: Poultrymentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

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Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Schrenk,

Bignami,

Bodin

et al. 2023

EFS2

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“…Ochratoxins are a group of pentaketide mycotoxins found in fruit that are produced mainly by Aspergillus and Penicillium species [ 44 , 45 ]. The most important and most toxic ochratoxin found naturally in foods is ochratoxin A (OTA), which shows hepatotoxicity, teratogenicity, carcinogenicity, cytotoxicity, neurotoxicity, and immunosuppressive properties [ 46 , 47 , 48 , 49 , 50 , 51 ]. Two other forms of ochratoxin—B and C—are less toxic and less common [ 52 , 53 ].…”

Section: Mycotoxins Commonly Found In Fruitmentioning

confidence: 99%

Does the Host Contribute to Modulation of Mycotoxin Production by Fruit Pathogens?

Kumar

Barad

Sionov

et al. 2017

Toxins

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Storage of freshly harvested fruit is a key factor in modulating their supply for several months after harvest; however, their quality can be reduced by pathogen attack. Fruit pathogens may infect their host through damaged surfaces, such as mechanical injuries occurring during growing, harvesting, and packing, leading to increased colonization as the fruit ripens. Of particular concern are fungal pathogens that not only macerate the host tissue but also secrete significant amounts of mycotoxins. Many studies have described the importance of physiological factors, including stage of fruit development, biochemical factors (ripening, C and N content), and environmental factors (humidity, temperature, water deficit) on the occurrence of mycotoxins. However, those factors usually show a correlative effect on fungal growth and mycotoxin accumulation. Recent reports have suggested that host factors can induce fungal metabolism, leading to the synthesis and accumulation of mycotoxins. This review describes the new vision of host-factor impact on the regulation of mycotoxin biosynthetic gene clusters underlying the complex regulation of mycotoxin accumulation in ripening fruit.

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Effects of temperature and incubation time on growth and ochratoxin A biosynthesis by Aspergillus carbonarius and Aspergillus ochraceus in grain-based media

Souza¹,

Pereira²,

Passamani³

et al. 2016

Afr. J. Microbiol. Res.

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Ochratoxin A (OTA) has been frequently found as a food contaminant, and it is considered one of the mycotoxins most harmful to human health. In this context, this study was performed aiming to evaluate mycelial growth and ochratoxin A production from three isolates of Aspergillus carbonarius and Aspergillus ochraceus. The isolates were inoculated on culture media coffee, wheat and maize as well as YES medium and cultivated at 15 and 25°C. Measurement of colony diameters was performed every 48 h for growth description. OTA quantification was made with high-performance liquid chromatography (HPLC) three times (5 th , 15 th and 25 th day). All the isolates presented higher growth rate in YES medium at 25°C; however, growth in every culture media at both tested temperatures was observed. The maize-based medium showed the lowest growth rate. YES medium induced the most OTA production. In grain-based culture media, A. ochraceus isolates produced lower quantities of OTA, reaching a maximum of 9.95 µg/g. However, A. carbonarius isolates produced much higher quantities, showing the A. carbonarius CCDCA10608 isolate, which produced 29.83 µg/g at 15°C in YES medium and 13.06 in wheat-based medium at 15°C. Therefore, among the tested conditions, those more and less favorable to OTA production were recognized.

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Induced malabsorbtion in chickens by experimental administration of ochratoxin A

Cited by 3 publications

References 0 publications

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Does the Host Contribute to Modulation of Mycotoxin Production by Fruit Pathogens?

Effects of temperature and incubation time on growth and ochratoxin A biosynthesis by Aspergillus carbonarius and Aspergillus ochraceus in grain-based media

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