Induced Hypersensitivity to Combinations of Serotonin and Histamine in a Strain of Mice Ordinarily Highly Resistant to Histamine Sensitization

Sensitivity to Intravenous Injections of Histamine and Serotonin in Inbred Mouse Strains

“…As shown in table II, their hemo concentration rates were intermediate be tween the parental strains. A significant potentiation of the toxicity of histamine and serotonin for mice is ob served when these substances are used in mixture [1,9]. No quantitative estimation of the magnitude of serotonin release occurring during mouse anaphylaxis (e.g.…”

“…On the other hand, there is very solid evidence in dicating that both histamine and serotonin are released from mouse tissues during ana phylaxis [24], and that pretreatment of mice with drugs which antagonize actions of both histamine and serotonin is very effective in abrogating anaphylactic symptoms in mice [7,25]. We have previously demonstrated that injections of histamine-serotonin mix tures are significantly more effective in in ducing anaphylactic-like shock syndromes in the mouse [1,9]. In the present experi ments, the use of histamine-serotonin mix tures was also substantially more effective than histamine or serotonin alone for the characterization of differences in suscepti bility of different mouse strains to anaphy lactic-like shock.…”

“…Injections of relatively high doses of ei ther histamine or serotonin alone in normal mice of different strains, with rare excep tions, fail to induce severe or lethal symp toms similar to those observed in severe an aphylactic shock; this may be achieved, however, by the injection of significantly lower doses of mixtures of histamine and serotonin [1,9].…”

Action of the Histamine Sensitizing Factor from <i>Bordetella pertussis </i>on Inbred and Random Bred Strains of Mice

“…The normal Rocky Mountain Laboratory (RML) strain of mouse was quite resistant to the lethal effect of serotonin and histamine alone or in combinations [8]. However, when these mice were adrenalectomized or treated with HSF or the /?-adrenergic blocking agent, propranolol, they became markedly sensitive to combinations of sero tonin and histamine, while still retaining their resistance to either of the drugs given singly.…”

Effects of <i>Bordetella pertussis </i>on the Sensitivity of Inbred Mice to Vasoactive Amines

“…Anaphylactic-like hypovolemic shock syndromes may be induced in mice by injec tions of histamine, serotonin, or histamineserotonin mixtures [1,2,9,10]. Inbred strains of mice vary widely in their sensitivi ty to these treatments [2,10,16,20,22].…”