Action of the Histamine Sensitizing Factor from &lt;i&gt;Bordetella pertussis &lt;/i&gt;on Inbred and Random Bred Strains of Mice

Bergman, R. K.; Muñoz, J.

doi:10.1159/000230127

Cited by 23 publications

(20 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In view of these findings, and because /5-adrenergic blocking agents are known to enhance the sensitivity of guinea pigs to histamine [28,29], we decided to reinvestigate the effect of B. pertussis on the sensitivity of guinea pigs to a histamine challenge. Our results indicate that it is unlike ly that pertussis vaccine can induce any marked degree of histamine-sen sitization in guinea pigs, comparable with that seen in mice and rats [5,22]. This is evident from the barely significant and by no means impres sive mortality results in pertussis-vaccinated guinea pigs challenged with histamine (table IV), and the similarity in respiratory responses between pertussis-treated and control guinea pigs receiving histamine ( fig.…”

Section: Discussionsupporting

confidence: 62%

<i>Bordetella pertussis</i> as a Beta-Adrenergic Blocking Agent

Pieroni¹,

Bundeally²,

Amdur³

et al. 1971

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Further evidence is presented indicating that the sensitizing effects of Bordetella pertussis may be mediated by blockade of β-adrenergic receptors of the autonomic nervous system. Both the extracted histamine-sensitizing factor (HSF) of B. pertussis and the β-adrenergic blocking agent, propranolol, were found capable of enhancing the sensitivity of mice to experimental immune hemolytic anemia, hypothermic stress, and bacterial endotoxin. Although pertussis-vaccinated guinea pigs exhibited a slightly higher mortality following histamine challenge, no differences were detected in the respiratory responses (pulmonary compliance and resistance) of pertussis-inoculated and control guinea pigs following histamine. These results indicate that the action of B. pertussis is more selective among species than are the β-adrenergic blocking agents such as propranolol.

show abstract

Section: Discussionsupporting

confidence: 62%

<i>Bordetella pertussis</i> as a Beta-Adrenergic Blocking Agent

Pieroni¹,

Bundeally²,

Amdur³

et al. 1971

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…In fact, SJL, SWR, and CFW serve as the three susceptible prototype strains, while C3H/HeJ and CBA/J are their resistant counterparts (9-11, 13, 14, 25). Conflicting results have been reported for the majority of other mouse strains (9)(10)(11)25). Factors that contribute to the varying results observed among different laboratories include the route of injection of both PTX and histamine challenge, the preparation of pertussis vaccine or PTX or both, the environmental status of the animals, infectious agents, and the age of the mice (13,14).…”

mentioning

confidence: 99%

“…Factors that contribute to the varying results observed among different laboratories include the route of injection of both PTX and histamine challenge, the preparation of pertussis vaccine or PTX or both, the environmental status of the animals, infectious agents, and the age of the mice (13,14). With regard to the latter, DBA/2J mice have been reported by Linthicum and Frelinger (11) and Teuscher (12) to be resistant to histamine sensitization, whereas Bergman and Munoz (25) and Wardlaw (9) have found them to be susceptible. (9,10).…”

mentioning

confidence: 99%

Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.

Sudweeks

Todd

Blankenhorn

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Pertussis toxin (PTX) is the primary component responsible for eliciting the majority ofbiological activities associated with Bordetella pertussis, including the induction of several tissue-adjuvant models of organ-specific autoimmune disease. PTX, when administered in vivo, enhances vascular permeability, which is made manifest by a concomitant increase in sensitivity to a variety of agents and treatments affecting the vascular bed. One such agent is histamine, and the response to PTX, as measured by hypersensitivity following vasoactive amine challenge, is genetically controlled by the Bphs locus. Susceptibility to the induction of both experimental allergic encephalomyelitis (EAE) and experimental allergic orchitis (EAO) in mice is associated with, and in the latter case linked to, a susceptible allele at this locus. We report here the mapping of the Bphs locus to mouse chromosome 6, telomeric of Tcrb and centromeric of Prp (D6Nds8). This region also contains a number of loci of immunologic relevance including Igk, Ly-2, Ly-3, ll-5r, Ly-35, Ly-4, and Tnfr-2.

show abstract

“…The CFW mouse is a Swiss-Webster strain obtained from Corworth Farms, New City, N.Y. and has been bred in the Rocky Mountain Laboratory for the last 15 years. These mice respond to endotoxin and are highly susceptible to the histamine sensitizing action of pertussigen (2). The C57BL/IOScN mice are an inbred strain which is endotoxin unresponsive and is not susceptible to the histamine sensitizing action of pertussigen (2).…”

Section: B)mentioning

confidence: 99%

“…These mice respond to endotoxin and are highly susceptible to the histamine sensitizing action of pertussigen (2). The C57BL/IOScN mice are an inbred strain which is endotoxin unresponsive and is not susceptible to the histamine sensitizing action of pertussigen (2). It is unlikely that the difference in the action of DNT on the spleen between C57BL/IOScN and CFW mice was caused by contaminating endotoxin (10) because the heated DNT did not induce an increase in the spleens of both strains of mice.…”

Section: B)mentioning

confidence: 99%

Effect of Dermonecrotic Toxin of Bordetella pertussis on the Spleen of CFW and C57BL/10ScN Mice

Sekiya

Muñoz

Nakase

1982

Microbiology and Immunology

View full text Add to dashboard Cite

The dermonecrotic toxin (DNT), also called heat-labile toxin, was discovered by Bordet and Gengou (3) in extracts of Bordetella pertussis cells. The toxin had a marked necrotic effect on the skin of rabbits and guinea pigs and a degenerative action on the spleens of mice (5,7,12). The toxicity was inactivated at 56 C for 10 min (4,6,8). In this note we describe a pronounced difference in the response of spleens from CFW (random bred) and C57BL/IOScN (inbred) mice, raised in the animal production unit at the Rocky Mountain Laboratory, to the effects of this toxin. To our knowledge, differences among strains of mice in their response to purified DNT have not been recorded in the literature.DNT was prepared by a modification of Iida and Okonogi's method (5) and partly Nakase's method (9) from a Phase I Maeno strain of B. pertussis (agglutinogen type 1.2.3.4) grown in a modified synthetic medium of Stainer and Scholte (composition given in Ref. 1). The medium (500 ml per 4-liter Erlenmeyer flask) was inoculated with 2 ml of a cell suspension containing 25 X 10 9 cells per ml. The inoculum was prepared from 24-hr-old Bordet-Gengou agar cultures (composition given in Ref. 7). The inoculated flasks were incubated for 5 days at 35 C under stationary conditions; the cells were then collected by centrifugation (3,000 xg for 1 hr) and resuspended in cold sterile water to a concentration of 10 12 cells per ml. These cells were sonically disrupted (kept cold with iced water) in a Biosonik III apparatus (Bronwill Scientific, Rochester, N.Y.) at 20 kHz for 5 min. The disrupted cells were centrifuged at 27,000 xg for 20 min to remove the cell debris, and the supernatant containing the DNT was collected by decantation. All steps were carried out at 2 to 10 C. About 6 ml of the clear solution of DNT was passed through a DEAE-Sephacel column (2.5 X 60 cm) equilibrated in 0.01 M phosphate buffer (pH 8.0) containing 20 mM sucrose. The column was successively eluted with (i) 800 ml of0.01 Mphosphate buffer, pH 8; (ii) 450 ml of 0.05 Mbuffer, pH 7.2; and (iii) 800 ml of 0.2 M buffer, pH 7.0. All the buffers contained 20 mx sucrose as a stabilizer of the toxin. The toxin, assayed by its dermonecrotic action in the

show abstract

Action of the Histamine Sensitizing Factor from <i>Bordetella pertussis </i>on Inbred and Random Bred Strains of Mice

Cited by 23 publications

References 8 publications

<i>Bordetella pertussis</i> as a Beta-Adrenergic Blocking Agent

<i>Bordetella pertussis</i> as a Beta-Adrenergic Blocking Agent

Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.

Effect of Dermonecrotic Toxin of Bordetella pertussis on the Spleen of CFW and C57BL/10ScN Mice

Contact Info

Product

Resources

About