Induced endogenous autotoxicity in Camptotheca

Li, Shiyou; Wang, Ping; Wei, Yuan

doi:10.2741/e179

Cited by 9 publications

(27 citation statements)

References 47 publications

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“…Surprisingly, however, we found that decapitation in mature Camptotheca induced abnormal morphogenesis in planta: dramatic morphological deviations from normal development [117]. After decapitation in March, almost all newly spread leaves in the mature trees are non-entire (serrate and lobed).…”

Section: Induced Biosynthesis Of Target Compounds By Pruningmentioning

confidence: 69%

“…The abnormal morphogenesis appears correlatively with the elevated CPT contents following decapitation pruning [117]. Plants resume their normal morphogenesis when CPT is reduced to natural levels after stress discontinuation.…”

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 94%

“…bidentate, bifid, tridentate, and trifid) (Fig. 6) [117]. Nonserrate abnormal leaves during new growth gradually disappeared until August while the serrate form among new leaves gradually decreased to 41.5% in October.…”

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 96%

“…B. Changes of CPT contents in young leaves of the 6-year-old mature trees with pruning in March in comparison with untreated trees [117]. species, 35 alkaloids and triterpenoid glycosides have been isolated, including six new triterpenoid glycosides (Fig.…”

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 99%

“…6) [117]. Fast-growing Camptotheca plants can avoid poison by its endogenous camptothecin (DNA topoisomerase I inhibitor) at more than 10 times higher than the fatal concentration of exogenous application to the plant.…”

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 99%

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Trichome Management to Enhance Camptothecins in Camptotheca Decaisne

Li¹,

Zhang²,

Wang³

et al. 2014

TOPHARMCJ

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Inducible chemical defenses of plants have received much attention in the last three decades, and these defenses often involve trichomes. It is known that some plant secondary metabolites may accumulate in trichomes which can protect plants from damage by herbivores. However, studies on plant trichomes are largely limited to some major vegetable or cash crops and model species with large glandular trichomes (e.g., Nictotiana and Arabidopsis). In fact, the existing studies on the effect of damage (pruning or defoliation) on trichome density or chemical production in plants are partial and even contradictory. Management strategies to maximize chemical induction in medicinal plants or pharmaceutical crops have not been developed well. Our experiments showed that camptothecins (CPTs) are primarily accumulated in glandular trichomes in Camptotheca. We found that pruning, particularly decapitation pruning (T-pruning) can effectively induce contents and derivatization of CPTs in Camptotheca, and the leveled CPTs caused induced endogenous autotoxicity (abnormal morphogenesis) in the plants. Auxin reduction is a trigging factor for such induced biosynthesis and endogenous autotoxicity. Because trichomes are visible to the naked eye and can be much more easily targeted and measured than CPTs, the term "Trichome Management" is used for strategy development to induce CPTs in Camptotheca.

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Section: Induced Biosynthesis Of Target Compounds By Pruningmentioning

confidence: 69%

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 94%

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 96%

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 99%

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 99%

See 3 more Smart Citations