Induced apical closure of immature pulpless teeth in monkeys

Endodontic Clinical Management of a Dens Invaginatus Case by Using a Unique Treatment Approach: A Case Report

“…Periapical tissues contain pluripotential cells that can survive inflamation and necrosis as well as differentiate into cells that can lay down hard dental tissue (26). One animal study demonstrated the tissue formed at the root end is a cellular cementoid-type material (27). The tissue formed within the root canal space is speculated to be composed of osteodentin (28), bone or bone-like tissues, periodontal ligament, and cementum (14).…”

An Animal Model to Study Regenerative Endodontics

“…Several investigators experimentally infected the root canals of immature teeth in monkeys and produced apical periodontitis in these animals (21)(22)(23)(24)(25)(26). After debridement, disinfection, production of a blood clot, and sealing of the root canals, the authors examined the extent of tissue growth and the types of tissues present in the root canals.…”

A Clinical and Histological Report of a Tooth with an Open Apex Treated with Regenerative Endodontics Using Platelet-rich Plasma

“…T he potential for dental tissue regeneration and continued root development of replanted teeth has been well documented in the dental literature; however, the presence of infection has been shown to interfere with this process (1)(2)(3). Traditionally, it has been thought that successful regeneration cannot be an expected outcome after a tooth has become infected.…”

“…Although the radiographic appearance of apical closure and canal wall thickening can give the impression that a normal, functional pulp has regenerated, there is no histologic evidence to support these findings. There are several animal studies (3,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) examining the nature of tissues present in the root canals of teeth treated with regeneration procedures (Table 2). Connective tissue, cementum, and bone have been reported in these teeth.…”