Induced abortion and breast cancer

The adipokine resistin is linked with obesity, inflammation and various cancers, including breast cancer. This study sought to determine whether certain polymorphisms in the gene encoding resistin, RETN, increase the risk of breast cancer susceptibility. We analyzed levels of resistin expression in breast cancer tissue and samples from The Cancer Genome Atlas database. We also examined associations between four RETN single nucleotide polymorphisms (SNPs; rs3745367, rs7408174, rs1862513 and rs3219175) and breast cancer susceptibility in 515 patients with breast cancer and 541 healthy women without cancer. Compared with wild-type (GG) carriers, those carrying the AG genotype of the RETN SNP rs3219175 and those carrying at least one A allele in the SNP rs3219175 had a higher chance of developing breast cancer (adjusted odds ratio, AOR: 1.295, 95% confidence intervals, CI: 1.065-1.575 and 2.202, 1.701-2.243, respectively). When clinical aspects and the RETN SNP rs7408174 were examined in the breast cancer cohort, the CT genotype was linked to late-stage disease, while women with luminal A disease and at least one C allele were likely to progress to stage III/IV disease and to develop highly pathological grade III disease. Moreover, resistin-positive individuals were at greater risk than resistin-negative individuals for developing pathological grade III disease (OR: 5.020; 95% CI: 1.380-18.259). This study details risk associations between resistin and RETN SNPs in breast cancer susceptibility in Chinese Han women.

show abstract

“…International Publisher as family history [2] and gynecological diseases such as adenomyosis and polycystic ovarian syndrome [3,4].…”

Section: Ivyspringmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A Chinese study showed that abortion does not increase the risk of breast cancer, and the latest meta-analysis had not found a relationship between abortion and breast cancer risk [12]. A study by Ilic et al [28] suggested that even short pregnancies ending in abortion add to the protection against breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…In China, the incidence of breast cancer has consistently ranked first among women in cancer incidence. Studies have shown that age at menarche [2], age at first pregnancy [3], feeding mode [4], family history of breast cancer [5], age [6], BMI [7], alcohol consumption [8], smoking [9], history of proliferative benign breast disease [10], oral contraceptives [11], abortion [12], breast density [13,14], history of hyperthyroidism [15], etc., even night shift work [16], exercise [17], diet [18] was related to the onset of breast cancer, regrettably no consensus has been reached [19,20]. In short, the breast volume has not been included in the traditional breast cancer risk list.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Formulaic Breast Volume And Risk Of Breast Cancer Based On Linear Measurement

Zhou²,

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Whether breast volume is a risk factor for breast cancer has been controversial. This study aimed to evaluate whether or not the significant association between breast volume and risk of breast cancer based on linear measurement by applying Propensity Score Matching (PSM) was present.Methods: The study was designed as a hospital-based case-control study. Between March 2018 and May 2019, 208 cases and 340 controls were retrospectively reviewed. Information on menarche, smoking, feeding mode, oral contraceptives, reproductive history and family history was obtained through a structured questionnaire. Calculate breast volume using formula based on the linear measurement of breast parameters. Cox regression and PSM were used to estimate odds ratios and 95% confidence intervals for breast cancer by risk factors adjusted for potential confounders.Results: There was a significant difference in breast volume between two groups before Propensity Score Matching(P=0.014) : P=0.009, OR=1.002, 95% CI: 1.000~1.003). Binary logistic regression showed that the risk of breast cancer was slightly higher in the case group with larger breast volume than in the control group P=0.009, OR=1.002 95%CI 1.000 1.003). However, there was no significant statistical difference between two groups in independent sample Mann-Whitney U test (P=0.438) and in conditional logistic regression (P=0.446).Conclusions: After PSM for the potential confounders factors, the breast volume of cases did not differ from that of controls. The risk of breast cancer may not related to breast volume in Chinese women.

show abstract

“…[25] reported a higher risk of BC in parous women with preterm delivery below 32 weeks compared with women with term delivery. Yongchun Deng et al [36] in a meta-analysis study revealed that in parous women, induced abortion can increase the BC risk, but it was not significant in the nulliparous women.…”

Section: Discussionmentioning

confidence: 99%

Preterm Birth and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Razavi¹,

Sepidarkish²,

Maleki‐Hajiagha³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The characteristics of pregnancy, such as gestational age are related to the level of maternal hormones, which levels of these hormones can be associated with breast cancer (BC) risk. Therefore, the aim of this study was to determine the relationship between the preterm birth (PB) and BC risk in women in a systematic review and meta-analysis.Methods: In this systematic review and meta-analysis, published studies were located back to the earliest available publication date (1983), using the Medline/PubMed, Embase, Scopus and Web of Science (Clarivate analytics) bibliographic databases. Eligibility, methodological quality, and data extraction were done by two independent reviewers, and finally, to calculate the pooled estimates, Meta-analysis was performed.Results: Thirteen studies including a total of 2,845,553 women were included in this meta-analysis. Pooled results suggested that PB could increase the risk of BC (RR= 1.03, 95% CI: 1.00, 1.07; I2= 62.5%). Risk was significantly increased in women with a PB at >37 gestational weeks (RR = 1.03, 95% CI: 1.01, 1.06) and 26-31 gestational weeks (RR = 1.03, 95% CI: 1.01, 1.06) compared to those with 40-41 gestational weeks. A significant increment in the risk of BC in uniparous women with a PB (RR = 1.05, 95% CI = 1.01, 1.08) and women with >45 years (RR = 1.12, 95% CI = 1.01, 1.24) was observed. Conclusions: The results of this study supported the higher risk of BC in all woman with PB, primiparous women and women with >45 years. Therefore, more care and screening for early detection of the disease is recommended in these women.

show abstract

Induced abortion and breast cancer

Abstract: Supplemental Digital Content is available in the text

Cited by 22 publications

References 42 publications

Impacts of RETN genetic polymorphism on breast cancer development

Impacts of RETN genetic polymorphism on breast cancer development

Relationship Between Formulaic Breast Volume And Risk Of Breast Cancer Based On Linear Measurement

Preterm Birth and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About