Indonesian propolis: chemical composition, biological activity and botanical origin

Abstract

From a biologically active extract of Indonesian propolis from East Java, 11 compounds were isolated and identified: four alk(en)ylresorcinols (obtained as an inseparable mixture) (1-4) were isolated for the first time from propolis, along with four prenylflavanones (6-9) and three cycloartane-type triterpenes (5, 10 and 11). The structures of the components were elucidated based on their spectral properties. All prenylflavanones demonstrated significant radical scavenging activity against diphenylpicrylhydrazyl radicals, and compound 6 showed significant antibacterial activity against Staphylococcus aureus. For the first time Macaranga tanarius L. and Mangifera indica L. are shown as plant sources of Indonesian propolis.

Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line

“…Considering only Pacific propolis, Su et al [19] reported the presence of propolin in Taiwanese propolis and ten phenylpropanoic acid esters were found in Korean propolis [20]. In addition, 11 compounds were reported from Indonesian propolis but, interestingly, not cardol [21]. In this research, we reported how cardol, also a major compound in the Indonesian propolis from at least T. incisa , could induce apoptosis in SW620 cells.…”

Cytotoxic and cancer chemopreventive properties of prenylated stilbenoids from Macaranga siamensis

“…A coupling constant about 12 Hz for H-a and H-b of 3, 4, 5, 8, 9, 15, and 16 suggested the presence of a cis-stilbene core instead of a trans-stilbene. 22 Therefore, compounds 3,4,5,8,9,15, and 16 were elucidated as shown in Fig. 1 and named as macasiamenenes C, D, E, H, I, O, and P, respectively.…”

“…1 Some species has been used as a traditional Thai medicine for antipyretic, antitussive and antiinflammatory treatment: 2 phytochemical studies of this genus have revealed a number of phenolic compounds, particularly stilbenoids 3 and flavonoids. 4 Biological investigations of the compounds derived from the Macaranga genus have shown that some compounds exhibit cytotoxic, 3,4 antibacterial, 5 antifungal, 6 a-glucosidase, 7 quinone reductase inhibitory, 8 anti-inflammatory 4,9 or DPPH radical scavenging activities. 4,10 Macaranga siamensis S.J.…”

Propolis to Curb Lifestyle Related Disorders: An Overview

“…In Mongolia, the sole source of propolis appeared to be P. suaveolens, the only poplar growing in this country. In Albania, propolis is collected partially from P. nigra buds, but there are other unidentified sources [17,18]. Typical source of European propolis are poplar tree buds [15] whereas poplar trees can't grow in tropical and subtropical regions.…”