Cytotoxic and cancer chemopreventive properties of prenylated stilbenoids from Macaranga siamensis

N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer

“… 21 Evidence is emerging to indicate that prenylation of other molecules from natural sources could offer a new spectrum of antitumor agents. 22 – 24 Such reports, together with the presence of tryptophan residues in the pentamer sequence, provided the vision to explore N-tert -prenylation on the indole ring as a possible means to design improved SPG-related analogues for SCLC treatment. The design led to penta-peptide 2 ( Fig.…”

Impact of Environmental Factors on Stilbene Biosynthesis

“…Prenylated stilbenoids have been isolated from a restricted number of stilbene-producing plants including Macaranga spp. (Euphorbiaceae) [135,136], Glycyrrhiza spp. [137][138][139][140], peanut [141][142][143][144][145][146], and mulberry [147].…”

“…In accordance with their role as phytoalexins, peanut prenylated stilbenoids have been shown to accumulate upon challenge with microorganisms [142][143][144][145]149] and to possess remarkable antifungal activity [150][151][152]. Several recent studies have shown interesting therapeutic potential for peanut prenylated stilbenoids [135,136,153,154]. Prenylated compounds generally exhibit greater bioavailability than their non-prenylated counterparts, due to the increase in lipophilicity linked to the prenyl groups.…”

Bioassay-guided isolation and structure elucidation of cytotoxic stilbenes and flavonols from the leaves of Macaranga barteri

“…These plants are native to South-East Asia, West Africa and the South Pacific region [1]. Plants in this genus are used in folklore medicine for the treatment of boils, cancer, cough, cuts, diarrhoea, hypertension, stomach-ache, swellings and wounds [2][3][4][5][6]. Only about 10% of the plants in this genus have been investigated for their phytochemical constituents and biological activities.…”