Indonesian Perspective on Biomaterials and Medical Devices

Mahyudin, Ferdiansyah; Sukaryo, Sulistioso Giat; Siswomihardjo, Widowati; Hermawan, Hendra

doi:10.1007/978-3-319-14845-8_10

Cited by 11 publications

(11 citation statements)

References 3 publications

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“…Products incorporating acellular scaffolds including heart valves, small intestine submucosa and urinary bladder matrix have all been approved for human medical use [153]. However, as acellular scaffolds are typically allogenic or xenogeneic, there is potential for immune rejection for implanted scaffolds [154].…”

Section: Acellular Scaffoldsmentioning

confidence: 99%

Scaffolds for 3D in vitro culture of neural lineage cells

et al. 2017

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Neurodegenerative diseases, including dementia, Parkinson's and Alzheimer's diseases and motor neuron diseases, are a major societal challenge for aging populations. Understanding these conditions and developing therapies against them will require the development of new physical models of healthy and diseased neural tissue. Cellular models resembling neural tissue can be cultured in the laboratory with the help of 3D scaffolds - materials that allow the organization of neural cells into tissue-like structures. This review presents recent work on the development of different types of scaffolds for the 3D culture of neural lineage cells and the generation of functioning neural-like tissue. These in vitro culture systems are enabling the development of new approaches for modelling and tackling diseases of the brain and CNS.

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Section: Acellular Scaffoldsmentioning

confidence: 99%

Scaffolds for 3D in vitro culture of neural lineage cells

et al. 2017

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“…The combination of strength and controlled degradation rate during the healing process and safety for the human body are the most important requirements of implant materials. Almost 70% of implant materials are made of metals [3]. In particular, magnesium (Mg) and Iron (Fe) exhibit many uses in orthopedics and cardiovascular [4] applications [1,5].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, magnesium (Mg) and Iron (Fe) exhibit many uses in orthopedics and cardiovascular [4] applications [1,5]. Between them, Mg is considered superior to other metals [1,2,6,7]; it is the lightest metal (ρ 1.74-2.0 g cm −3 ), and it demonstrates the following: a modulus of elasticity similar to cortical and cancellous bones (41-45 GPa); a strength-to-weight ratio greater than those of polymers; and a high limit of toxicity in the body, 700 mg/day [3,5], compared to 10-20 mg/day of Fe. Mg also functions as an enzyme activator and protein regulator.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, Mg demonstrates several disadvantages, including a high degradation rate of 8 mm year [3] and low strength and ductility (yield strength=30 MPa, ultimate tensile strength=100 MPa, ε=7%). Moreover, there have been cases where hydrogen gas bubbles appeared under the skin of the patient after a period of time [6].…”

Section: Introductionmentioning

confidence: 99%

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Microstructure and microhardness of carbonate apatite particle-reinforced Mg composite consolidated by warm compaction for biodegradable implant application

Setyadi

Marsetio

Kamal³

et al. 2020

Mater. Res. Express

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Magnesium-based composites with carbonate apatite reinforcement are attractive biodegradable implant materials. In this study, we observed the effect of carbonate apatite content (5, 10, and 15% wt.) and milling time (3, 5, and 7 h) on the microstructure and microhardness of magnesiumcarbonate apatite composites fabricated by powder metallurgy. The consolidation process involved warm compaction without sintering. Characterization was achieved through density testing, x-ray diffraction (XRD), optical microscopy, SEM-energy dispersive x-ray spectroscopy (EDS), and microhardness testing. The powder milling time affects the distribution of apatite carbonate; adding carbonate apatite can increase the hardness of magnesium-based composites. In the XRD spectrum, we identify the dominant magnesium peak but not the magnesium oxide peak. Carbonate apatite powder is distributed at the grain boundaries. The hardness range is 40.26-44.82 Hv or increase by 8.21%-20.23% compared to the hardness of consolidated pure magnesium. The relative density is around 95.92%-98.71%, whereas the relative density of pure magnesium is 99.58%. The obtained optimal conditions for fabricating magnesium composites are the following: content of 10 wt% carbonate apatite (milled for 5 h) with a hardness of 43.58 Hv.

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“…Biocompatibility of materials can be measured in vivo by observing the inflammatory and immunogenic responses to tissue. [ 15 16 ]…”

Section: Introductionmentioning

confidence: 99%

Inflammatory and immunogenic response of the tissue after application of freeze-dried hydroxyapatite gypsum puger scaffold compared to freeze-dried hydroxyapatite bovine scaffold

et al. 2020

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Background: Inflammation is a mechanism or reaction of the natural immune system to defend from external hazards. All foreign objects that enter the body will trigger an immune response in the form of antibodies. In Indonesia, the prevalence of diseases that involve the inflammatory process in the body is high. Freeze-dried hydroxyapatite gypsum puger (HAGP) scaffold is a gypsum powder which is currently under development as a bone replacement material. Freeze-dried hydroxyapatite bovine (HAB) scaffold is a bone substitute material available on the market. Objective: To analyze the inflammatory and immunogenic responses in the tissue after application of freeze-dried HAGP scaffold compared to freeze-dried HAB scaffold through mediators of tumor necrosis factor alpha (TNF-α) and immunoglobulin G (IgG) in rats. Materials and Methods: This study used Wistar rats. HAGP group and HAB group were applied subcutaneously, settled for 7 and 14 days, then the levels of TNF-α and IgG were measured using enzyme-linked immunosorbent assay. Statistical analysis was done using nonparametric test with the Kruskal–Wallis test. Results: TNF-α levels at day 7 in the HAGP group were nearly equal to the control group, while those in the HAB group were higher. Statistically, the significance was P = 0.184 ( P > 0.05). At the 14 th day, the level of IgG on the HAGP and HAB groups the level was higher than the control group, statistically it was found P = 0.127. Conclusion: freeze-dried HAGP scaffold compared to freeze-dried HAB scaffold did not cause inflammatory and immunogenic response on rats through mediators of TNF-α and IgG.

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Indonesian Perspective on Biomaterials and Medical Devices

Cited by 11 publications

References 3 publications

Scaffolds for 3D in vitro culture of neural lineage cells

Scaffolds for 3D in vitro culture of neural lineage cells

Microstructure and microhardness of carbonate apatite particle-reinforced Mg composite consolidated by warm compaction for biodegradable implant application

Inflammatory and immunogenic response of the tissue after application of freeze-dried hydroxyapatite gypsum puger scaffold compared to freeze-dried hydroxyapatite bovine scaffold

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