Indomethacin in the treatment of primary dysmenorrhoea

Abstract

The efficacy of indomethacin, a prostaglandin synthetase inhibitor, in severe dysmenorrhoea was established in a double-blind crossover study using aspirin and placebo as the control drugs. Forty-seven female undergraduates were treated twice with each of the three substances during six consecutive menstrual cycles. Good or moderate relief was achieved in 71% of the cycles treated with indomethacin, in 40% of those treated with aspirin and in 21% of those treated with the placebo. Dizziness and drowsiness were cited by 14 patients (30%) as side-effects of indomethacin, none of these patients discontinued the therapy because all obtained good or moderate relief from dysmenorrhoea. Indomethacin proved to be a valuable agent, and significantly better than aspirin in the treatment of dysmenorrhoea. It allowed many dysmenorrhoeic women to carry out their normal activities and work during the menstrual period.

Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis

“…As a result, we retrieved 121 publications with full length into systematic review and included 70 studies with 72 RCTs of 5723 patients into our network meta-analysis due to the selection criteria as shown earlier. 11 , 12 , 14 – 81 The flowchart of the whole process is shown in…”

Naproxen and Indomethacin in the Treatment of Primary Dysmenorrhea

“…Ever since increased prostaglandin synthesis in the endometrium was shown to be involved in the pathogenesis of dysmenorrhea (3, 4), many antiinflammatory agents that act as prostaglandm synthetase inhibitors (PGSIs) have been used to alleviate dysmenorrheic symptoms (distress). Both indomethacin (1,2) and naproxen (2) have been established as effective in the treatment of dysmenorrhea. In the present study the efficacy of these two drugs was compared, using a doubleblind, cross-over technique.…”