Nonsteroidal anti-inflammatory drugs for primary dysmenorrhoea

Marjoribanks, Jane; Proctor, Michelle; Farquhar, Cindy; Sangkomkamhang, Ussanee S; Derks, Roos S

doi:10.1002/14651858.cd001751

Cited by 120 publications

(94 citation statements)

References 93 publications

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“…While no difference was found between the different nsNSAIDs included in an analysis in terms of efficacy, ibuprofen had the least adverse effects (Marjoribanks et al, 2003 Level I). Paracetamol was less effective than naproxen, ibuprofen, mefenamic acid and aspirin; again, ibuprofen had the most favourable risk-benefit ratio (Zhang & Li Wan Po, 1998 Level I).…”

Section: Chaptermentioning

confidence: 87%

“…Single doses of nsNSAIDs are effective in the treatment of pain after surgery (Derry et al, 2009a Level I; Derry et al, 2009b Level I; Derry et al, 2009c Level I), low back pain (Roelofs et al, 2008 Level I), renal colic (Holdgate & Pollock, 2004 Level I) and primary dysmenorrhoea (Marjoribanks et al, 2003 Level I). For a list of NNTs for each drug see Table 6.1.…”

Section: Efficacymentioning

confidence: 99%

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Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Cohen

Smit

Andrianopoulos³

et al. 2017

Medical Journal of Australia

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Objectives: This study aimed to assess analgesia provided by acupuncture, alone or in combination with pharmacotherapy, to patients presenting to emergency departments with acute low back pain, migraine or ankle sprain. Design: A pragmatic, multicentre, randomised, assessor‐blinded, equivalence and non‐inferiority trial of analgesia, comparing acupuncture alone, acupuncture plus pharmacotherapy, and pharmacotherapy alone for alleviating pain in the emergency department. Setting, participants: Patients presenting to emergency departments in one of four tertiary hospitals in Melbourne with acute low back pain, migraine, or ankle sprain, and with a pain score on a 10‐point verbal numerical rating scale (VNRS) of at least 4. Main outcome measures: The primary outcome measure was pain at one hour (T1). Clinically relevant pain relief was defined as achieving a VNRS score below 4, and statistically relevant pain relief as a reduction in VNRS score of greater than 2 units. Results: 1964 patients were assessed between January 2010 and December 2011; 528 patients with acute low back pain (270 patients), migraine (92) or ankle sprain (166) were randomised to acupuncture alone (177 patients), acupuncture plus pharmacotherapy (178) or pharmacotherapy alone (173). Equivalence and non‐inferiority of treatment groups was found overall and for the low back pain and ankle sprain groups in both intention‐to‐treat and per protocol (PP) analyses, except in the PP equivalence testing of the ankle sprain group. 15.6% of patients had clinically relevant pain relief and 36.9% had statistically relevant pain relief at T1; there were no between‐group differences. Conclusion: The effectiveness of acupuncture in providing acute analgesia for patients with back pain and ankle sprain was comparable with that of pharmacotherapy. Acupuncture is a safe and acceptable form of analgesia, but none of the examined therapies provided optimal acute analgesia. More effective options are needed. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12609000989246.

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Section: Chaptermentioning

confidence: 87%

Section: Efficacymentioning

confidence: 99%

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Cohen

Smit

Andrianopoulos³

et al. 2017

Medical Journal of Australia

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“…The difference between what kind of NSAID (selective, preferential selective, highly selective or non-selective) will be prescribed must respect the systemic conditions of the patient. Other acute and chronic conditions that coxibs are indicated are: odontogenic and post surgical pain, dysmenorrhea, acute conditions, primary dysmenorrhea, musculoskeletal and joint disorders such as arthritis and rheumatic diseases, and as an adjuvant in cancer treatment [39,40].…”

Section: Coxibs In Dentistry: An Updatementioning

confidence: 99%

Inibidores seletivos da cox-2 na odontologia: limitações e efeitos adversos

Souza

Caldas

Silva

2016

Rev. Odonto Ciênc. (Online)

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The coxibs are nonsteroidal anti-inflammatory drugs (NSAIDs) highly selective for COX-2, an enzyme related to inflammatory processes. At first, their use should present advantages over nonselective NSAIDs, since the inflammatory efficacy would be present but with minimal adverse effects. However, its widespread use showed significant cardiovascular risk and, in treatment over 6 months, predisposition to ulceration, bleeding and stomach pain. The coxibs should be used in patients over 60 years, with a history of peptic ulcer or gastrointestinal bleeding, chronic users of corticosteroids and anticoagulants without concomitant cardiovascular risk. Moreover, they are more expensive and have similar analgesic efficacy to non-selective NSAIDs. In dentistry, the main indications are related to the control of pain and inflammation for a maximum of 3 days or preemptively in oral surgery to control pain and swelling. However, there is no major evidence of the benefits of using these drugs compared to traditional NSAIDs in dentistry.Key words: Dentistry; Anti-Inflammatory agents; Cyclooxygenase 2 inhibitors; Adverse effects; Therapeutic use; Contraindications Inibidores seletivos da cox-2 na odontologia: limitações e efeitos adversos ResumoOs coxibes são antiinflamatórios não-esteroidais (AINEs) altamente seletivos para a COX-2, enzima relacionada à processos inflamatórios. A princípio, seu uso deveria apresentar vantagens em relação aos não-seletivos, pois permaneceria a eficácia antiinflamatória com um mínimo de efeitos adversos. Entretanto, sua ampla utilização revelou significativo risco cardiovascular e, em tratamento acima de 6 meses, predisposição à ulcerações, hemorragias e dor gástricas. Sendo recomendado seu uso em pacientes acima de 60 anos, com histórico de úlcera gástrica ou hemorragia digestiva, usuários crônicos de corticosteóides e anticoagulantes. Além disto, são mais caros e possuem eficácia analgésica similar aos AINEs não-seletivos. Em odontologia suas principais indicações estão relacionadas ao controle da dor e da inflamação pelo período máximo de 3 dias ou preemptivamente em cirurgias orais para controle da dor e edema. Entretanto, não há evidências de maiores benefícios da utilização destes fármacos em relação aos AINES tradicionais no manejo odontológico.

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“…12 Effective management of dysmenorrhoea is beneficial for both the afflicted individual and society. Systematic reviews and randomised controlled trials have shown that non steroidal antiinflammatory drugs [13][14][15][16][17] and hormonal regulation through oral contraception 18 are significantly more effective for pain relief than placebo and are often used for symptom control. 19,20 However, some women may not always find them effective or acceptable.…”

Section: Introductionmentioning

confidence: 99%

“…For example, owing to side effects in the case of non-steroidal anti-inflammatory drugs. 13 Non-drug treatments, including alternative and physical Therapies such as topical heat, herbal medicine, thiamine, vitamin E, fish oil, vegetarian diet, low fat diet, acupuncture, acupressure and transcutaneous electrical nerve stimulation (TENS) are increasingly being used for dysmenorrhoea. 21 In different studies the effect of TENS on primary dysmenorrhea, 22 the effect of vibration on chronic backache, 23 and toothache were identified.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vibration and Heat Combination on Primary Dysmenorrhea

2015

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Background: Primary dysmenorrhoea is a common, idiopathic, chronic pelvic pain syndrome, with unknown aetiology which about 50% of women with regular menstrual period suffer. This study was designed to determine the effect of vibration and heat on primary dysmenorrhea. Materials and Methods: In this clinical trial, 75 female students aged 18-22 years old were evaluated for two menstrual cycles. At the first cycle the participants received the routine pain-relief method (synthetic or herbal medicine and traditional remedies). At the second cycle for each participant combined vibration-heat device was applied for ten minutes during menstrual pain. The average of perceived leg pain, lumbar pain and abdominal pain scores at two cycles were determined. The data were analyzed based on Wilcoxon and T tests by using SPSS (v 16.0) for Windows. Results: The average of all perceived pain scores at two cycles were significantly different before pain relief and after both routine methods and using the device (p<0.001). Those were more significantly reduced after using the device in comparison of using routine methods (p<0.001). Conclusion: Since -vibration-heat‖ is an effective pain relief method, it can be used as a complementary alternative medicine in primary dysmenorrhea reduction.

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Nonsteroidal anti-inflammatory drugs for primary dysmenorrhoea

Cited by 120 publications

References 93 publications

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Inibidores seletivos da cox-2 na odontologia: limitações e efeitos adversos

Effect of Vibration and Heat Combination on Primary Dysmenorrhea

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