Indolosesquiterpene alkaloids from the Cameroonian medicinal plant Polyalthia oliveri (Annonaceae)

Kouam, Siméon F.; Ngouonpe, Alain Wembe; Lamshöft, Marc; Talontsi, Ferdinand Mouafo; Bauer, Jonathan O.; Strohmann, Carsten; Ngadjui, Bonaventure T.; Laatsch, Hartmut; Spiteller, Michael

doi:10.1016/j.phytochem.2014.06.015

Cited by 29 publications

(29 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Substitution of the amino hydrogen of the diterpenoid (in compound 1) with the alcoholic group (C 2 H 5 OH) produced a compound (2) with slightly reduced antiplasmodial activity. In another study, three new indolosesquiterpene alkaloids, 8α-polyveolinone (3), N-acetyl-8α-polyveolinone (4), and N-acetyl-polyveoline (5), together with three known compounds, were isolated from the stem bark of Polyalthia oliveri (Annonaceae) by Kouam et al [22]. Compounds 4 and 5 exhibit moderate antiplasmodial activity against P. falciparum NF54 strain with low cytotoxicity on l myoblast (L6) cell line.…”

Section: Terpenoidal and Steroidalmentioning

confidence: 99%

“…Kubo et al [32] isolated a new seco-phenanthroindolizine alkaloid, 4a,b-seco-dehydroantofine (21), and three known phenanthroindolizine alkaloids, dehydrotylophorine (22), dehydroantofine (23), and tylophoridicine D (24), from the twigs of Ficus septica. While compound 21 exhibits a moderate antimalarial activity against the 3D7 strain of P. falciparum with IC 50 value 4.0 μM, the known alkaloids (22)(23)(24) Figure 4. Fadaeinasab et al [33] isolated seven isoquinoline alkaloids from the bark of Actinodaphne macrophylla.…”

Section: Phenanthroindolizine Alkaloidsmentioning

confidence: 99%

See 1 more Smart Citation

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Malaria is one of the major health problems in developing countries. The disease kills a large number of people every year and also affects financial status of many countries. Resistance of the plasmodium parasite, the causative agent, to the existing drugs, including chloroquine, mefloquine, and artemisinin based combination therapy (ACT), is a serious global issue in malaria treatment and control. This warrants an urgent quest for novel compounds, particularly from natural sources such as medicinal plants. Alkaloids have over the years been recognized as important phytoconstituents with interesting biological properties. In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented. Several classes of alkaloids, including terpenoidal, indole, bisindole, quinolone, and isoquinoline alkaloids, were identified with a promising antimalarial activity. It is hoped that the reports of the review work will spur further research into the structural modification and/or development of the interesting compounds as novel antimalarial drugs.

show abstract

Section: Terpenoidal and Steroidalmentioning

confidence: 99%

Section: Phenanthroindolizine Alkaloidsmentioning

confidence: 99%

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Moreover, Kouam et al. (2014) isolated and described from the stem bark of G. oliveri , the first group of indolosesquiterpernes having a biosynthetic pathway (17‐methyl in the α orientation) different from that of previously published analogues [3] . In fact, the genus Greenwayodendron which comprises about 120 species worldwide, is one of the most important genera in its family as it produces compounds with challenging structural scaﬀolds, complicated frameworks as well as significant bioactivities [4] .…”

Section: Introductionmentioning

confidence: 99%

Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids with an Eight‐Membered Lactam Ring from Greenwayodendron oliveri

et al. 2021

View full text Add to dashboard Cite

Three new sesquiterpene alkaloids of the polyveoline type containing eight‐membered lactam rings named greenwaylactam A (1), B (2) and C (3) were isolated from the leaves of a Cameroonian medicinal plant Greenwayodendron oliveri (Engl.) Verdc along with three known compounds diacetylpolyveoline (4), N‐acetyl‐8α‐polyveolinone (5) and methyl pheophorbide‐A (6). These comprise the first members of a new class of ξ‐lactam sesquiterpenes. Compounds were isolated by means of successive column chromatographies and their structures were elucidated by extensive NMR spectroscopic analyses and HRESIMS. The configuration of 1 was deduced from its single‐crystal X‐ray diffraction. The crude extract and some isolated compounds were assessed for their antibacterial activity against four enteric bacterial strains Escherichia coli, Salmonelles typhi, Shigella dysenterie and Klebseilla pneumonie using the micro‐dilution method. Compounds 1, 2, 5 and 6 were the most active with MIC values varying between 31.25–250 μg/mL.

show abstract

“…Similarly, this diversity can also be seen in its wide range of phyto-constituents. Phytochemical studies of this family have reported the presence of alkaloid (Malebo et al, 2013 ; Kouam et al, 2014 ; Soares et al, 2015 ), cyclopeptides (Wu P. et al, 2014 ; Moghadamtousi et al, 2015 ), flavonoids (Lage et al, 2014 ; Chokchaisiri et al, 2015 ), terpenoids (Annan et al, 2013 ; Rabelo et al, 2016 ), and lignans (Moreira et al, 2013 ; Nguyen et al, 2015 ; Rayanil et al, 2016 ). Several bioactivities including antimalarial (Frausin et al, 2014 ; Meira et al, 2015 ), antiplatelet, (Thang et al, 2013a ; González-Esquinca et al, 2014 ), and anti-inflammatory activity (Kandimalla et al, 2016 ) are just to name a few.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Annonaceae: Breaking the Wall of Inflammation

2017

View full text Add to dashboard Cite

Inventories of tropical forests have listed Annonaceae as one of the most diverse plant families. For centuries, it is employed in traditional medicines to cure various pathological conditions including snakebite, analgesic, astringent, diarrhea, dysentery, arthritis pain, rheumatism, neuralgia, and weight loss etc. Phytochemical analysis of Annonaceae family have reported the occurrence of alkaloids, flavonoids, triterpenes, diterpenes and diterpene flavone glycosides, sterols, lignans, and annonaceous acetogenin characteristically affiliated with Annonaceae sp. Numerous past studies have underlined the pleotropic pharmacological activities of the crude extracts and isolated compounds from Annonaceae species. This review is an effort to abridge the ethnobotany, morphology, phytochemistry, toxicity, and particularly focusing on the anti-inflammatory activity of the Annonaceae species.

show abstract

Indolosesquiterpene alkaloids from the Cameroonian medicinal plant Polyalthia oliveri (Annonaceae)

Cited by 29 publications

References 23 publications

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids with an Eight‐Membered Lactam Ring from Greenwayodendron oliveri

Annonaceae: Breaking the Wall of Inflammation

Contact Info

Product

Resources

About