Annonaceae: Breaking the Wall of Inflammation

Attiq, Ali; Jalil, Juriyati; Husain, Khairana

doi:10.3389/fphar.2017.00752

Cited by 36 publications

(37 citation statements)

References 221 publications

(203 reference statements)

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“…Another important compound is acetogenin. Annonaceous acetogenins are a group of potential anti-neoplastic agents isolated from Annonaceae plants because of their strong cytotoxic activity (Yuan et al, 2006;Attiq et al, 2017). Their cytotoxicity is mediated by the depletion of A TP levels via the inhibition of NA DH-ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport system (Zafra -Polo et al, 1998;Yuan et al, 2003;Yuan et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

In vitro cytotoxicity of Duguetia sp extracts on Ehrlich tumor cells

et al. 2020

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The genus Duguetia, of the Annonaceae family, includes around 100 species that have been used in folk medicine to treat several diseases. Its phytochemical compounds have been researched for their antifungal, antioxidant, antigenotoxic, anti-inflammatory and cytotoxic properties. Therefore, the objective of the present study was to conduct a preliminary study on the biological effects of Duguetia sp extracts by evaluating their in vitro cytoto xic effect on different cell types. To prepare the methanolic extract (ME), the leaves were macerated with 80% methanol. Part of the ME was dissolved in 10% phosphoric acid, and the acidic aqueous solution was partitioned with dichloromethane. The organic phase was evaporated to obtain an acetogenin-rich extract (ACE). The extracts were diluted in RPMI culture medium , supplemented with 20% fetal bovine serum , and added to Erhlich tumor cells or mice spleen cells at different concentrations: the ACE e xtract a t 1.35 mg mL-1 , 0.67 mg mL-1 or 0,34 mg mL-1 , and the ME e xtract at 1.40 mg mL-1 , 0.70 mg mL-1 or 0,35 mg mL-1. After 24 h, cytotoxicity analysis was performed using the Trypan Blue exclusion method. The results demonstrated that the extracts are cytotoxic at all concentrations to Ehrlich tumor cells and mice spleen cells. According to the results, we concluded that the extracts of Duguetia sp had a cytotoxic effect on the studied cells in vitro. This was the first study to report the biological effect of this plant genus in this type of cells; however, further study is needed to determine the current species used and the compounds present in the extracts.

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Section: Resultsmentioning

confidence: 99%

In vitro cytotoxicity of Duguetia sp extracts on Ehrlich tumor cells

et al. 2020

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“…Consistent with the former, effects of A. squamosa were significantly enhanced by cAMP phosphodiesterase inhibition using IBMX. Interestingly, traditional use of A. squamosa in asthma treatment [ 37 ] involves elevation of cAMP in bronchial smooth muscles, relaxing the airway passage and downregulating cellular replication in smooth muscles [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals

Ansari

Flatt

Harriott

et al. 2020

Plants

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Annona squamosa is generally referred to as a ‘custard apple’. Antidiabetic actions of hot water extract of Annona squamosa (HWAS) leaves together with isolation of active insulinotropic compounds were studied. Insulin release, membrane potential and intracellular Ca2+ were determined using BRIN-BD11 cells and isolated mouse islets. 3T3L1 adipocytes and in vitro models were used to determine cellular glucose uptake, insulin action, starch digestion, glucose diffusion, DPP-IV activity and glycation. Glucose intolerant high-fat fed rats were used for in vivo studies. Active compounds were isolated and characterized by HPLC, LCMS and NMR. HWAS stimulated insulin release from clonal β-cells and mouse islets. Using fluorescent indicator dyes and modulators of insulin secretion, effects could be attributed to depolarization of β-cells and influx of Ca2+. Secretion was stimulated by isobutylmethylxanthine (IBMX), tolbutamide or 30 mM KCl, indicating additional non-KATP dependent pathways. Extract stimulated cellular glucose uptake and insulin action and inhibited starch digestion, protein glycation, DPP-IV enzyme activity and glucose diffusion. Oral HWAS improved glucose tolerance and plasma insulin in high-fat fed obese rats. Treatment for 9 days with HWAS (250 mg/5 mL/kg), partially normalised energy intake, body weight, pancreatic insulin content, and both islet size and beta cell mass. This was associated with improved oral glucose tolerance, increased plasma insulin and inhibition of plasma DPP-IV activity. Isolated insulinotropic compounds, including rutin (C27H30O16), recapitulated the positive actions of HWAS on beta cells and in vivo glucose tolerance and plasma insulin responses. Annona squamosa is attractive as a dietary adjunct in treatment of T2DM and as a source of potential antidiabetic agents including rutin.

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“…Annonaceae is among the largest planet family with more than 3,000 species. Many of its species are famous in regions of rain forest due to wide range of medicinal activities (Attiq et al, 2017 ). Dillenia serrate is also popular among Malaysian peninsular region due to its medicinal activity against internal hemorrhage, rheumatism, generalized body pain and inflammation (Jain, 1994 ; Panda, 2004 ).…”

Section: Natural Cox-2 and Pge 2 Inhibitor Past Pmentioning

confidence: 99%

“…The natural products with medicinal properties have been used to treat all sorts of inflammatory conditions (Petrovska, 2012 ; Daniel, 2016 ). These traditional anti-inflammatory remedies later become the counter stones for the production of Aspirin, the first natural product derived synthetic anti-inflammatory drug (Attiq et al, 2017 ). Since then the exploration of natural bioactive compounds has been quite promising, resulting in the discovery of numinous secondary metabolites with extra ordinary bioactivities including artemisinin (Dewick, 2002 ), vinblastine (Cragg et al, 1997 ), pilocarpine etc (Patwardhan et al, 2004 ; Zhang L. et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Raging the War Against Inflammation With Natural Products

et al. 2018

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Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of choice for treating numerous inflammatory diseases including rheumatoid arthritis. The NSAIDs produces anti-inflammatory activity via inhibiting cyclooxygenase enzyme, responsible for the conversation of arachidonic acid to prostaglandins. Likewise, cyclooxegenase-2 inhibitors (COX-2) selectively inhibit the COX-2 enzyme and produces significant anti-inflammatory, analgesic, and anti-pyretic activity without producing COX-1 associated gastrointestinal and renal side effects. In last two decades numerous selective COX-2 inhibitors (COXIBs) have been developed and approved for various inflammatory conditions. However, data from clinical trials have suggested that the prolong use of COX-2 inhibitors are also associated with life threatening cardiovascular side effects including ischemic heart failure and myocardial infection. In these scenario secondary metabolites from natural product offers a great hope for the development of novel anti-inflammatory compounds. Although majority of the natural product based compounds exhibit more selectively toward COX-1. However, the data suggest that slight structural modification can be helpful in developing COX-2 selective secondary metabolites with comparative efficacy and limited side effects. This review is an effort to highlight the secondary metabolites from terrestrial and marine source with significant COX-2 and COX-2 mediated PGE2 inhibitory activity, since it is anticipated that isolates with ability to inhibit COX-2 mediated PGE2 production would be useful in suppressing the inflammation and its classical sign and symptoms. Moreover, this review has highlighted the potential lead compounds including berberine, kaurenoic acid, α-cyperone, curcumin, and zedoarondiol for further development with the help of structure–activity relationship (SAR) studies and their current status.

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Annonaceae: Breaking the Wall of Inflammation

Cited by 36 publications

References 221 publications

In vitro cytotoxicity of Duguetia sp extracts on Ehrlich tumor cells

In vitro cytotoxicity of Duguetia sp extracts on Ehrlich tumor cells

Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals

Raging the War Against Inflammation With Natural Products

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