Indolent mucoid carcinoma of stomach

Brander, W. L.; Needham, P. R. G.; Morgan, A. D.

doi:10.1136/jcp.27.7.536

Cited by 25 publications

(18 citation statements)

References 5 publications

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“…Alteration in mucin expression has been reported (Sakamoto et al, 1997) and such abnormality was proposed as a potentially informative molecular marker of increased risk of malignant transformation in intestinal metaplasia (Reis et al, 1999). In 1971, Paile first reported a significantly poorer survival rate in patients with mucus-rich tumours (Paile, 1971), and two later reports demonstrated that signet ring carcinomas, which are rich in intracellular mucus, have a worse prognosis than well-differentiated carcinomas sitting in lakes of extracellular mucus (Brander et al, 1974;Ishii et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of Goseki histological classification in adenocarcinoma of the cardia

et al. 2003

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Various histologic classification systems have been proposed as prognostic factors for gastric cancer. We assessed the prognostic value of Goseki classification as well as the TNM staging system, histological tumour grading, Lauren, WHO, Goseki and Siewert classifications in 100 patients with cardia carcinoma undergoing curative surgery. Two patients were lost at follow-up. The median time of follow-up in the remaining patients was 32.9 months after surgery (range: 0.1 -142.1 months). No differences in survival rates were observed according to tumour grading, Lauren or WHO histologic or Siewert topographical classification. No differences were found according to Goseki classes, when considering either the mucin content of the carcinoma (types I and III vs II and IV) or the differentiation grade (types I and II vs III and IV). Multivariate analysis showed that the only lymph node positivity was a significant predictor of survival: 7.2% of patients with, but 41.5% of those without nodal involvement were alive after five years (P ¼ 0.0001). In conclusion, we found no prognostic role for Goseki or the traditional histological indexes, while the TNM staging system and particularly lymph node positivity were the main predictors of survival in patients with cardia adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of Goseki histological classification in adenocarcinoma of the cardia

et al. 2003

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“…Bochard [13] also reported that the prognosis of MGC is not related to its histologic type. However, Brander et al [2] suggested that MGC had a more favorable prognosis than NMGC. Kinosita et al [14]found no significant difference in the 5-survival rates of patients with different histologic types, but reported individuals with NMGC had an improved survival rate compared with MGC patients when followed for more years.…”

Section: Discussionmentioning

confidence: 99%

“…MGC is a histopathologic subtype of gastric adenocarcinoma with an incidence of 3–10% of gastric carcinomas and was thought to have a poor prognosis [1, 2, 3, 8]. The definition of MGC by the WHO International Histologic Classification is: ‘an adenocarcinoma in which a substantial amount of extracellular mucin (more than 50% of the tumor) is retained within the tumor’ [9].…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathologic Features of Mucinous Gastric Carcinoma

Woo

Kim

et al. 2002

Dig Surg

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Background/Aims: Mucinous gastric carcinoma (MGC) is a histopathologic subtype of gastric carcinoma with a poor prognosis. The purpose of this study was to compare the disease course of MGC with non-mucinous gastric carcinoma (NMGC) and study the clinicopathologic features that influence the prognosis of MGC patients. Methods: We reviewed the records of 2,383 patients with a confirmed histologic diagnosis of gastric carcinoma. There were 157 patients with MGC compared to 2,226 with NMGC. Results: A depth of invasion greater than T3 was more frequently found in MGC than in NMGC. The mean number of lymph nodes with metastases was 2.78 in MGC and 2.28 in NMGC (p < 0.001). There were more MGC patients with TNM stages II through IV (UICC classification). The overall survival rate was lower for the MGC group (46.5%) than for the NMGC group (64.0%; p < 0.05). Depth of invasion, lymph node metastases, and stage at diagnosis were significant factors affecting the outcome. Conclusion: The factors influencing the poorer prognosis (lower 5-year survival rate) of MGC are the advanced stage at the time of diagnosis, lymph node metastases, and a higher TNM status. Mucinous histologic type itself was not an independent predictive factor in survival.

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“…There are few comprehensive studies on MGC, and its clinicopathologic and prognostic characteristics are still unclear [3,4]. Some studies indicate that prognosis of patients with MGC is poor [1], whereas others suggest that the biologic behavior of MGC is similar to that of ordinary gastric carcinoma [2].…”

Section: Introductionmentioning

confidence: 99%