Clinicopathologic Features of Mucinous Gastric Carcinoma

Abstract

Background/Aims: Mucinous gastric carcinoma (MGC) is a histopathologic subtype of gastric carcinoma with a poor prognosis. The purpose of this study was to compare the disease course of MGC with non-mucinous gastric carcinoma (NMGC) and study the clinicopathologic features that influence the prognosis of MGC patients. Methods: We reviewed the records of 2,383 patients with a confirmed histologic diagnosis of gastric carcinoma. There were 157 patients with MGC compared to 2,226 with NMGC. Results: A depth of invasion greater than T3 was more frequently found in MGC than in NMGC. The mean number of lymph nodes with metastases was 2.78 in MGC and 2.28 in NMGC (p < 0.001). There were more MGC patients with TNM stages II through IV (UICC classification). The overall survival rate was lower for the MGC group (46.5%) than for the NMGC group (64.0%; p < 0.05). Depth of invasion, lymph node metastases, and stage at diagnosis were significant factors affecting the outcome. Conclusion: The factors influencing the poorer prognosis (lower 5-year survival rate) of MGC are the advanced stage at the time of diagnosis, lymph node metastases, and a higher TNM status. Mucinous histologic type itself was not an independent predictive factor in survival.

Clinicopathological Characteristics and Computed Tomography Features of Mucinous Gastric Carcinoma

“…Kawamura et al 1 reported that MGC was frequently observed in younger patients and that most MGC were located in the lower third of the stomach. However, the results of the present study, and studies by other investigators, 2,3,12 have shown no significant differences between MGC and NGC in age and tumour location.…”

“…3,12 Kawamura et al 1 also reported that MGC patients had a higher frequency of peritoneal metastasis than NGC patients, whereas the results of Woo et al 2 showed no significant difference between MGC and NGC, in this measure. Peritoneal metastasis was not included in the present investigation because of the small sample size.…”

Gastric Cancer histology: Clinicopathologic characteristics and prognostic value

“…Thus, previous reports on SRC or MC have involved comparative analyses of SRC and MC versus non-SRC or non-MC [1,2,[13][14][15][16][17]. However, SRC and MC tumors have much in common as they are both undifferentiated and mucin-producing.…”

“…Moreover, although these histologic subtypes have been well studied, it is still debatable as to how their histologic types are related to clinicopathologic findings and outcome [1,2].…”

Neoadjuvant chemotherapy with S-1 and surgical resection for a mucinous gastric cancer with peritoneal dissemination

“…In our patient, the tumor had massive peritoneal dissemination, and its histological type was mainly mucinous gastric carcinoma. In general, this histological type has been reported to be more advanced in stage at the time of diagnosis, with a higher rate of peritoneal dissemination than nonmucinous gastric carcinomas [16][17][18]. Some reports indicate no difference in prognosis between patients with mucinous and nonmucinous gastric cancer [19,20].…”