Gastric Cancer histology: Clinicopathologic characteristics and prognostic value

Zhu

Journal of Surgical Oncology

et al. 2010

“…The incidence of MGC has been reported variously from 2.6% to 3.5% [1][2][3][4]. In the present study, MGC was diagnosed in 3.8% of gastrectomy specimens.…”

Section: Discussionmentioning

confidence: 47%

“…Mucinous gastric carcinoma (MGC) is a rare histopathological type of gastric cancer, comprising 2.6% to 3.5% of gastric carcinomas [1][2][3][4]. These tumors are detected mostly in an advanced stage and rarely in an early stage.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic characteristics and prognosis of mucinous gastric carcinoma

Zhu

Journal of Surgical Oncology

et al. 2010

“…In all three subtypes, a clear-cut concentration of prognostically favorable parameters was observed, compared to remaining non-low grade cohesive (100 cases), diffuse (59), and mucinous (23) cancers (Table 4). It should be added that the 99 tumors showing invasion confined within the muscularis propria included 22 (47%) HLR, six (60%) well-differentiated tubular, nine (60%) low grade diffuse desmoplastic, and 15 (75%) muconodular cases.…”

Section: Resultsmentioning

confidence: 92%

A combined histologic and molecular approach identifies three groups of gastric cancer with different prognosis

et al. 2009

The limited prognostic value of currently used histologic classifications of gastric cancer and their failure to account for the complexity of the disease as revealed by more recent investigations prompted a combined reinvestigation of histologic, molecular, and clinicopathologic patterns in 294 extensively sampled, invasive gastric cancers representing all main histotypes and stages of the disease and followed for a median of 150 months. Among histologic parameters tested, only cellular atypia, angio-lympho- or neuroinvasion, Ki67 proliferation index, expansile/infiltrative type growth, and T8 cell-rich high lymphoid intra-/peritumor response (HLR) proved to be stage-independent predictors of patient survival. Among molecular tests, p53 gene exon 7 (loop 3) and 8 (loop-sheet-helix motif and S-10 band), but not p53 protein overexpression, TP53 LOH or 18qLOH, were found to worsen prognosis. Microsatellite DNA instability was a favorable prognostic factor when coupled with HLR. Patient survival analysis of the main histotypes and their subtypes confirmed the favorable prognosis of HLR, well-differentiated tubular, muconodular, and low grade diffuse desmoplastic cancers, and highlighted the worse prognosis of anaplastic and infiltrative-lymphoinvasive mucinous cancers compared to ordinary cohesive and diffuse cancers. Distinct roles of individual morphologic and molecular factors in tumor progression of the different histotypes have been recognized. The combination of survival-predictive histotypes and individual histologic or molecular parameters allowed us to develop a classification of all gastric cancers into three grades of increasing malignancy which proved to be of high prognostic value.

Journal of Surgical Oncology

“…Gastric cancer is one of the most common gastrointestinal tumors in the world and causes the second most common cancer-related death in Asia [11]. Recent data showed increased number of Treg either in the circulation or tumor microenvironment of gastric cancer patients [12,13].…”

Section: Foxp3mentioning

confidence: 99%

Conversion of intratumoral regulatory T cells by human gastric cancer cells is dependent on transforming growth factor‐β1

Liu

et al. 2011