Clinicopathologic characteristics and prognosis of mucinous gastric carcinoma

Zhang, Ming; Zhu, Guanyu; Zhang, Hongfeng; Gao, Hongyu; Han, Xiaofeng; Xue, Yingwei

doi:10.1002/jso.21533

Cited by 28 publications

(23 citation statements)

References 15 publications

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“…Zhang et al (6) suggested that tumor size, depth of invasion and lymph node metastasis were not associated with MGC and NMGC. However, we observed that MGC and NMGC differed in tumor size, macroscopic type, lymphovascular invasion, peritoneal metastasis and TNM stage, which was in agreement with the findings of Adachi et al (7) and Yin et al (14).…”

Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

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Characteristics and prognosis of mucinous gastric carcinoma

Isobe

Hashimoto

Kizaki

et al. 2014

Molecular and Clinical Oncology

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Abstract. Mucinous gastric carcinoma (MGC) is a rare histological subtype of undifferentiated gastric carcinoma, accounting for ~2.6-6.6% of all gastric cancer cases. The clinicopathological characteristics and prognosis of MGC are controversial. The present study aimed to determine the clinicopathological characteristics and prognosis of patients with MGC. We retrospectively compared the characteristics and postoperative survival of 70 patients with MGC and 2,492 non-MGC (NMGC) cases who underwent surgical resection between 1990 and 2010. MGC was characterised by larger tumor size, macroscopic Borrmann type 2 and 3, T4 invasion of the gastric wall, positive N2 and N3 lymph node metastasis, positive lymphatic vessel invasion, positive venous invasion, peritoneal metastasis and advanced tumor stage III and IV. The prognosis of MGC patients was worse compared to that of NMGC patients, as the former group consisted of more advanced-stage cases. When patients with similar disease stages were compared, the incidence of peritoneal metastasis was significantly higher among MGC patients. However, hepatic metastasis was found significantly more often in NMGC patients. Otherwise, the prognosis of MGC and NMGC patients with similar disease stages was not significantly different. Therefore, our findings indicated that, although MGC is more rare and mostly detected at an advanced stage, the diagnosis of the mucinous histological subtype was not an independent prognostic factor.

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Section: Univariate Analysis Multivariate Analysis ------------------mentioning

confidence: 99%

“…Undifferentiated gastric carcinomas are generally associated with a worse prognosis (3). Mucinous gastric carcinoma (MGC) is a rare histological subtype of undifferentiated gastric carcinoma, accounting for 2.6-6.6% of all gastric cancer cases (4)(5)(6)(7)(8). The available literature on MGC is currently limited, mostly due to its rarity.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and prognosis of mucinous gastric carcinoma

Isobe

Hashimoto

Kizaki

et al. 2014

Molecular and Clinical Oncology

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“…The innate characteristics and prognosis of MAC and SRC have been studied [5-18]. However, the results of those studies are still debated.…”

Section: Introductionmentioning

confidence: 99%

Undifferentiated-type gastric adenocarcinoma: prognostic impact of three histological types

et al. 2012

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BackgroundThe prognostic value of the three constituents of undifferentiated-type gastric adenocarcinoma remains unclear. The present study assessed the clinicopathological characteristics and prognosis of undifferentiated-type mucinous adenocarcinoma (uMAC) and signet ring cell carcinoma (SRC) compared with those of poorly differentiated adenocarcinoma (PDAC).MethodsIn total, 1,376 patients with undifferentiated-type gastric adenocarcinoma were included, consisting of 1,002 patients diagnosed with PDAC, 54 with uMAC and 320 with SRC. Clinicopathological factors and survival rates were compared among the three histological types.ResultsSignificant differences in the distribution of pathological stages were observed among the groups. Patients with SRC had a significantly better survival rate than those with PDAC or uMAC, in both the all patients including non-curative resected patients and curative-resected groups. In addition, there was significant difference in survival between the PDAC and uMAC groups. Multivariate analysis suggested that age, gender, tumor depth, lymph node metastasis and curability significantly affected survival. Histological type was not an independent prognostic factor. There was no significant difference in the pattern of recurrence among the three groups.ConclusionsThe uMAC and SRC had worse and favorable prognosis compared with PDCA, respectively. However, there were no differences in survival by pathological stage, thus histological type was not an independent predictor of prognosis.

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“…It has also been reported that the incidence of early cases was only 20.0% in MGC, while among other pathological types of carcinoma, 44.6% were diagnosed at an early stage [4]. In contrast to these reports, some investigators have reported a similar incidence of early MGC and early NMGC cases (10.4% vs. 10.8%) [11]. In the present study, early MGC cases were 14.4% of all early gastric carcinoma cases.…”

Section: Discussionmentioning

confidence: 99%

“…Several hypotheses have been proposed to explain why MGC is almost always diagnosed at a late stage [15]. In contrast, some investigators have found no significant difference between the overall survival rates of early MGC and early NMGC [11,13]. Furthermore, some studies have reported that the surgical outcome is better for patients with early MGC than for patients with early NMGC [7,12].…”

Section: Discussionmentioning

confidence: 99%

Prognosis of early mucinous gastric carcinoma

et al. 2014

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PurposeLittle is known about the clinicopathological features of early mucinous gastric carcinoma (MGC). The purpose of this study was to compare the clinicopathological features and prognosis between patients with early MGC and those with early nonmucinous gastric carcinoma (NMGC).MethodsWe reviewed the records of 2,732 patients diagnosed with gastric carcinoma who were treated surgically. There were 14 patients (0.5%) with early MGC and 958 with early NMGC.ResultsEarly MGC patients had a higher prevalence of elevated type (71.4%) compared with early NMGC patients (29.5%). More early MGC patients had submucosal carcinoma, compared with early NMGC patients (78.6% vs. 64.1%). The overall 5-year survival of the patients with early MGC was 97.2% as compared with 92.7% for the patients with early NMGC (P < 0.01). The statistically significant prognostic parameters influencing the 5-year survival rate according to Cox's proportional hazard regression model were: age (risk ratio, 2.22; 95% confidence interval [CI], 1.62-3.04; P < 0.01); sex (risk ratio, 1.97; 95% CI, 1.42-2.73; P < 0.01); and lymph node metastases (risk ratio, 1.88; 95% CI, 1.28-2.77; P < 0.01).ConclusionPatients with early MGC had a better prognosis than those with early NMGC. Mucinous histology itself appears not to be an independent prognostic factor. Therefore, early detection is important for improving the prognosis for patients with gastric carcinoma regardless of tumor histology.

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Clinicopathologic characteristics and prognosis of mucinous gastric carcinoma

Abstract: MGC is rare and detected mostly in an advanced stage. Mucinous histology type itself is not an independent prognostic factor.

Cited by 28 publications

References 15 publications

Characteristics and prognosis of mucinous gastric carcinoma

Characteristics and prognosis of mucinous gastric carcinoma

Undifferentiated-type gastric adenocarcinoma: prognostic impact of three histological types

Prognosis of early mucinous gastric carcinoma

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