Indole core-based Copper(II), Cobalt(II), Nickel(II) and Zinc(II) complexes: Synthesis, spectral and biological study

Yernale, Nagesh Gunavanthrao; Matada, Basavarajaiah Suliphuldevara; Vibhutimath, G.B.; Biradar, Vivekanand; Karekal, Mahendra Raj; Udayagiri, Mahadev Dhanraj; Mruthyunjayaswamy, B. H. M.

doi:10.1016/j.molstruc.2021.131410

Cited by 27 publications

(11 citation statements)

References 34 publications

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“…Mani et al recent review [16] summarized the available indole-derived AhR ligands includes information on natural and dietary substances, synthetic substances, including drugs utilized in clinical study, endogenous intermediary metabolites, and catabolites produced by human microbiota. In light of the aforementioned findings and as part of our ongoing research, [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] it is suggested that the current review provide a general overview of the various research initiatives taking place in this expanding field. Additionally, the review's notch provides information on recent investigations of biologically requisite indole derivatives.…”

Section: Introductionmentioning

confidence: 99%

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

Mathada¹,

Yernale

Basha³

2023

ChemistrySelect

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Heterocycles are a privileged motif that appears as a momentous objective in medicinal chemistry. An important class of compounds for drug discovery and design is indole and its derivatives, which have been examined for a variety of biological activities. Therefore, it is noteworthy in the modern progress of synthetic, medicinal chemistry; the last decade has been onlooker with a multitude of reports on several indole derivatives corroborating these chemical entities to be a renowned target for the discovery of new drugs. The current study includes brief natural sources of indole, and a new range of commercially available indole‐based drugs. Additionally, this review discusses the numerous facets of the structure‐activity relationship study (SARs) and provides information about the varied pharmacological effects of indole derivatives. The literature data presented for the anti‐pharmacological agents herein covers largely from the year 2015 to mid of 2022.

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Section: Introductionmentioning

confidence: 99%

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

Mathada¹,

Yernale

Basha³

2023

ChemistrySelect

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“…The diverse geometry of these complexes and their ability to exchange ligands, combined with the therapeutic properties of metal ions and ligands, can lead to the synthesis of many new therapeutics with properties that are not found in the ligands alone. Zn complexes are known for their antimicrobial [ 23 , 24 , 25 , 26 , 27 , 28 ], anticancer [ 29 , 30 ], and antioxidant properties [ 24 , 30 , 31 , 32 , 33 , 34 , 35 ]. The therapeutic effects of drug–metal complexes are not only often comparable to those of conventional drugs, but they are also more active, selective, bioavailable, and have fewer side effects [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure and Biological Activity of Indole–Imidazole Complexes with ZnCl2: Can Coordination Enhance the Functionality of Bioactive Ligands?

et al. 2023

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The ability of the indole–imidazole hybrid ligands to coordinate with the Zn(II) ion and the resulting structures of this new class of coordination compounds were analyzed in order to determine their structural properties and biological functionalities. For this purpose, six novel Zn(II) complexes, [Zn(InIm)2Cl2] (1), [Zn(InMeIm)2Cl2] (2), [Zn(IniPrIm)2Cl2] (3), [Zn(InEtMeIm)2Cl2] (4), [Zn(InPhIm)2Cl2] (5) and [Zn2(InBzIm)2Cl2] (6) (where InIm is 3-((1H-imidazol-1-yl)methyl)-1H-indole), were synthesized by the reactions of ZnCl2 and the corresponding ligand in a 1:2 molar ratio in methanol solvent at an ambient temperature. The structural and spectral characterization of these complexes was performed using NMR, FT–IR and ESI–MS spectrometry and elemental analysis, and the crystal structures of 1–5 were determined using single-crystal X-ray diffraction. Complexes 1–5 form polar supramolecular aggregates by utilizing, for this purpose, the N-H(indole)∙∙∙Cl(chloride) intermolecular hydrogen bonds. The assemblies thus formed differ depending on the distinctive molecular shape, which can be either compact or extended. All complexes were screened for their hemolytic, cytoprotective, antifungal, and antibacterial activities. The results show that the cytoprotective activity of the indole/imidazole ligand significantly increases upon its complexation with ZnCl2 up to a value comparable with the standard antioxidant Trolox, while the response of its substituted analogues is diverse and less pronounced.

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“…11 Schiff bases such as N,N 0 -ethene-bis(salicylideneimine) formed complexes with divalent ions of copper, cadmium, and mercury and these complexes has been reacted with other transition metal ions to give homo bi-and hetero binuclear complexes. 12 On the other hand, work has been done concerning synthesis of new synthesis of ligands able to make two metal atoms into close proximity through complex formation. 13,14 The Schiff bases created from amines or diamines and 3-formylsalicylic acid were discovered to be good binucleating ligands.…”

Section: Introductionmentioning

confidence: 99%

“…Werner was the first to construct binuclear complexes and noticed that the color of these complexes was significantly deeper than that of the comparable mononuclear complexes of these metal ions 11 . Schiff bases such as N,N′‐ethene‐bis(salicylideneimine) formed complexes with divalent ions of copper, cadmium, and mercury and these complexes has been reacted with other transition metal ions to give homo bi‐ and hetero binuclear complexes 12 . On the other hand, work has been done concerning synthesis of new synthesis of ligands able to make two metal atoms into close proximity through complex formation 13,14 …”

Section: Introductionmentioning

confidence: 99%

Studies on the synthesis, spectroscopy, thermal properties, docking, and biology of new Schiff base and its mono‐ and binuclear complexes

Abou‐Melha

2023

J of Molecular Recognition

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A novel Schiff base has been synthesized from the condensation of the 3‐formyl‐2‐hydroxybenzoic acid and 4‐nitrobenzene‐1,2‐diamine. The new ligand was found to have two coordination sites. So, it has the capability to form mono‐ and binuclear complexes with different metal ions. The free ligand and its mono‐ and binuclear cobalt(II) complexes have been characterized by UV–Visible spectra, IR, elemental analyzes, H1 NMR, conductimetric, thermal, and magnetic measurements. Results indicated that the cobalt(II) ion is attached to the inside coordination site and the second metal ion attached to the outside coordination site. The complexes are all non‐electrolytes, as demonstrated by the molar conductance tests. The thermodynamic parameters of the metal complexes are calculated using Horowitz Metzger and Coats‐Redfern methods. The complexes' bonding properties have also been estimated. Molecular docking was employed to forecast the interaction of the prepared with the Candida‐albicans receptor (1zap). The biological activities of these metal complexes were tested against some bacteria and fungi. It is evident from the biological screening data that the prepared Co(II) binuclear complexes exhibit predominant activity against Candida albicans, Penicillium oxalicum and Escherichia coli, while they have no activity against Micrococcus roseus and Micrococcus luteus.

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Indole core-based Copper(II), Cobalt(II), Nickel(II) and Zinc(II) complexes: Synthesis, spectral and biological study

Cited by 27 publications

References 34 publications

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

Synthesis, Structure and Biological Activity of Indole–Imidazole Complexes with ZnCl2: Can Coordination Enhance the Functionality of Bioactive Ligands?

Studies on the synthesis, spectroscopy, thermal properties, docking, and biology of new Schiff base and its mono‐ and binuclear complexes

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