Indole based multicomponent reactions towards functionalized heterocycles

Abstract

This short review offers a non-exhaustive panorama of the indole ring implicated multicomponent reactions, and simple functional group transformation-based approaches, developed over the last thirty years for the synthesis of various biologically interesting indole heterocyclic ring systems.

Multicomponent reactions for the synthesis of pyrroles

“…the frontiers of organic synthesis. While a large part of the work developed in this field is focused on reactions using isonitriles as one of the starting materials and leading to peptide-like structures, recent years have witnessed a steady growth in the development of MCRs that lead directly to heterocycles, [13][14][15][16] the most important single class of compounds in the development of bioactive substances.…”

Microwave-assisted synthesis of novel 1-{[(diindolyl)methyl]benzyl}-2-{[(diindolyl)methyl]phenyl}-1H-benzimidazole scaffold via two-consecutive multicomponent reaction

“…Therefore, in the search of a new synthetic design for creating molecular complexity and diversity with maximum simplicity, multicomponent reactions (MCR) have been ideally considered the best choice owing to © AUTHOR(S) their intrinsic green character, great exploratory power, and economic advantages over the orthodox multistep synthesis. [11][12][13][14] Benzimidazole is an important structural core in pharmaceutical chemistry, where it has been used in antitumor, 15 antiparasitic, 16 antimicrobial, 17 and antihistaminic agents. 18 Benzimidazole derivatives with short peptide sequences have antidiabetic, antibiofilm, and antioxidant activities.…”

Synthetic Strategies for Hydrazinyl Thiazole Derivatives

“…Moreover, according to the definition of “Ideal Synthesis” by Wender [30] a reaction is ‘ideal’ in which one‐step production of the target components, in quantitative yield, is achieved from easily available and inexpensive starting materials, under environment friendly, and benign process. One‐pot Multicomponent reactions (MCR) are a possible tool to achieve ideal to near ideal synthesis, as they possess some of the aforesaid criteria for building up complex molecules with maximum simplicity [31–35] …”