2012
DOI: 10.1016/j.phytochem.2011.09.012
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Indole alkaloids from Muntafara sessilifolia with antiplasmodial and cytotoxic activities

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Cited by 25 publications
(26 citation statements)
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“…In the COSY spectrum, a multiplet corresponding to one proton at δ = 5.71 ppm is correlated with a doublet at δ = 1.80 ppm (CH 3 , J = 6.3 Hz), which suggests the presence of an ethylidene side‐chain. In addition, the downfield‐shifted proton at δ = 5.26 ppm, which correlates with the carbon at δ = 37.0 ppm in the HSQC spectrum, was assigned to 3‐H 4…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In the COSY spectrum, a multiplet corresponding to one proton at δ = 5.71 ppm is correlated with a doublet at δ = 1.80 ppm (CH 3 , J = 6.3 Hz), which suggests the presence of an ethylidene side‐chain. In addition, the downfield‐shifted proton at δ = 5.26 ppm, which correlates with the carbon at δ = 37.0 ppm in the HSQC spectrum, was assigned to 3‐H 4…”
Section: Resultsmentioning
confidence: 99%
“…In a previous report, indole alkaloids of the iboga, vobasinyl and apparicine types were identified and bisindole alkaloids were mentioned 3. We have also reported the isolation of tabernaelegantine derivatives from the EtOAc extract of the stem bark of Muntafara sessilifolia 4…”
Section: Introductionmentioning
confidence: 84%
“…9). 116 Investigation of the chemical constituents of the seeds of Strychnos nux-vomica resulted in the isolation of two new indole alkaloids, strynuxlines A (297) and B (298), featuring an unprecedented 6/5/ 9/6/7/6 hexacyclic ring system. Both compounds were assayed for their cytotoxicity against ve human cancer cell lines (Fig.…”
Section: Tryptaminesmentioning
confidence: 99%
“…52). 298 Four vobasinyl-iboga-type bisindole alkaloids, ervachinines A (950), B (951), C (952), and D (953), were isolated from the EtOH extract of the whole plant of Ervatamia chinensis, which is mainly found in the Yunnan and Guangxi provinces of China. All the compounds were evaluated for cytotoxicity against human cell lines.…”
Section: Bisindole Alkaloidsmentioning
confidence: 99%
“…Studies conducted by Ramalhete et al, 2008 revealed moderate or no significant activity of polar leaf extracts from the same plant species. Nevertheless, studies conducted on indole alkaloids from a closely related species, T. sessilifolia, showed some good antiplasmodial activity (Girardot et al, 2012), which could explain the observed bioactivity.…”
Section: Resultsmentioning
confidence: 97%