Indocyanine green anterior segment angiography for studying conjunctival vascular changes after trabeculectomy

Alsagoff, Zainah; Chew, Paul; Chee, Caroline; Wong, Jun‐Shyan; Aung, Tin

doi:10.1046/j.1442-9071.2001.00365.x

Cited by 15 publications

(7 citation statements)

References 2 publications

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“…In fact, angiogenesis is a central mechanism in the wound-healing process during the postoperative period after filtering surgery 11. Clinical,12,13 in vivo confocal microscopy (IVCM),7,14–16 and angiographic studies17,18 of conjunctival and episcleral vessels of filtering blebs have shown that highly vascularized blebs tend to be more frequently associated with surgical failure. Nevertheless, none of these imaging techniques provide a quantitative evaluation of the conjunctival vessels, and they require either contact with the eye (IVCM) or the injection of a dye (angiography).…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Angiography Evaluation of Conjunctival Vessels During Filtering Surgery

Hayek

Labbé

Brasnu

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose To evaluate the changes in conjunctival vascularization with optical coherence tomography angiography (OCT-A) before and after filtering surgery and to correlate these results with filtering surgery success. Methods We evaluated 20 blebs of 20 patients after a first-time trabeculectomy. Conjunctival vascularization was quantified using ImageJ software. Eyes were classified into two groups according to the preoperative conjunctival vessel density: hypovascularized conjunctiva (HypoV; 10 eyes) and hypervascularized conjunctiva (HyperV; 10 eyes). The density of intraepithelial microcysts (0 to 3) was also analyzed. Results There were significantly more needling procedures in the HyperV group, with 70% of the eyes undergoing needling during follow-up compared to 20% in the HypoV group ( P = 0.012). In the HyperV group, 50% of the eyes required IOP-lowering eyedrops after surgery, compared to 10% in the HypoV group ( P = 0.029). HypoV showed significantly more intraepithelial microcysts than did HyperV at 1 week (1.1 vs. 0.4, P = 0.0215), 1 month (2.2 vs. 0.4, P = 0.0003), and 6 months postoperatively (2.0 vs. 0.7, P = 0.0068). A statistically significant correlation was found between preoperative conjunctival vascular density and mean IOP at 1 week ( r = 0.483, P = 0.038), 1 month ( r = 0.714, P = 0.001), and 6 months postoperatively ( r = 0.471, P = 0.043). There was no statistically significant correlation between the preoperative conjunctival vascularization density and the eyedrop-year rate ( r = 0.036, P = 0.8704) or the preservative-year rate ( r = 0.1444, P = 0.5107). Conclusions Poor conjunctival vascularization was associated with lower IOP and a higher number of intraepithelial microcysts evaluated with OCT-A. OCT-A provides a simple, noninvasive, and reproducible method to analyze and quantify bleb vessels before and after filtering surgery. Translational Relevance Several studies have demonstrated that highly vascularized blebs might be associated with a higher risk of failure. OCT-A may provide a dye-free, noncontact method for monitoring conjunctival vascularization after filtering surgery.

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Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Angiography Evaluation of Conjunctival Vessels During Filtering Surgery

Hayek

Labbé

Brasnu

et al. 2019

Trans. Vis. Sci. Tech.

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“…[5][6][7]11 The ACA route is where a branch of the ACA extends from the posterior orbit to feed the rectal muscles and anterior segment of the eye. Also, some episcleral branches split from the penetrating branch fl ow together with the branches of ACA and run along the limbus to form perilimbal circulating arteries with anastomoses to other areas.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival vasculature patterns influencing the filtering bleb shape following trabeculectomy with limbal-based conjunctival flaps

et al. 2009

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“…Hence, our study was conducted in an effort to determine whether graft vascularization differs between 2 different graft fixation techniques. Indocyanine green angiography was shown to be useful in demonstrating anterior segment circulation after trabeculectomy and strabismus surgeries (21,22). Also, it was used to grade the intensity of ocular inflammation in scleritis (23).…”

Section: Discussionmentioning

confidence: 99%

Vascularization of Conjunctival Autografts in Pterygium Surgery: Comparison of Fibrin Glue with Sutures

Küçükerdönmez

Karalezlı

Zengin

et al. 2014

European Journal of Ophthalmology

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Indocyanine green anterior segment angiography for studying conjunctival vascular changes after trabeculectomy

Abstract: Angiography using ICG has potential as an investigative tool to study the conjunctival and episcleral vasculature changes after trabeculectomy.

Cited by 15 publications

References 2 publications

Optical Coherence Tomography Angiography Evaluation of Conjunctival Vessels During Filtering Surgery

Optical Coherence Tomography Angiography Evaluation of Conjunctival Vessels During Filtering Surgery

Conjunctival vasculature patterns influencing the filtering bleb shape following trabeculectomy with limbal-based conjunctival flaps

Vascularization of Conjunctival Autografts in Pterygium Surgery: Comparison of Fibrin Glue with Sutures

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