Indocyanine green and infrared fluorescence in detection of sentinel lymph nodes in endometrial and cervical cancer staging – a systematic review

Rocha, Ana; Domínguez, Ana María Rodríguez; Lécuru, Fabrice; Bourdel, Nicolas

doi:10.1016/j.ejogrb.2016.09.027

Cited by 57 publications

(36 citation statements)

References 30 publications

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“…It was notable that the sensitivity of ICG NIR flouresence varies according to the site of the primary malignancy. The sensitivity of ICG fluorescence ranges from 50% to 100% for endometrial and cervical carcinoma, 50‐100% for gastric cancer, 75% for esophageal carcinoma, whereas, the sensitivity in the cases of breast cancer varies from 95% to 100% with overall detection rates ranging between 88.6% and 100% …”

Section: Discussionmentioning

confidence: 99%

“…35,36 The concept of SLN was first described by Gould et al 37 39 whereas, the sensitivity in the cases of breast cancer varies from 95% to 100% 10 with overall detection rates ranging between 88.6% and 100%. 16 The present review included 12 studies that were conducted within a 10-year duration. The studies included a total of fewer than 250 patients reflecting their small sample size.…”

Section: Adverse Effects Of Icg Injectionmentioning

confidence: 99%

“…ICG NIR fluorescence is primarily employed in CRC for assessment of the perfusion of the bowel ends prior to the anastomosis . ICG NIR fluorescence for SLN detection has been previously described with promising results for breast, endometrial and cervical, gastric, and pancreatic carcinoma . ICG NIR fluorescence can potentially help improve the oncologic outcome of surgery by florescent SLN mapping.…”

Section: Introductionmentioning

confidence: 99%

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Sensitivity and specificity of indocyanine green near‐infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: Systematic review and meta‐analysis

Emile

Elfeki

Shalaby

et al. 2017

Journal of Surgical Oncology

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This review aimed to determine the overall sensitivity and specificity of indocyanine green (ICG) near-infrared (NIR) fluorescence in sentinel lymph node (SLN) detection in Colorectal cancer (CRC). A systematic search in electronic databases was conducted. Twelve studies including 248 patients were reviewed. The median sensitivity, specificity, and accuracy rates were 73.7, 100, and 75.7. The pooled sensitivity and specificity rates were 71% and 84.6%. In conclusion, ICG-NIR fluorescence is a promising technique for detecting SLNs in CRC.

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Section: Discussionmentioning

confidence: 99%

Section: Adverse Effects Of Icg Injectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sensitivity and specificity of indocyanine green near‐infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: Systematic review and meta‐analysis

Emile

Elfeki

Shalaby

et al. 2017

Journal of Surgical Oncology

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“…3. Cervical: The cervical injection is the modality most often reported in studies [23]. The technique is reproducible, because the uterine cervix is accessible and rarely distorted in patients with EC [24].…”

Section: Injection Techniquesmentioning

confidence: 99%

“…A single case of a severe allergic reaction after IV injection has been reported (incidence rate of 0.05%) [60]. However, the dye is contraindicated for use in patients with allergies to iodine [23,56]. Nevertheless, given that iodine is a chemical element and an essential component of the human body, a number of authors have suggested the safety of using ICG in patients with iodine allergies, given that a type I allergic reaction (antibody-mediated and responsible for anaphylactic shock) will not occur [36].…”

Section: Indocyanine Greenmentioning

confidence: 99%

Role of Sentinel Node Biopsy in Endometrial Cancer

Noval¹

2020

Current Cancer Treatment

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Lymphadenectomy, for early stages of endometrial cancer (EC), provides a low detection rate of lymphatic metastasis, without having demonstrated a therapeutic effect; so that the collection and histological analysis of the sentinel lymph node (SLN) might be an alternative to lymphadenectomy. The contribution of SLN to surgical staging represents a change in the paradigm of lymphadenectomy in EC, being an intermediate approach between not assessing the condition of the lymph nodes and complete pelvic and paraaortic dissection. Accurate identification of the main uterine drainage pathway increases the likelihood of detecting metastases during lymphatic mapping. In addition, pathological assessment by the ultrastaging of the SLN is the most important advance in the SLN biopsy (SLNB) technique. The application of the SLNB presumes a decrease in surgical and long-term morbidity, with an increase in the detection of lymphatic metastasis, mainly at the expense of detecting low tumour volume, selecting the group of patients that would benefit from a modification in adjuvant therapy. The SLNB can be established as an oncologically safe and effective method in the surgical staging of early-stage EC. Prospective studies are required to determine optimal behaviour and prognosis in the detection of low-volume metastases.Keywords: endometrial cancer, lymphatic mapping, predictive value of tests, sentinel lymph node biopsy, ultrastaging This information, provided by SLN, will change the therapeutic approach, with a potential benefit in the prognosis, both in survival and quality of life [6]. Detection methodTheoretically, the ideal method for studying SLN in EC should meet the following requirements:1. Cause the least amount of patient discomfort possible, be easy to perform and be reproducible.2. Be a preoperative procedure that enables planning of the surgical approach according to the anatomical location of the SLN.3. Enable a laparoscopic approach according to the concept of minimally invasive surgery.4. Enable the detection of SLN without complete dissection of the retroperitoneal space.5. Obtain a lymphatic map representative of the tumour drainage or, at least, of the uterine body drainage [7]. Lymphatic drainage of the uterusUnlike superficial tumours, such as melanoma, the physiology of lymphatic drainage in deeper/visceral tumours is not well established [8]. Uterine drainage, as well as being bilateral, is therefore complex [9]. Anatomically, three segments of uterine lymphatic drainage have been established:1. The lower uterine segment drains from the paracervix to the parametrium and to the broad ligament, passing by the obturator, internal iliac and interiliac lymph node chains.2. The middle third of the uterus drains the round ligament and the external iliac lymph node chain.3. The upper uterine segment drains through the infundibular pelvic ligament, uterine-ovarian plexus and gonadal vessels towards the common iliac lymph node chain, presacral lymph nodes and paraaortic lymph nodes [10].Physiologically, there a...

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Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer

Nagar

Wietek

Goodall

et al. 2021

Cochrane Database of Systematic Reviews

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Indocyanine green and infrared fluorescence in detection of sentinel lymph nodes in endometrial and cervical cancer staging – a systematic review

Cited by 57 publications

References 30 publications

Sensitivity and specificity of indocyanine green near‐infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: Systematic review and meta‐analysis

Sensitivity and specificity of indocyanine green near‐infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: Systematic review and meta‐analysis

Role of Sentinel Node Biopsy in Endometrial Cancer

Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer

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