Sensitivity and specificity of indocyanine green near‐infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: Systematic review and meta‐analysis

Emile, Sameh Hany; Elfeki, Hossam; Shalaby, Mostafa; Sakr, Ahmad; Sileri, Pierpaolo; Laurberg, Søren; Wexner, Steven D.

doi:10.1002/jso.24701

Cited by 78 publications

(37 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This rate of identification was similar to published results of 89% to 98% detection, with a false negative rate of 18-67% [31]. A recent systematic review of 12 studies including 248 patients reported pooled sensitivity and specificity rates were 71% and 84.6%, with median sensitivity, specificity, and accuracy rates of 73.7, 100, and 75.7% [32]. However the review included both colon and rectal cancer, and demonstrated the heterogeneity in reported data.…”

Section: Ten Consecutive Patients With a Diagnosis Of Colon Cancer Unsupporting

confidence: 84%

Feasibility of fluorescence lymph node imaging in colon cancer: FLICC

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Ten Consecutive Patients With a Diagnosis Of Colon Cancer Unsupporting

confidence: 84%

Feasibility of fluorescence lymph node imaging in colon cancer: FLICC

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Moreover, similar to other malignancies, synchronous intracervical and intrauterine injection might also be considered. For colorectal cancer, some authors have proposed synchronous submucosal and subserosal injection with encouraging results (19). According to a meta-analysis by Emile, the submucosal and subserosal injection of indocyanine green in association with preoperative injection is correlated with a significantly higher rate of sentinel node detection (19).…”

Section: Discussionmentioning

confidence: 99%

Indocyanine green utility in sentinel node detection for cervical cancer patients

Bacalbaşa¹,

Bălescu²,

Bălălău³

et al. 2019

JMMS

View full text Add to dashboard Cite

With wide implementation of screening tests for the Human Papilloma Virus, the number of diagnosed cases of premalignant or early stages of cervical cancer has increased considerably. As a consequence, surgeons' attention has focused on determining how best to limit the surgical procedure so the benefits of the procedure will not be surpassed by postoperative morbidity. In this respect, extended lymph node dissection, routinely associated so far with cervical cancer patients, has in the last decades been replaced with sentinel node detection and biopsy. Initially performed through radiocolloid injection, this method has undergone permanent changes in order to maximize its efficacy and safety. Although the laparoscopic approach had been widely used in the past, a new method has been proposed, i.e., the use of indocyanine green injection, which has yielded promising results for sentinel node detection in the early stages of cervical carcinoma. This paper reviews the literature of the most relevant studies conducted on this topic.

show abstract

“…Sentinel lymph node techniques have demonstrated relatively low sensitivity and specificity for determining lymph node involvement in colorectal cancer 46 and radiocolloid injection techniques have been particularly disappointing in rectal cancer 47 . Indocyanine green (ICG) near-infrared fluorescence imaging has shown potential for lymph node mapping in colorectal cancer, with sensitivities and specificities of 70-85 per cent 48 . Few data exist to support its use in the context of pelvic sidewall involvement of rectal cancer, but one small study 49 of 42 patients with mid-to-low rectal cancers found improved lymph node yield and reduced risk of incomplete LPND with concomitant use of ICG.…”

Section: Directions For Future Researchmentioning

confidence: 99%

Rectal cancer lateral pelvic sidewall lymph nodes: a review of controversies and management

Williamson

Quyn

Sagar

2020

British Journal of Surgery

View full text Add to dashboard Cite

Background: The management of lateral pelvic lymphadenopathy in low rectal cancer poses an oncological and technical challenge. Interpretation of the literature is confounded by different approaches to management in the East and West, and a lack of randomized data from which to draw accurate conclusions regarding the optimal approach. Recent collaboration between Eastern and Western centres has increased the standardization of care. Despite this, significant differences in international guidelines remain. The aim of this review was to appraise the available literature and propose a management algorithm. Methods: A literature review of all relevant studies was performed to summarize the historical evidence, as well as establish the significance of clinically positive lateral pelvic sidewall nodes, and the role of neoadjuvant chemoradiotherapy and lateral pelvic node dissection. A management algorithm was developed based on this review of the literature. Results: The management of pelvic sidewall lymphadenopathy in rectal cancer is non-standardized, with geographical differences. The mechanism of lateral lymphatic spread is well defined; the risk increases with lower tumour height and advanced T category. Existing data indicate that acceptable disease-free and overall survival can be achieved by neoadjuvant chemoradiotherapy with selective lateral pelvic node dissection. Conclusion: Suspicious lateral pelvic sidewall nodes, particularly in the internal iliac chain, should be considered as resectable locoregional disease, and surgery offered for enlarged nodes that do not respond to neoadjuvant chemoradiotherapy.

show abstract

Sensitivity and specificity of indocyanine green near‐infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: Systematic review and meta‐analysis

Cited by 78 publications

References 40 publications

Feasibility of fluorescence lymph node imaging in colon cancer: FLICC

Feasibility of fluorescence lymph node imaging in colon cancer: FLICC

Indocyanine green utility in sentinel node detection for cervical cancer patients

Rectal cancer lateral pelvic sidewall lymph nodes: a review of controversies and management

Contact Info

Product

Resources

About