Individually tuned theta HD-tACS improves spatial performance

Zhang, Da-Wei; Moraidis, Alexandros; Klingberg, Torkel

doi:10.1016/j.brs.2022.10.009

Cited by 12 publications

(16 citation statements)

References 55 publications

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“…There are also reports of null and state-dependent effects of frontal lobe stimulation on arithmetic performance. Left PFC anodal tDCS or alpha tACS did not affect learning novel arithmetic procedures and facts ( Mosbacher et al, 2021 ), while concurrent right MFG and left IPS individually tuned HD theta tACS did not improve one-digit addition and two-digit subtraction task performance ( Zhang et al, 2022 ). Interestingly, bilateral PFC full-spectrum tRNS failed to enhance the performance of a calculation prodigy in a complex multiplication task and reduced task accuracy of postgraduate students with highly standardized mathematics scores in simplified multiplication problems, indicating ineffective or deleterious effects for individuals with already high-performing arithmetic functioning ( Krause et al, 2019 ).…”

Section: Resultsmentioning

confidence: 95%

“…TES effects are limited not only to cortical areas beneath the electrodes but also to areas affected by the electric field generated between them, even reaching deep regions ( Bikson et al, 2010 ; Garcia-Sanz et al, 2022 ). Out of all the analyzed tES studies, only seven conducted electric field distribution simulations ( Klein et al, 2013a , b ; Artemenko et al, 2015 ; Grabner et al, 2015 ; Hauser et al, 2016 ; Luft et al, 2017 ; Bieck et al, 2018 ; Zhang et al, 2022 ). This means that in the remaining studies, the target areas may not be adequately reached and optimally stimulated, specifically during IPS stimulation, where the depth of current penetration is critical.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

Fresnoza,

Ischebeck

2024

eNeuro

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This systematic review presented a comprehensive survey of studies that applied transcranial magnetic stimulation and transcranial electrical stimulation to parietal and nonparietal areas to examine the neural basis of symbolic arithmetic processing. All findings were compiled with regard to the three assumptions of the triple-code model (TCM) of number processing. Thirty-seven eligible manuscripts were identified for review (33 with healthy participants and 4 with patients). Their results are broadly consistent with the first assumption of the TCM that intraparietal sulcus both hold a magnitude code and engage in operations requiring numerical manipulations such as subtraction. However, largely heterogeneous results conflicted with the second assumption of the TCM that the left angular gyrus subserves arithmetic fact retrieval, such as the retrieval of rote-learned multiplication results. Support is also limited for the third assumption of the TCM, namely, that the posterior superior parietal lobule engages in spatial operations on the mental number line. Furthermore, results from the stimulation of brain areas outside of those postulated by the TCM show that the bilateral supramarginal gyrus is involved in online calculation and retrieval, the left temporal cortex in retrieval, and the bilateral dorsolateral prefrontal cortex and cerebellum in online calculation of cognitively demanding arithmetic problems. The overall results indicate that multiple cortical areas subserve arithmetic skills.

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

Fresnoza,

Ischebeck

2024

eNeuro

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“…An illustrative result, in this case, is the significant cognitive improvement found in age-related working memory deficits after “forcing” the coupling between brain regions using high-density transcranial alternating current stimulation (HD-tACS) ES. The dual-site HD-tACS was effective not only in reversing age-related cognitive deficits but also improved spatial task performance in adult human subjects ( Zhang et al, 2022 ). In other words, by “grossly” stimulating two different brain areas using a non-invasive procedure, Reinhart and Nguyen were able to frequency tune theta wave synchronization along the frontoparietal cortex ( Reinhart and Nguyen, 2019 ; Reinhart, 2022 ).…”

Section: Nps Meets the Coincidence-detection Framework: Driving The I...mentioning

confidence: 99%

On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain’s functional connectogram

Cota

Cançado

Moraes

2023

Front. Neuroinform.

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Rationalized development of electrical stimulation (ES) therapy is of paramount importance. Not only it will foster new techniques and technologies with increased levels of safety, efficacy, and efficiency, but it will also facilitate the translation from basic research to clinical practice. For such endeavor, design of new technologies must dialogue with state-of-the-art neuroscientific knowledge. By its turn, neuroscience is transitioning—a movement started a couple of decades earlier—into adopting a new conceptual framework for brain architecture, in which time and thus temporal patterns plays a central role in the neuronal representation of sampled data from the world. This article discusses how neuroscience has evolved to understand the importance of brain rhythms in the overall functional architecture of the nervous system and, consequently, that neuromodulation research should embrace this new conceptual framework. Based on such support, we revisit the literature on standard (fixed-frequency pulsatile stimuli) and mostly non-standard patterns of ES to put forward our own rationale on how temporally complex stimulation schemes may impact neuromodulation strategies. We then proceed to present a low frequency, on average (thus low energy), scale-free temporally randomized ES pattern for the treatment of experimental epilepsy, devised by our group and termed NPS (Non-periodic Stimulation). The approach has been shown to have robust anticonvulsant effects in different animal models of acute and chronic seizures (displaying dysfunctional hyperexcitable tissue), while also preserving neural function. In our understanding, accumulated mechanistic evidence suggests such a beneficial mechanism of action may be due to the natural-like characteristic of a scale-free temporal pattern that may robustly compete with aberrant epileptiform activity for the recruitment of neural circuits. Delivering temporally patterned or random stimuli within specific phases of the underlying oscillations (i.e., those involved in the communication within and across brain regions) could both potentiate and disrupt the formation of neuronal assemblies with random probability. The usage of infinite improbability drive here is obviously a reference to the “The Hitchhiker’s Guide to the Galaxy” comedy science fiction classic, written by Douglas Adams. The parallel is that dynamically driving brain functional connectogram, through neuromodulation, in a manner that would not favor any specific neuronal assembly and/or circuit, could re-stabilize a system that is transitioning to fall under the control of a single attractor. We conclude by discussing future avenues of investigation and their potentially disruptive impact on neurotechnology, with a particular interest in NPS implications in neural plasticity, motor rehabilitation, and its potential for clinical translation.

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“…The largest number of tACS studies (e.g., Jaušovec and Jaušovec, 2014 ; Jaušovec et al, 2014 ; Meiron and Lavidor, 2014 ; Vosskuhl et al, 2015 ; Alekseichuk et al, 2016 , 2017 ; Feurra et al, 2016 ; Santarnecchi et al, 2016 ; Kleinert et al, 2017 ; Borghini et al, 2018 ; Pahor and Jaušovec, 2018 ; Röhner et al, 2018 ; Tseng et al, 2018 ; Wolinski et al, 2018 ; Bender et al, 2019 ; Jones et al, 2019 ; Reinhart and Nguyen, 2019 ; Abellaneda-Pérez et al, 2020 ; Guo et al, 2021 ; Hosseinian et al, 2021 ; Sahu and Tseng, 2021 ; Biel et al, 2022 ; Draaisma et al, 2022 ; Hu et al, 2022 ; Soutschek et al, 2022 ; Zeng et al, 2022 ; Zhang et al, 2022 ; Grover et al, 2023 ; Rauh et al, 2023 ; Yang et al, 2023 ) targeted the theta band (4 Hz−7 Hz), which was proposed as the brain rhythm most strongly involved in encoding and maintaining the item sequences in WM (e.g., Lisman and Idiart, 1995 ; Jacob et al, 2018 ; Sauseng et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…A corresponding improvement for the forward and backward recall tasks was replicated by Vosskuhl et al ( 2015 ) as a result of stimulating at individual theta frequency minus 1 Hz (i.e., presumably slowing down a key theta rhythm). Zhang et al ( 2022 ) observed no increase for the visuospatial forward recall task when slowing the theta down, but noted an increase when tuning stimulation precisely to individual theta frequency (at around 6 Hz). Null effects were reported also by Feurra et al ( 2016 ) for 5-Hz tACS.…”

Section: Introductionmentioning

confidence: 99%

No effects of the theta-frequency transcranial electrical stimulation for recall, attention control, and relation integration in working memory

Ociepka,

Chinta,

Basoń

et al. 2024

Front. Hum. Neurosci.

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IntroductionRecent studies have suggested that transcranial alternating current stimulation (tACS), and especially the theta-frequency tACS, can improve human performance on working memory tasks. However, evidence to date is mixed. Moreover, the two WM tasks applied most frequently, namely the n-back and change-detection tasks, might not constitute canonical measures of WM capacity.MethodIn a relatively large sample of young healthy participants (N = 62), we administered a more canonical WM task that required stimuli recall, as well as we applied two WM tasks tapping into other key WM functions: attention control (the antisaccade task) and relational integration (the graph mapping task). The participants performed these three tasks three times: during the left frontal 5.5-Hz and the left parietal 5.5-Hz tACS session as well as during the sham session, with a random order of sessions. Attentional vigilance and subjective experience were monitored.ResultsFor each task administered, we observed significant gains in accuracy neither for the frontal tACS session nor for the parietal tACS session, as compared to the sham session. By contrast, the scores on each task positively inter-correlated across the three sessions.DiscussionThe results suggest that canonical measures of WM capacity are strongly stable in time and hardly affected by theta-frequency tACS. Either the tACS effects observed in the n-back and change detection tasks do not generalize onto other WM tasks, or the tACS method has limited effectiveness with regard to WM, and might require further methodological advancements.

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Individually tuned theta HD-tACS improves spatial performance

Cited by 12 publications

References 55 publications

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

Probing Our Built-in Calculator: A Systematic Narrative Review of Noninvasive Brain Stimulation Studies on Arithmetic Operation-Related Brain Areas

On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain’s functional connectogram

No effects of the theta-frequency transcranial electrical stimulation for recall, attention control, and relation integration in working memory

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