Individualized Metabolic Surgery Score

Aminian, Ali; Brethauer, Stacy A.; Andalib, Amin; Nowacki, Amy S.; Jiménez, Amanda; Corcelles, Ricard; Hanipah, Zubaidah Nor; Punchai, Suriya; Bhatt, Deepak L.; Kashyap, Sangeeta R.; Burguera, Bartolomé; Lacy, Antonio M.; Vidal, Josep; Schauer, Philip R.

doi:10.1097/sla.0000000000002407

Cited by 218 publications

(92 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aminian et al38 devised the individualized metabolic surgery (IMS) scoring system to guide procedure selection based on long-term (>5 years) glucose control in patients with T2DM. They retrospectively collected data from 659 T2DM patients who underwent RYGB or SG at a single center in the United States and had completely documented glycemic follow-up for at least 5 years after surgery.…”

Section: Prediction Models Of Diabetes Remissionmentioning

confidence: 99%

See 1 more Smart Citation

Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery

Park

2018

JOMES

View full text Add to dashboard Cite

Bariatric surgery has evolved from a surgical measure for treating morbid obesity to an epochal remedy for treating metabolic syndrome as a whole, which is represented by type 2 diabetes mellitus. Numerous clinical trials have advocated bariatric or metabolic surgery over nonsurgical interventions because of markedly superior metabolic outcomes in morbidly obese patients who satisfy traditional criteria for bariatric surgery (body mass index [BMI] >35 kg/m 2 ) and in less obese or simply overweight patients. Nevertheless, not all diabetes patients achieve the most desirable outcomes; i.e., diabetes remission after metabolic surgery. Thus, candidates for metabolic surgery should be carefully selected based on comprehensive preoperative assessments of the risk-benefit ratio. Predictors for diabetes remission after metabolic surgery may be classified into two groups based on mechanism of action. The first is indices for preserved pancreatic beta-cell function, including younger age, shorter duration of diabetes, and higher C-peptide level. The second is the potential for an insulin resistance reduction, including higher baseline BMI and visceral fat area. Several prediction models for diabetes remission have been suggested by merging these two to guide the joint decision-making process between clinicians and patients. Three such models, DiaRem, ABCD, and individualized metabolic surgery scores, provide an intuitive scoring system and have been validated in an independent external cohort and can be utilized in routine clinical practice. These prediction models need further validation in various ethnicities to ensure universal applicability.

show abstract

Section: Prediction Models Of Diabetes Remissionmentioning

confidence: 99%

“…Preop, preoperative; HbA1c, glycosylated hemoglobin; RYGB, Roux-en-Y gastric bypass; SG, sleeve gastrectomy. Adapted from Aminian A, et al Ann Surg 2017;266:650–7, with permission from Wolters Kluwer Health Inc 38…”

Section: Figurementioning

confidence: 99%

Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery

Park

2018

JOMES

View full text Add to dashboard Cite

show abstract

“…Recently, bariatric surgery is endorsed as a treatment for obese diabetic patients by the International Diabetes Federation, American Diabetes Association (ADA), and American College of Surgeons [23]. However, T2DM remission rates appear to differ between surgery procedures, where RYGB has higher rates compared to SG and Gastric Band [4,24]. A study reported 60.2% of RYGB patients achieved diabetes remission after 7 years of surgery, compared to 20.3% for Gastric Banding [4].…”

Section: Introductionmentioning

confidence: 99%

“…A study reported 60.2% of RYGB patients achieved diabetes remission after 7 years of surgery, compared to 20.3% for Gastric Banding [4]. Long-term diabetes remission for SG was quite low in two studies: 35.3% for Taiwanese patients and 28% for American patients after 5 years of surgery [13,24], but another study reported a remission rate of 66% five years after SG [25].…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of Differential miRNA Expression after Bariatric Surgery

Langi

Szczerbiński

Krętowski

2019

JCM

View full text Add to dashboard Cite

Bariatric surgery is an efficient treatment for weight loss in obese patients and for resolving obesity comorbidities. However, the mechanisms behind these outcomes are unclear. Recent studies have indicated significant alterations in the transcriptome after surgery, specifically in the differential expression of microRNAs. In order to summarize the recent findings, we conducted a systematic summary of studies comparing microRNA expression levels before and after surgery. We identified 17 animal model and human studies from four databases (Ovid, Scopus, Web of Science, and PubMed) to be enrolled in this meta-analysis. From these studies, we identified 14 miRNAs which had the same direction of modulation of their expression after surgery in at least two studies (downregulated: hsa-miR-93-5p, hsa-miR-106b-5p, hsa-let-7b-5p, hsa-let-7i-5p, hsa-miR-16-5p, hsa-miR-19b-3p, hsa-miR-92a-3p, hsa-miR-222-3p, hsa-miR-142-3p, hsa-miR-140-5p, hsa-miR-155-5p, rno-miR-320-3p; upregulated: hsa-miR-7-5p, hsa-miR-320c). Pathway analysis for these miRNAs was done using database resources (DIANA-TarBase and KEGG pathway database) and their predicted target genes were discussed in relation with obesity and its comorbidities. Discrepancies in study design, such as miRNA source, bariatric surgery type, time of observation after surgery, and miRNA profiling methods, were also discussed.

show abstract

“…It should be noted that the SOS study contains a high proportion of patients with screen-detected T2D, resulting in a low average T2D duration, which may explain why addition of T2D duration to the 2-year weight change model did not increase the discriminatory capacity. However, the difference in T2D duration in non-relapse (00.4 and 0.3 years, respectively) and relapse (1.1 and 0.9 years, respectively) groups at 10 and 15 years confirms the importance of early surgical intervention for long-term glycemic control [ 2 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Prediction Models for Type 2 Diabetes Relapse After Post-bariatric Surgery Remission: a Post hoc Analysis of 15-Year Follow-up Data from the Swedish Obese Subjects (SOS) Study

et al. 2020

View full text Add to dashboard Cite

Purpose Many patients achieve type 2 diabetes (T2D) remission after bariatric surgery, but relapse after post-surgery remission is common. Scoring models accurately predict remission up to 5 years after surgery but have not been tested for prediction of longterm T2D relapse. The aim of this work was to test the ability of prediction models and single predictors to identify patients at risk of long-term relapse (10-15 years) after post-surgery T2D remission. Methods We identified 222 individuals with T2D from the surgically treated group in the prospective Swedish Obese Subjects study, who were in remission at the 2-year follow-up and had data available for prediction of long-term T2D relapse. T2D remission/relapse was assessed after 10 and 15 years. Model performance (discrimination) was evaluated by the area under the receiver operating characteristic (AUROC) curves. Results Preoperative prediction of relapse using scores DiaRem, Ad-DiaRem, and DiaBetter and T2D duration alone was poor, as indicated by AUROC curves between 0.61-0.64 at 10 years and 0.62-0.66 at 15 years. Likewise, the 5y-Ad-DiaRem score, which includes early postoperative measures, resulted in AUROC curves of 0.65 and 0.70 for relapse at 10 and 15 years, respectively. Two-year weight change alone had higher discriminatory capacity than the 5y-Ad-DiaRem model at 10 years (AUROC = 0.70; p = 0.036) and similar capacity at 15 years (AUROC = 0.78; p = 0.188). Conclusions Predictive performance of all tested models is low for T2D relapse. By contrast, a single measure of 2-year weight change after surgery was associated with relapse, supporting a key role for initial weight reduction in long-term T2D control.

show abstract

Individualized Metabolic Surgery Score

Abstract: This is the largest reported cohort (n = 900) with long-term postoperative glycemic follow-up, which, for the first time, categorizes T2DM into 3 validated severity stages for evidence-based procedure selection.

Cited by 218 publications

References 36 publications

Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery

Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery

Meta-Analysis of Differential miRNA Expression after Bariatric Surgery

Evaluation of Prediction Models for Type 2 Diabetes Relapse After Post-bariatric Surgery Remission: a Post hoc Analysis of 15-Year Follow-up Data from the Swedish Obese Subjects (SOS) Study

Contact Info

Product

Resources

About