Individualized Comprehensive Lifestyle Intervention in Patients Undergoing Chemotherapy with Curative or Palliative Intent: Who Participates?

Abstract

ObjectiveKnowledge about determinants of participation in lifestyle interventions in cancer patients undergoing chemotherapy, particularly with palliative intent, remains poor. The objective of the present study was to identify determinants of participating in a 12 month individualized, comprehensive lifestyle intervention, focusing on diet, physical activity, mental stress and smoking cessation, in cancer patients receiving chemotherapy with curative or palliative intent. The secondary objective was to identify participation determinants 4 months into the study.MethodsNewly diagnosed cancer patients starting chemotherapy at the cancer center in Kristiansand/Norway (during a 16 month inclusion period) were screened. Demographic and medical data (age, sex, body mass index, education level, marital status, smoking status, Eastern Cooperative Oncology Group performance status (ECOG), diagnosis, tumor stage and treatment intention) was analyzed for screened patients.Results100 of 161 invited patients participated. There were more females (69 vs. 48%; P = 0.004), breast cancer patients (46 vs. 25%; P = 0.007), non-smokers (87 vs. 74%; P = 0.041), younger (mean age 60 vs. 67 yrs; P < 0.001) and fitter (82 vs. 64% with EGOC 0; P = 0.036) participants vs. non-participants included. In multivariate logistic regression analyses, age (Odds Ratio 0.94, 95% Confidence Interval 0.91, 0.97) and smoking (0.42, 0.18, 0.99) were negatively associated with participation. After 4 months, 63 participants were still participating. Cancer type, smoking and age increased the probability of dropping out. Multivariate logistic regression revealed that age was the only significant determinant of 4 month participation (0.95, 0.91, 0.99). Patients aged >70 years were less likely to participate at baseline and 4 months.ConclusionIndividualized lifestyle interventions in cancer patients undergoing chemotherapy appear to facilitate a high participation rate that declines with increasing age; both during the enrollment process and completing the intervention. Neither oncologic nor socioeconomic variables deterred participation.

Synergic Effect of α‐Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model

“…Over recent years in Mexico and around the world, there has been an increase in cancer research and a greater focus on new therapeutic strategies and detection methods [29]. It has been reported that a therapeutic and preventive effect can be achieved for several types of cancer with phytochemical derivatives of food or food sources, like capsaicin (peppers) [30], curcumin (curcuma) [31], resveratrol (grapes) [32], lycopene (tomatoes) [33], cinnamon essential oil [34], and others [35].…”

Adverse Health Outcomes Associated with Postdiagnosis Smoking in Prostate Cancer Patients: A Literature Review

“…Unfortunately, many studies testing the effectiveness of interventions are threatened by high dropout rates, low adherence, and inaccuracy of self-reported tobacco use [75][76][77]. Furthermore, smoking is negatively associated with participation in lifestyle interventions [75]. These results illustrate the unique difficulties that health care professionals may face in terms of encouraging healthier behaviors in this population.…”

Lifestyle changes in cancer patients undergoing curative or palliative chemotherapy: is it feasible?

“…I CAN aims to increase adherence to healthy lifestyle behaviors, based on participants preferences and barriers, including a healthy diet [21], PA [2], stress management [22] and smoking cessation [23]. The intervention is described in detail previously [24].…”

“…Assessment of medical and demographic variables is described in detail previously [24]. Tumor type was categorized into breast; colorectal ; prostate; and other cancer types (gastric, pancreas, gallbladder, urinary bladder, hepatic and origo incerta), respectively.…”

“…Exclusion criteria were suspected anorexia cachexia syndrome and severe mental disorder (evaluated by the patients primary physician). The detailed inclusion process is described previously [24].…”