Lifestyle changes in cancer patients undergoing curative or palliative chemotherapy: is it feasible?

Vassbakk-Brovold, Karianne; Berntsen, Sveinung; Fegran, Liv; Lian, Henrik; Mjåland, Odd; Mjåland, Svein; Nordin, Karin; Seiler, Stephen; Kersten, Christian

doi:10.1080/0284186x.2017.1413247

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Lifestyle changes during active oncology treatment, especially chemotherapy, should be initiated early and not pushed off to ''after the treatment.'' 31 This study has a number of limitations that need to be addressed in future research. First, the assessment of physical activity was based on self-reported information, with patients being considered to be physically active if they fulfilled at least one of the four criteria specified in the ACS guidelines.…”

Section: Physical Activity and Use Of Complementary Medicinementioning

confidence: 96%

Association Between Physical Activity and Use of Complementary Medicine by Female Oncology Patients in an Integrative Palliative Care Setting

Raz

Samuels

Levy

et al. 2020

The Journal of Alternative and Complementary Medicine

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Objective: To examine the association between physical activity and the reported use of complementary medicine by patients with breast and gynecological cancer referred or self-referred to a complementary/ integrative medicine (CIM) consultation within a palliative care context.Methods: Retrospective observational study analyzing the medical files of patients referred to a CIM consultation provided within a specialized integrative oncology clinic for demographic and cancer-related parameters; participation in physical exercise and activities; and current use of nonconventional medical practices. Quality of life (QoL) outcomes were assessed during the initial CIM consultation by using the Edmonton Symptom Assessment Scale (ESAS) tool.Results: Among the 162 patient files examined, participation in physical activities was reported in 152, of whom 83 were identified as active and 69 inactive according to the American Cancer Society guidelines. A logistic multivariate regression model showed that physical activity was associated with higher rates of herbal/dietary supplement use for noncancer-related outcomes (odds ratio = 7.21, 95% confidence interval [CI] 1.6-32.46, p = 0.01); more frequently reported use of acupuncture for cancer-related outcomes (odds ratio = 7.79, 95% CI 1.93-31.5, p = 0.004); and lower ESAS scores for well-being (odds ratio = 0.77, 95% CI 1.0.65-0.92, p = 0.004), indicating better QoL.Conclusion: Physical activity was found to be associated with a greater use of CIM (specifically herbal/ dietary supplement use and acupuncture) in patients with breast and gynecological cancer during oncology treatment. Further research is needed to explore whether CIM use and physical activity are influenced by patients' health-belief models of care, and whether the CIM consultation can promote physical activity among these patients.

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Section: Physical Activity and Use Of Complementary Medicinementioning

confidence: 96%

Association Between Physical Activity and Use of Complementary Medicine by Female Oncology Patients in an Integrative Palliative Care Setting

Raz

Samuels

Levy

et al. 2020

The Journal of Alternative and Complementary Medicine

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“…Despite the overrepresentation of patients with breast cancer, the distribution between the different cancer therapies (chemotherapy, radiotherapy and endocrine therapy) was evenly distributed, with around 30% in each treatment group. Our sample consists of patients who are sufficiently fit to participate in such a study, and might be more active than the average patient group resulting in higherV O 2 max values [45]. However, in case of such a bias, real PA and CRF in the overall population of patients with cancer may be even lower than in our study.…”

Section: Discussionmentioning

confidence: 81%

The Phys-Can observational study: adjuvant chemotherapy is associated with a reduction whereas physical activity level before start of treatment is associated with maintenance of maximal oxygen uptake in patients with cancer

Wiestad

Raastad

Nordin

et al. 2020

BMC Sports Sci Med Rehabil

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Background: Adjuvant therapy may cause multiple sideeffects on long term health, including reduced cardiorespiratory fitness (CRF) in patients with breast cancer (1, 2). However, there is currently limited knowledge regarding the effect of different types of adjuvant cancer treatment on CRF in other cancer populations. The primary objective of the present study was to assess whether previously known correlates (age, diagnosis, initial CRF, physical activity level), type of adjuvant treatment and cancer-related fatigue were associated with changes iṅ VO 2 max in patients with breast, prostate or colorectal cancer. Methods: Prospective study with two time points of assessment, 85 patients scheduled for adjuvant cancer treatment were included. Cardiorespiratory fitness was assessed by˙VO 2 max during a maximal incremental exercise test on a treadmill before start of adjuvant therapy and again six months later. Physical activity level was recorded with a physical activity monitor (Sense Wear™ Mini) at baseline as average minutes of moderate-to-vigorous intensity physical activity (MVPA) per day. Physical fatigue at baseline was reported using the Multidimensional Fatigue Inventory-20 questionaire. Results: In multivariate linear regression analysis, 30 min higher daily MVPA at baseline was associated with a 5% higherVO 2 max at six months follow up when adjusted for adjuvant treatment (P = 0.010). Patients receiving adjuvant chemotherapy had a mean decline inVO 2 max of 10% (− 19, − 1; 95% confidence interval) compared to patients receiving adjuvant endocrine treatment (P = 0.028). Adjuvant radiotherapy, fatigue, age and diagnosis were not significantly associated with changes inVO 2 max.

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“…Dropouts were associated with older age, certain diagnoses, and smoking status. A significant dietary habits, distress levels, and physical activity improvements was recorded by the finding as well as the feasibility and potential benefits of a comprehensive lifestyle intervention for cancer patients undergoing chemotherapy including those in palliative care [ 52 ]. In addition, Godsey et al explored the potential synergy between herbal supplements and conventional treatments.…”

Section: Oxidative Stress and Antioxidant Mechanism In Oral Cancer Re...mentioning

confidence: 99%

Oxidative Stress in the Pathogenesis of Oral Cancer

Ionescu,

Kamal,

Ciobica

et al. 2024

Biomedicines

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Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) and antioxidants, contributes significantly to oral cancer such as oral squamous cell carcinoma (OSCC) initiation, promotion, and progression. ROS, generated both internally and externally, induce cellular damage including DNA mutations and lipid peroxidation, fostering oncogene activation and carcinogenesis. The objective of this review was to cover and analyze the interplay between ROS and antioxidants, influencing the key processes such as cell proliferation, apoptosis, and angiogenesis, shaping the trajectory of OSCC development. Despite the promise of antioxidants to halt cancer progression and mitigate oxidative damage, their therapeutic efficacy remains debated. The conducted literature search highlighted potential biomarkers that indicate levels of oxidative stress, showing promise for the early detection and monitoring of OSCC. Furthermore, melatonin has emerged as a promising adjunct therapy for OSCC, exerting antioxidant and oncostatic effects by modulating tumor-associated neutrophils and inhibiting cancer cell survival and migration. In addition, this review aims to shed light on developing personalized therapeutic strategies for patients with OSCC such as melatonin therapy, which will be discussed. Research is needed to elucidate the underlying mechanisms and clinical implications of oxidative stress modulation in the context of oral cancer.

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Lifestyle changes in cancer patients undergoing curative or palliative chemotherapy: is it feasible?

Cited by 5 publications

References 37 publications

Association Between Physical Activity and Use of Complementary Medicine by Female Oncology Patients in an Integrative Palliative Care Setting

Association Between Physical Activity and Use of Complementary Medicine by Female Oncology Patients in an Integrative Palliative Care Setting

The Phys-Can observational study: adjuvant chemotherapy is associated with a reduction whereas physical activity level before start of treatment is associated with maintenance of maximal oxygen uptake in patients with cancer

Oxidative Stress in the Pathogenesis of Oral Cancer

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