Individual ovarian volumes obtained from 2-dimensional and 3-dimensional ultrasound lack precision

Brett, Sandra; Bee, Natalie; Wallace, W. Hamish B.; Rajkhowa, Madhurima; Kelsey, Tom

doi:10.1016/s1472-6483(10)60092-2

Cited by 18 publications

(13 citation statements)

References 27 publications

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“…This finding is compatible with that reported by Brett et al , who demonstrated a lack of precision in ovarian volume measurement by 2D and 3D ultrasound, which overestimate ovarian volumes [22]. The authors advise that the possibility of error should be taken into account when making clinical decisions.…”

Section: Discussionsupporting

confidence: 91%

Adequacy of ovarian diathermy under ultrasound control: an experimental model

et al. 2013

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BackgroundTo develop a minimally invasive ovarian cauterization technique under transvaginal ultrasound control and evaluate the safety and feasability of monopolar cauterization to cause ovarian injury using female cattle of reproductive age as an experimental model.MethodExperimental study in a university research center was performed. Eleven female bovines of reproductive age were submitted to monopolar transvaginal ovarian cauterization. The right ovary (RO) was punctured at four sites and 40 W was applied for 5 s at each point, resulting in a total of 800 J (Joules) of thermal energy. In the left ovary (LO), the procedure was similar, with the same time and 80 W, resulting in a thermal energy of 1600 J. Macroscopic and microscopic lesions were assessed.ResultsOf 22 ovaries punctured, 20 were cauterized and exhibited macroscopic and typical microscopic lesions. No lesions could be found in the needle path. The measures of the areas of microscopic electrocautery lesions calculated estimating a cylindrical volume showed a median of 1.12% in the right ovary and 1.65% in the left ovary. When the estimate was calculated by spherical shape, the medians were 1.77% in the right ovary and 3.06% in the left ovary. There was a statistically significant difference in these two estimates (sphere, p = 0.008; cylinder, p = 0.021).ConclusionThe experimental animal model described for transvaginal ultrasound-guided ovarian needle cauterization seems to be feasible. The ovaries were successfully cauterized without injuries in needle path and more energy resulted in significantly more thermal lesion. The safety and effectiveness of this technique, theoretically less invasive than current ovarian drilling methods, could be tested in anovulatory women with PCOS.

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Section: Discussionsupporting

confidence: 91%

Adequacy of ovarian diathermy under ultrasound control: an experimental model

et al. 2013

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“…14 Similar to our study, Brett et al reported high degree of ICC of intra- and inter- observer variability for ovarian volume measurements. 24 However, the authors also proved that both methods were lacking from good inter- and intra- observer variability, particularly when estimating low ovarian volumes. In our study, 2D intra-observer variability was particularly poor when measuring smaller adrenal glands.…”

Section: Discussionmentioning

confidence: 94%

Comparative Analysis of 2-D Versus 3-D Ultrasound Estimation of the Fetal Adrenal Gland Volume and Prediction of Preterm Birth

Turan

Buhimschi

et al. 2012

Amer J Perinatol

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Objective We aim to test the hypothesis that 2D fetal AGV measurements offer similar volume estimates as volume calculations based on 3D technique Methods Fetal AGV was estimated by 3D ultrasound (VOCAL) in 93 women with signs/symptoms of preterm labor and 73 controls. Fetal AGV was calculated using an ellipsoid formula derived from 2D measurements of the same blocks (0.523× length × width × depth). Comparisons were performed by intra-class correlation coefficient (ICC), coefficient of repeatability, and Bland-Altman method. The cAGV (AGV/fetal weight) was calculated for both methods and compared for prediction of PTB within 7 days. Results Among 168 volumes, there was a significant correlation between 3D and 2D methods (ICC=0.979[95%CI: 0.971-0.984]). The coefficient of repeatability for the 3D was superior to the 2D method (Intra-observer 3D: 30.8, 2D:57.6; inter-observer 3D: 12.2, 2D: 15.6). Based on 2D calculations, a cAGV≥433mm3/kg, was best for prediction of PTB (sensitivity: 75%(95%CI=59-87); specificity: 89%(95%CI=82-94). Sensitivity and specificity for the 3D cAGV (cut-off ≥420mm3/kg) was 85%(95%CI=70-94) and 95%(95%CI=90-98), respectively. In receiver-operating-curve curve analysis, 3D cAGV was superior to 2D cAGV for prediction of PTB (z=1.99, p=0.047). Conclusion 2D volume estimation of fetal adrenal gland using ellipsoid formula cannot replace 3D AGV calculations for prediction of PTB.

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“…The weakness is the heterogeneity of the values obtained from diverse sources. We cannot be certain that the measurement of ovarian volume by abdominal ultrasound, which is often difficult in young children, is as accurate as measurement by transvaginal ultrasound in older females [28]. Similarly measurements taken at MRI may be different from those obtained by weighing the ovary following oophorectomy and calculating the volume from weight.…”

Section: Discussionmentioning

confidence: 97%

Ovarian Volume throughout Life: A Validated Normative Model

et al. 2013

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The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and is under investigation as a screening tool for ovarian cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n = 59,994) we have generated and robustly validated the first model of ovarian volume from conception to 82 years of age. This model shows that 69% of the variation in ovarian volume is due to age alone. We have shown that in the average case ovarian volume rises from 0.7 mL (95% CI 0.4–1.1 mL) at 2 years of age to a peak of 7.7 mL (95% CI 6.5–9.2 mL) at 20 years of age with a subsequent decline to about 2.8 mL (95% CI 2.7–2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis and management of a number of diverse gynaecological and reproductive conditions in females from birth to menopause and beyond.

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Individual ovarian volumes obtained from 2-dimensional and 3-dimensional ultrasound lack precision

Cited by 18 publications

References 27 publications

Adequacy of ovarian diathermy under ultrasound control: an experimental model

Adequacy of ovarian diathermy under ultrasound control: an experimental model

Comparative Analysis of 2-D Versus 3-D Ultrasound Estimation of the Fetal Adrenal Gland Volume and Prediction of Preterm Birth

Ovarian Volume throughout Life: A Validated Normative Model

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