Ovarian Volume throughout Life: A Validated Normative Model

Kelsey, Tom; Dodwell, Sarah K.; Wilkinson, A G; Grève, T.; Andersen, Claus Yding; Anderson, Richard A.; Wallace, W. Hamish B.

doi:10.1371/journal.pone.0071465

Cited by 78 publications

(60 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to a normative model, the ovarian volume enlargement occurs through childhood and adolescence to reach the maximum volume at 20 years of age, thereafter declining toward menopause and beyond (29). With respect to this model our nontreated volumes are close to the predicted values, and the treated volumes are substantially smaller.…”

Section: Discussionsupporting

confidence: 57%

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

Issaoui

Giorgione

Mamsen

et al. 2016

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

Objective: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse. Design: Retrospective case-control study. Setting: University hospitals. Patient(s): Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment. Intervention(s): None. Main Outcome Measure(s): Follicular densities (follicles/mm 3 ) measured from an ovarian cortical biopsy before OTC. The ovarian volume (mL) of entire ovaries excised for OTC was also monitored. Result(s): There was no statistically significant difference in the mean age or follicular density between groups 1 and 2 (334 AE 476/ mm 3 vs. 327 AE 756/mm 3 ). In contrast, the ovarian volume and total number of ovarian cortex chips cryopreserved were statistically significantly lower in patients who received gonadotoxic treatment before OTC (mean AE standard deviation [SD]: ovarian volume, 5.3 AE 3.1 mL vs. 2.9 AE 2.1 mL, respectively; number of cortex chips: 21.3 AE 8.1 vs. 15.2 AE 7.1, respectively). The reduction in the estimated ovarian reserve ranged from 10% to 20% in children to around 30% in adolescent girls (>10 years). Conclusion(s): Girls under the age of 10 tolerate a gonadotoxic insult better than adolescents, who may experience up to a 30% reduction in the ovarian reserve via first-line gonadotoxic treatment, which at present is considered to have little effect on the follicle pool. This information will improve counseling of young female cancer patients in deciding whether to undergo fertility preservation treatment. (Fertil Steril Ò 2016;106:1757-62.

show abstract

Section: Discussionsupporting

confidence: 57%

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

Issaoui

Giorgione

Mamsen

et al. 2016

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

show abstract

“…At the center of this controversy is the fact that the guidelines used to define PCOM overlap with the criteria for a multifollicular ovary especially when utilizing a transabdominal approach and follicle counts. The ovarian volume starts to increase with the onset of puberty, achieves maximum volume soon after (between menarche and age 16 years), and remains stable or decreases slightly thereafter [82][83][84][85] . Follicle number and size are also noted to increase with puberty, with a higher number of small follicles during adolescence and young adulthood and a decrease thereafter [84] .…”

Section: What Are the Criteria For Pcom In Adolescents?mentioning

confidence: 99%

“…Follicle number and size are also noted to increase with puberty, with a higher number of small follicles during adolescence and young adulthood and a decrease thereafter [84] . Isolated studies have also suggested the use of MRI or Doppler examination for the diagnosis of PCOM [85][86][87][88] . Dewailly et al [79] concluded that, when using transabdominal ultrasonography, an ovarian volume >10 cm 3 should be used because follicle counts become unreliable with this methodology.…”

Section: What Are the Criteria For Pcom In Adolescents?mentioning

confidence: 99%

The Diagnosis of Polycystic Ovary Syndrome during Adolescence

et al. 2015

View full text Add to dashboard Cite

dress a series of questions regarding the diagnosis of PCOS during adolescence including the following: clinical and biochemical evidence of hyperandrogenism, criteria for oligoanovulation and polycystic ovary morphology, diagnostic criteria to exclude other causes of hyperandrogenism and amenorrhea, role of insulin resistance, and intervention. Results and Conclusion: Features of PCOS overlap normal pubertal development. Hence, caution should be taken before diagnosing PCOS without longitudinal evaluation. However, treatment may be indicated even in the absence of a definitive diagnosis. While obesity, insulin resistance, and hyperinsulinemia are common findings in adolescents with hyperandrogenism, these features should not be used to diagnose PCOS among adolescent girls. © 2015 S. Karger AG, Basel Key WordsHyperandrogenism · Ovarian hyperandrogenism · Ovary · Polycystic ovary syndrome · Puberty Abstract Background/Aims: The diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescence are controversial, primarily because the diagnostic pathological features used in adult women may be normal pubertal physiological events. Hence, international pediatric and adolescent specialty societies have defined criteria that have sufficient evidence to be used for the diagnosis of PCOS in adolescents. Methods: The literature has been reviewed and evidence graded to ad-

show abstract

“…Maksymalną objętość jajniki osiągają w okresie pomiędzy menarche a 16 r.ż. [18], natomiast struktura wielopęcherzyko-wa nie zawsze świadczy o patologii. Istotny jest układ i rozmieszczenie pęcherzyków, ponieważ obecność licznych pęcherzyków ułożonych rów-nomiernie w całym jajniku nie może stanowić kryterium policystycznej morfologii jajników.…”

Section: Diagnostyka Pcos U Nastolatekunclassified

Thyroid disorders in adolescent girls with polycystic ovary syndrome

Skrzynska¹,

Zachurzok²,

Małecka-Tendera³

2017

Pediatr. Endocrinol.

View full text Add to dashboard Cite

In spite of long-term works analysing the relationship of thyroid diseases with the polycystic ovarian syndrome (PCOS), still a nosogenesis of the relation of above disease entities isn't clear. At women with hypothyroidismare being watched very often enlarging the volume of ovaries and their vesicular image in the ultrasound examination (ultrasound scan). On the other hand, increased spreading of thyroid diseases is observing by many researchers amongst women from PCOS in comparing to the population healthy women. They are pointing out to such PCOS and thyroid diseases connecting factors as the exaggerated amount of the fatty tissue, the high level of leptin whether insulinresistance. Also a possible auto-aggressive PCOS basis is more often emphasized. Pediatr. Endocrinol. 2017.16.2.59.121-126. © Copyright by PTEiDD 2017Słowa kluczowe tarczyca, autoimmunologia, zespół policystycznych jajników, hyperandrogenizm StreszczeniePomimo wieloletnich prac analizujących związek chorób tarczycy z zespołem policystycznych jajników (PCOS) wciąż nie jest jasna patogeneza zależności tych jednostek chorobowych. U kobiet z niedoczynnością tarczycy bardzo często obserwuje się powiększenie objętości jajników i ich pęcherzy-kowy obraz w badaniu ultrasonograficznym (USG). Z drugiej strony wielu badaczy obserwuje zwiększo-ne rozpowszechnienie chorób tarczycy wśród kobiet z PCOS w porównaniu do populacji kobiet zdrowych. Wskazuje się na takie czynniki łączące PCOS i choroby tarczycy, jak nadmierna ilość tkanki tłuszczowej, wysoki poziom leptyny czy insulinooporność. Coraz częściej podkreśla się także możliwe autoimmunizacyjne podłoże PCOS.

show abstract

Ovarian Volume throughout Life: A Validated Normative Model

Cited by 78 publications

References 41 publications

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years

The Diagnosis of Polycystic Ovary Syndrome during Adolescence

Thyroid disorders in adolescent girls with polycystic ovary syndrome

Contact Info

Product

Resources

About