Individual importance of olfaction decreases with duration of smell loss

Liu, David T.; Besser, Gerold; Prem, Bernhard; Speth, Marlene M.; Sedaghat, Ahmad R.; Mueller, Christian A.

doi:10.4193/rhin20.196

Cited by 14 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we previously found a negative correlation between duration of smell loss and the individual significance of olfaction, suggesting the possibility of internal frameshifts over time leading to less overall importance of olfaction to patients with OD. 25 Interestingly, orthonasal olfactory function (as measured with the Sniffin’ Sticks test) showed significant associations with the QOD-positive statement score in only our univariate regression model, not in multivariable analysis. However, this finding was not unexpected, since a previous study also reported no relevant correlation between measured olfactory function and the QOD-positive statement score of patients with OD.…”

Section: Discussionmentioning

confidence: 63%

See 1 more Smart Citation

Self‐perceived Taste and Flavor Perception: Associations With Quality of Life in Patients With Olfactory Loss

Liu

Besser

Prem

et al. 2020

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Objective To evaluate associations between self-perceived chemosensory functions of smell, taste, and flavor perception with olfactory-specific quality of life (QoL) in patients with olfactory dysfunction (OD) and whether these associations would be influenced by other factors, such as duration or etiology of smell loss. Study Design Retrospective cohort study. Setting Tertiary care, academic center. Methods Olfactory-specific QoL was measured with the Questionnaire of Olfactory Disorders (QOD). The QOD measures the impact of OD on QoL (QOD-negative statements) and the ability of patients to cope with smell loss (QOD-positive statements). Orthonasal olfactory function, patients’ demographics, self-perceived chemosensory perception, and duration and etiology of OD were retrospectively collected in a cohort of patients with quantitative OD. Correlations and multivariable linear regression models were computed to determine possible associations with the outcome measure of QOD-negative and QOD-positive statement scores. Results A total of 133 patients with OD were included. Analysis revealed a positive correlation between self-perceived taste and flavor perception with QOD-negative statement scores, while self-perceived smell showed no significant correlation. Similarly, longer duration of smell loss and higher age were also correlated with higher QOD-positive statement scores. Multivariable regression models confirmed that self-perceived taste was independently associated with the QOD-negative statement score, while age and duration of OD were independently associated with the QOD-positive statement score. Conclusions These findings suggest that the impact of diminished flavor perception during eating and drinking has a stronger impact on the QoL of patients with OD as compared with decreased orthonasal olfaction.

show abstract

Section: Discussionmentioning

confidence: 63%

“…Previous studies suggested that duration of smell loss and patient’s age might be correlated with greater coping with OD. 25 We therefore sought to determine whether these variables also show relevant correlations and associations in our cohort of patients with OD ( Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

Self‐perceived Taste and Flavor Perception: Associations With Quality of Life in Patients With Olfactory Loss

Liu

Besser

Prem

et al. 2020

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

“…Patients that were included in this analysis received OT for up to 9 months, which is longer than the usually recommended duration of treatment. Since OT is usually recommended for at least six months (twice on a daily base), informing patients (and thus increasing the likelihood of treatment adherence 28,29 ) remains a cornerstone during counseling.…”

Section: Discussionmentioning

confidence: 99%

Parosmia is Associated with Relevant Olfactory Recovery After Olfactory Training

et al. 2020

View full text Add to dashboard Cite

Objective/Hypothesis This study aims to determine the association between parosmia and clinically relevant recovery of olfactory function in patients with post‐infectious olfactory dysfunction (PIOD) receiving olfactory training. Study Design Retrospective cohort study. Methods This was a retrospective cohort study of patients with PIOD that received olfactory training. Adult patients with the major complaint of quantitative smell loss were recruited and treated at several ENT clinics in German between 2008 and 2018. The outcome was based on the association between smell‐loss related factors (including parosmia and phantosmia) and clinically relevant changes in overall and subdimension olfactory function of threshold, discrimination, and identification using binary logistic regression analysis. Results A total of 153 participants with PIOD were included. Clinically relevant improvements in overall olfactory function were more likely in those that had lower baseline olfactory function. Relevant improvements in discrimination function were more likely in those that had lower baseline olfactory function and those that had parosmia at the initial visit. Similarly, relevant improvements in odor identification were more likely in those that had a lower baseline olfactory function and in those who had parosmia at the first visit. Clinically significant improvements in odor threshold were more likely in those who were older in age. Conclusions This study demonstrated that the presence of parosmia is associated with clinically relevant recovery in olfactory discrimination and identification function in patients with PIOD receiving olfactory training. Level of Evidence 4 Laryngoscope, 131:618–623, 2021

show abstract

“…[42][43][44] In contrast, olfactory dysfunction has previously been found to not correlate with patientreported CRS control in comparison to other nasal symptoms. 38,39 Moreover, whereas olfactory dysfunction is associated with decreased quality of life, its relative importance to the patient appears to diminish over time 10 and is replaced by a focus on a dominant symptom such as nasal obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 However, chronic sinonasal inflammation due to CRS may also contribute to irreversible damage of the olfactory sensory nerves leading to the loss of smell that persists regardless of the control of sinonasal mucosal inflammation. Moreover, recent studies have indicated that the importance patients place on smell loss decreases with time 10 and is more weakly correlated with a decrease in quality of life when compared to nasal obstruction and rhinorrhea in CRS patients. 11 Based on these findings, we sought to determine the extent to which smell loss is a determinant of patient-reported CRS control, independent of symptoms of nasal obstruction and rhinorrhea.…”

Section: Introductionmentioning

confidence: 99%

Olfactory Dysfunction is not a Determinant Of Patient‐Reported Chronic Rhinosinusitis Disease Control

et al. 2020

View full text Add to dashboard Cite

Objectives/Hypothesis: As a cardinal symptom of chronic rhinosinusitis (CRS), hyposmia has been recommended to be assessed as a component of CRS disease control. Herein we determine the significance of hyposmia in CRS in the context of nasal obstruction and drainage symptoms.Study Design: Prospective, cross-sectional Methods: Cross-sectional study of 308 CRS patients (102 CRSwNP, 206 CRSsNP) without prior endoscopic sinus surgery. The burden of nasal obstruction and hyposmia were assessed using the corresponding item scores on the 22-item Sinonasal Outcome Test (SNOT-22). Burden of nasal discharge was assessed using the mean of "thick nasal discharge" and "thick post-nasal discharge" SNOT-22 item scores. Patients were all asked to rate their CRS symptom control as "not at all," "a little," "somewhat," "very," or "completely."Results: In CRSwNP, only 4.9% had a hyposmia score > 1 with nasal obstruction and drainage scores less than or equal to 1. In CRSsNP, only 1.9% had a hyposmia score > 1 with nasal obstruction and drainage scores less than or equal to 1. On univariate association, CRS symptom control was significantly associated with nasal obstruction, hyposmia, and drainage in both CRSwNP and CRSsNP (P < .05 in all cases). Using multivariable regression to account for all nasal symptoms, only nasal obstruction and nasal discharge scores (but not hyposmia) were significantly associated with CRS symptom control.Conclusions: Hyposmia rarely occurs without nasal obstruction or nasal drainage, and may therefore be redundant to assess for CRS disease control. Moreover, hyposmia was not associated with patient-reported CRS symptom control when accounting for the burden of nasal obstruction and drainage.

show abstract

Individual importance of olfaction decreases with duration of smell loss

Cited by 14 publications

References 39 publications

Self‐perceived Taste and Flavor Perception: Associations With Quality of Life in Patients With Olfactory Loss

Self‐perceived Taste and Flavor Perception: Associations With Quality of Life in Patients With Olfactory Loss

Parosmia is Associated with Relevant Olfactory Recovery After Olfactory Training

Olfactory Dysfunction is not a Determinant Of Patient‐Reported Chronic Rhinosinusitis Disease Control

Contact Info

Product

Resources

About