Individual Functional Anatomy of Verb Generation

Herholz, Karl; Thiel, Alexander; Wienhard, K.; Pietrzyk, U.; Stockhausen, H.-M. von; Karbe, H.; Keßler, Jörg‐U.; Bruckbauer, Thomas; Halber, Marco; Heiss, Wolf Dieter

doi:10.1006/nimg.1996.0020

Cited by 139 publications

(66 citation statements)

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“…We found that performing a grammatical manipulation with both verbs and pseudoverbs (compared to nouns and pseudonouns) reliably activated parts of the left rostral prefrontal cortex-in particular, in the left superior frontal gyrus, anterior and superior to regions damaged in a patient with selective difficulties in grammatical processing of verbs and pseudoverbs (Shapiro and Caramazza, 2003). Several previous PET studies have observed activation in this area for verb generation compared to silent rest (Crivello et al, 1995;Herholz et al, 1996;Warburton et al, 1996).…”

Section: Differences In Noun and Verb Processingmentioning

confidence: 55%

“…This is not necessarily true in the case of verbs: because plural morphology for verbs is merely a formal reflex of a structural relationship between words in an utterance, verb and pseudoverb processing might not have engaged areas involved in representing meaning to the same extent as noun processing. Moreover, it seems unlikely that the left superior frontal gyrus, which was engaged selectively for verb and pseudoverb production in this experiment, is critical for the retrieval of semantic information (although we cannot rule out this possibility, especially in light of evidence that the same cortical area may be involved in silent verb generation to noun cues; Crivello et al, 1995;Herholz et al, 1996).…”

Section: Bilateral Processing Of Nounsmentioning

confidence: 93%

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Dissociating neural correlates for nouns and verbs

et al. 2005

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Dissociations in the ability to produce words of different grammatical categories are well established in neuropsychology but have not been corroborated fully with evidence from brain imaging. Here we report on a PET study designed to reveal the anatomical correlates of grammatical processes involving nouns and verbs. German-speaking subjects were asked to produce either plural and singular nouns, or first-person plural and singular verbs. Verbs, relative to nouns, activated a left frontal cortical network, while the opposite contrast (nouns-verbs) showed greater activation in temporal regions bilaterally. Similar patterns emerged when subjects performed the task with pseudowords used as nouns or as verbs. These results converge with findings from lesion studies and suggest that grammatical category is an important dimension of organization for knowledge of language in the brain. D

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Section: Differences In Noun and Verb Processingmentioning

confidence: 55%

Section: Bilateral Processing Of Nounsmentioning

confidence: 93%

Dissociating neural correlates for nouns and verbs

et al. 2005

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“…This type of variability, in the sets of cortical areas active across individuals, was once more found in our estimated sources of beta activity during the present visual attention and reasoning tasks: no single cortical area was seen to be active in all subjects. This variability is also met with in the unfortunately few fMRI studies that present individual data [8][9][10][11][12][13][14], some even during passive sensory stimulation [11,12]. Nevertheless, the concern with individual variability is now an important issue in fMRI research, but typically of a different kind, regarding the extent and amplitudes of task-related changes in given brain regions, frequently pre-selected 'regions of interest' (ROIs).…”

Section: Individual Variability In Active Association Areas and Functmentioning

confidence: 99%

“…The proposed methodological improvements center in the transformations of individual data (coordinates of peak changes) to a common 'space', previous to group spatial averaging [5][6][7]. In few cases we find the concern to preserve individual data and an explicit advice against group spatial averaging [8][9][10][11][12][13][14]. The methods of analysis and interpretation in those studies would typically range from simple data tabulation to 'fuzzy clustering' [28] or 'multisubject network' [29,30] approaches.…”

Section: Individual Variability In Active Association Areas and Functmentioning

confidence: 99%

“…Its acknowledgement has even motivated the development of new approaches to present and interpret fMRI results [5][6][7]. In particular, it suggests the inadequacy of the use of spatial averaging of task-related physiological changes across subjects [8][9][10][11][12][13][14], in some cases even for sensory activity [11,12]. For this reason, our main intention in the present work was to devise means of comparing task-related results within-individuals.…”

Section: Introductionmentioning

confidence: 99%

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Lack of systematic topographic difference between attention and reasoning beta correlates

Basile

Alvarenga

Henrique

et al. 2012

International Journal of Psychophysiology

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Based on previous evidence for individual-specific sets of cortical areas active during simple attention tasks, in this work we intended to perform within individual comparisons of task-induced beta oscillations between visual attention and a reasoning task. Since beta induced oscillations are not time-locked to task events and were first observed by Fourier transforms, in order to analyze the cortical topography of attention induced beta activity, we have previously computed corrected-latency averages based on spontaneous peaks of band-pass filtered epochs. We then used Independent Component Analysis (ICA) only to single out the significant portion of averaged data, above noise levels. In the present work ICA served as the main, exhaustive means for decomposing beta activity in both tasks, using 128-channel EEG data from 24 subjects. Given the previous observed similarity between tasks by visual inspection and by simple descriptive statistics, we now intended another approach: to quantify how much each ICA component obtained in one task could be explained by a linear combination of the topographic patterns from the other task in each individual. Our hypothesis was that the major psychological difference between tasks would not be reflected as important topographic differences within individuals. Results confirmed the high topographic similarity between attention and reasoning beta correlates in that few components in each individual were not satisfactorily explained by the complementary task, and if those could be considered ''taskspecific'', their scalp distribution and estimated cortical sources were not common across subjects. These findings, along with those from fMRI studies preserving individual data and conventional neuropsychological and neurosurgical observations, are discussed in support of a new functional localization hypothesis: individuals use largely different sets of cortical association areas to perform a given task, but those individual sets do not change importantly across tasks that differ in major psychological processes.

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Right Anterior Cingulate Cortex Infarction and Transient Speech Aspontaneity

Chang¹,

Lee²,

Lui³

et al. 2007

Arch Neurol

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Background: According to recent functional studies, the medial frontal lobe of the dominant hemisphere plays a role in both word generation and speech initiation. To our knowledge, speech arrest with intact facial expression secondary to the right anterior cingulate cortex (ACC) lesion has not been previously reported. Objective: To report 2 cases of speech initiation difficulties associated with a stroke of the right anterior cingulate gyrus with magnetic resonance imaging with tractography results. Design: Two case reports. Setting: Inpatient neurology clinic at a university medical center. Patients: Two women who had acute and transient speech initiation problems. Results: Speech evaluation revealed pure speech initia-REPORT OF CASES CASE 1 An 82-year-old right-handed woman suffered from acute-onset speech loss and transient left-side weakness. Two weeks

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Individual Functional Anatomy of Verb Generation

Cited by 139 publications

References 0 publications

Dissociating neural correlates for nouns and verbs

Dissociating neural correlates for nouns and verbs

Lack of systematic topographic difference between attention and reasoning beta correlates

Right Anterior Cingulate Cortex Infarction and Transient Speech Aspontaneity

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