Individual differences in pain responses

Fillingim, Roger B.

doi:10.1007/s11926-005-0018-7

Cited by 203 publications

(134 citation statements)

References 54 publications

(47 reference statements)

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“…Results from such studies have reported lower pain thresholds and tolerances among African American subjects compared to non-Hispanic white subjects across multiple experimental pain modalities. Findings from this study support and extend similar pain investigations (Fillingim 2005;Edwards et al 2003;Campbell 2004Campbell ,2005Edwards and Fillingim 1999;and Zatzick and Dimsdale 1990). Although several studies have addressed ethnic differences and pain response in clinical studies (Edwards et al 2005Green 2005Green ,2003Campbell et al 2004;Riley 2002;Greenwald 1991), and some have included multiple ethnic groups (Edwards et al 2005;Hastie, et al 2005;Watson et al 2005;Faucett et al 1994;Lawlis et al 1984;Lipton and Marbach 1984), a unique contribution of this study is the inclusion of both Hispanics and African Americans in a comparative study of experimental pain and ethnic identity.…”

Section: Discussionsupporting

confidence: 83%

Ethnic identity predicts experimental pain sensitivity in African Americans and Hispanics

Rahim-Williams¹,

Riley²,

Herrera³

et al. 2007

Pain

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223

169

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The aim of this study was to examine experimental pain sensitivity in three ethnic groups, African Americans, Hispanic Americans and non-Hispanic whites, and to determine whether ethnic identity is differentially associated with pain sensitivity across ethnic groups. Participants included sixtythree African American, sixty-one Hispanic and eighty-two non-Hispanic white participants who were assessed using three experimental pain measures: thermal, cold-pressor and ischemic. Participants' ethnic identity was assessed using the Multi-group Ethnic Identity Measure (MEIM). Ethnic group differences in pain responses were observed, with African American and Hispanic subjects showing lower cold and heat pain tolerances than non-Hispanic whites. In addition, pain range (i.e. tolerance -threshold) was computed for heat, cold and ischemic pain, and the two minority groups again had lower values compared to non-Hispanic whites. Ethnic identity was associated with pain range only for African American and Hispanic groups. Statistically controlling for ethnic identity rendered some of the group differences in pain range non-significant. These findings indicate that ethnic identity is associated with pain sensitivity in ethnic minority groups, and may partially mediate group differences in pain perception. The results of the present investigation provide evidence of ethnic group differences in responses to experimental pain across multiple noxious stimuli, with both minority groups exhibiting greater sensitivity to laboratory evoked pain compared to non-Hispanic whites.

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Section: Discussionsupporting

confidence: 83%

Ethnic identity predicts experimental pain sensitivity in African Americans and Hispanics

Rahim-Williams¹,

Riley²,

Herrera³

et al. 2007

Pain

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223

169

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“…Pain is expected after injury and surgery [3], although the extent to which patients experience pain varies [16,18,40]. Pain is the cognitive and emotional response to nociception [7,13,36].…”

Section: Introductionmentioning

confidence: 99%

Opioid Use After Fracture Surgery Correlates With Pain Intensity and Satisfaction With Pain Relief

Bot

Bekkers

Arnstein

et al. 2014

Clinical Orthopaedics &Amp; Related Research

158

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Background In 2012, Medicare began to tie reimbursements to inpatient complications, unplanned readmissions, and patient satisfaction, including satisfaction with pain management. Questions/purposes We aimed to identify factors that correlate with (1) pain intensity during a 24-hour period after surgery; (2) less than complete satisfaction with pain control; (3) less than complete satisfaction with staff attention to pain relief while in the hospital; and we also wished (4) to compare inpatient and discharge satisfaction scores. Methods Ninety-seven inpatients completed measures of pain intensity (numeric rating scale), satisfaction with pain relief, self-efficacy when in pain, and symptoms of depression days after operative fracture repair. The amount of opioid used in oral morphine equivalents taken during the prior 24 hours was calculated. Through initial bivariate One of the authors (AGJB) certifies that he, or a member of his immediate family, has or may receive payments or benefits, during the study period from ''AnnaFonds Travel grant'' (Dutch Orthopaedic travel grant), Leiden, the Netherlands (less than USD 10,000); ''VSBfonds'', Utrecht, the Netherlands, a nonmedical study grant (less than USD 10,000); and ''Prins Bernhard Cultuurfonds, Banning-de Jong fonds'', Amsterdam, the Netherlands, a nonmedical study grant (less than USD 10,000). One of the authors (SB) certifies that he, or a member of his immediate family, has or may receive payments or benefits, during the study period, an amount of less than 10,000 USD from a VU University ''Faculty Fund'', Amsterdam, the Netherlands. One of the authors (PMA) has received funding from Connell Nursing Research Scholarship (less than USD 10,000); the Nurse Practitioner Healthcare Foundation (less than USD 10,000); the American Pain Society and the American Association of Nurse Practitioners (less than USD 10,000); the Nurse Practitioner Healthcare Foundation (less than USD 10,000); and F.D. Davis Publishers (less than USD 10,000). One of the authors (DR) certifies that he, or a member of his immediate family, has or may receive payments or benefits, during the study period from a study-specific grant from Skeletal Dynamics (USD 10,000-100,000) (Miami, FL, USA); is a consultant for Wright Medical (Memphis, TN, USA), Skeletal Dynamics, and Biomet (Warsaw, IN, USA) (less than USD 10,000); received honoraria from AO North America (Paoli, PA, USA), and AO International (less than USD 10,000); and received royalties from Wright Medical (less than USD 10,000). All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request. Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained. and then multivariate analysis, we identified factors that we...

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“…Cultural differences in gender-specific pain patterns would suggest sociocultural mechanisms, or possibly racial differences, whereas similarities across cultures would suggest biological or biopsychological mechanisms (e.g., [181]). There is evidence that culture/race interacts with gender on the experience of pain [59,147]. Future cross-cultural studies could be useful for illuminating mechanisms underlying sex differences in pain, although cultural and genetic factors may be difficult to differentiate.…”

mentioning

confidence: 99%

Studying sex and gender differences in pain and analgesia: A consensus report

Greenspan

Craft

LeResche

et al. 2007

Pain

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861

633

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In September 2006, members of the Sex, Gender and Pain Special Interest Group of the International Association for the Study of Pain met to discuss the following: (1) what is known about sex and gender differences in pain and analgesia; (2) what are the "best practice" guidelines for pain research with respect to sex and gender; and (3) what are the crucial questions to address in the near future? The resulting consensus presented herein includes input from basic science, clinical and psychosocial pain researchers, as well as from recognized experts in sexual differentiation and reproductive endocrinology. We intend this document to serve as a utilitarian and thought-provoking guide for future research on sex and gender differences in pain and analgesia, both for those currently working in this field as well as those still wondering, "Do I really need to study females?" Keywords Sex differences; Gonadal hormones; Estrogens The case for studying sex and gender differences in pain and analgesiaThe pain field has moved from debating whether sex differences in pain exist to recognizing the importance of these differences. Attention is now directed toward understanding (1) what conditions lead to the expression of sex and gender differences in pain experience and reactivity, (2) what mechanisms underlie these differences, and (3) how these differences can inform clinical management of pain.As noted in a recent review, at least 79% of animal studies published in Pain over the preceding 10 years included male subjects only, with a mere 8% of studies on females only, and another 4% explicitly designed to test for sex differences (the rest did not specify) [142]. Given the substantially greater prevalence of many clinical pain conditions in women vs. men [20,199], and growing evidence for sex differences in sensitivity to experimental pain and to analgesics [21,41,213], we recommend that all pain researchers consider testing their hypotheses in both sexes, or if restricted by practical considerations, only in females. It is invalid to assume that data obtained in male subjects will generalize to females, and the best non-human model of the modal human pain sufferer -a woman -is a female animal. If only males are examined in a given study, it is important that a rationale for exclusion of females be provided and that the potential limitation in generalizability of the findings be addressed in the discussion, particularly when examining a pain phenomenon that occurs with greater prevalence or severity in females. In both preclinical and clinical studies, a comparison of both sexes will further our understanding of individual differences in sensitivity to pain and analgesia, thus improving our ability to treat and prevent pain in all people. General considerationsTwo issues of terminology are important. First, the term "sex" refers to biologically based differences, while the term "gender" refers to socially based phenomena. Although biological sex exerts a major influence on one's gender identity, sex and gender a...

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Individual differences in pain responses

Cited by 203 publications

References 54 publications

Ethnic identity predicts experimental pain sensitivity in African Americans and Hispanics

Ethnic identity predicts experimental pain sensitivity in African Americans and Hispanics

Opioid Use After Fracture Surgery Correlates With Pain Intensity and Satisfaction With Pain Relief

Studying sex and gender differences in pain and analgesia: A consensus report

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