No abstract

A tumor cell line was derived from the fibrosarcoma of a 35‐year‐old Caucasian man who died without having received chemotherapy or radiotherapy. The in vitro growth properties and transplantability into antithymocytic sera treated mice were characteristic of these malignant cells. An aberrant karyology with marker chromosomes was present. No virus particles were detected.

To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability develops and why so many chronic pain patients become depressed. Questionnaires from 126 chronic pain patients (without prior depression) were reviewed from three pain clinics. Hypothesized and alternate models were tested using separate regression equations to identified models which best fit these data. Regression analysis supported that self efficacy partially mediates the relationship between pain intensity and disability. This model accounted for 47% of the explained variance in disability (P < 0.001). Six additional variables that were significantly related to disability in preliminary analysis, added to the explained variance in disability (R2 = 0.56), with gender and pain location paths remaining significant. In separate regression analyses, disability was found to partially mediate the relationship between pain intensity and depression (b = 0.47-0.33). This model accounted for 26% of the explained variance in depression. The addition of self efficacy to this model supported it as a stronger mediator (R2 = 0.32), and suggested that support for disability as a mediator of depression was a spurious finding. Both pain intensity and self efficacy contribute to the development of disability and depression in patients with chronic pain. Therefore, the lack of belief in ones own ability to manage pain, cope and function despite persistent pain, is a significant predictor of the extent to which individuals with chronic pain become disabled and/or depressed. Nevertheless, these mediators did not eliminate the strong impact that high pain intensity has on disability and depression. Therefore, therapy should target multiple goals, including: pain reduction, functional improvement and the enhancement of self efficacy beliefs.

Self efficacy in an important variable contributing to the disability of chronic pain patients. Therefore, evaluating and bolstering the patient's belief in their own abilities may be an important component of therapy.

Recent investigations have begun to dissect the number and nature of genetic alterations associated with cancer cells. In the present study, primary human epidermal keratinocytes acquired indefinite life-span in culture but did not undergo malignant conversion in response to infection with a hybrid of adenovirus 12 and simian virus 40. Addition of Kirsten murine sarcoma virus, which contains a K-ras oncogene, to these cells induced morphological alterations associated with the acquisition of neoplastic properties. These findings demonstrate the malignant transformation of human primary epithelial cells in culture and support a multiple-step process for neoplastic conversion.

No abstract

Background In 2012, Medicare began to tie reimbursements to inpatient complications, unplanned readmissions, and patient satisfaction, including satisfaction with pain management. Questions/purposes We aimed to identify factors that correlate with (1) pain intensity during a 24-hour period after surgery; (2) less than complete satisfaction with pain control; (3) less than complete satisfaction with staff attention to pain relief while in the hospital; and we also wished (4) to compare inpatient and discharge satisfaction scores. Methods Ninety-seven inpatients completed measures of pain intensity (numeric rating scale), satisfaction with pain relief, self-efficacy when in pain, and symptoms of depression days after operative fracture repair. The amount of opioid used in oral morphine equivalents taken during the prior 24 hours was calculated. Through initial bivariate One of the authors (AGJB) certifies that he, or a member of his immediate family, has or may receive payments or benefits, during the study period from ''AnnaFonds Travel grant'' (Dutch Orthopaedic travel grant), Leiden, the Netherlands (less than USD 10,000); ''VSBfonds'', Utrecht, the Netherlands, a nonmedical study grant (less than USD 10,000); and ''Prins Bernhard Cultuurfonds, Banning-de Jong fonds'', Amsterdam, the Netherlands, a nonmedical study grant (less than USD 10,000). One of the authors (SB) certifies that he, or a member of his immediate family, has or may receive payments or benefits, during the study period, an amount of less than 10,000 USD from a VU University ''Faculty Fund'', Amsterdam, the Netherlands. One of the authors (PMA) has received funding from Connell Nursing Research Scholarship (less than USD 10,000); the Nurse Practitioner Healthcare Foundation (less than USD 10,000); the American Pain Society and the American Association of Nurse Practitioners (less than USD 10,000); the Nurse Practitioner Healthcare Foundation (less than USD 10,000); and F.D. Davis Publishers (less than USD 10,000). One of the authors (DR) certifies that he, or a member of his immediate family, has or may receive payments or benefits, during the study period from a study-specific grant from Skeletal Dynamics (USD 10,000-100,000) (Miami, FL, USA); is a consultant for Wright Medical (Memphis, TN, USA), Skeletal Dynamics, and Biomet (Warsaw, IN, USA) (less than USD 10,000); received honoraria from AO North America (Paoli, PA, USA), and AO International (less than USD 10,000); and received royalties from Wright Medical (less than USD 10,000). All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request. Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained. and then multivariate analysis, we identified factors that we...

No abstract