Individual and joint contribution of family history andHelicobacter pylori infection to the risk of gastric carcinoma

Brenner, Hermann; Arndt, Volker; Stürmer, Til; Stegmaier, Christa; Ziegler, H; Dhom, G.

doi:10.1002/(sici)1097-0142(20000115)88:2<274::aid-cncr5>3.0.co;2-9

Cited by 139 publications

(88 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…26,27 Participants with 2 or more affected relatives had a highly increased risk, however, an effect stratified subanalysis revealed to be greater in the age-group from 40 -59 and these findings are consistent with a previous report on the relation between the risk of colon cancer and family history, which concluded that the disease occurs as a result of a partially penetrant inherited susceptibility. 28 There is also accumulating knowledge about the molecular mechanisms underlying familial aggregation of stomach cancer.…”

Section: Family History and Stomach Cancersupporting

confidence: 90%

See 1 more Smart Citation

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Yatsuya

Toyoshima

Mizoue

et al. 2001

Intl Journal of Cancer

View full text Add to dashboard Cite

Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95% CI 1.11-2.31) and women (RR 2.47; 95% CI 1.50 -4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40 -59 (RR 2.62; 95% CI 1.34 -5.11 for men and RR 5.88; 95% CI 2.70 -12.82 for women) than in the age group from 60 -79 (RR 1.31; 95% CI 0.84 -2.05 for men and RR 1.44; 95% CI 0.72-2.88 for women). In the age group from 40 -59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95% CI 1.51-6.55, RR 10.46; 95% CI 4.54 -24.12, RR 13.39; 95% CI 3.89 -46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95% CI 4.46 -20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility.

show abstract

Section: Family History and Stomach Cancersupporting

confidence: 90%

“…Further investigation of the family history in consideration of molecular traits such as E-cadherin gene 35 or transforming growth factor beta-1 30 and interaction with Helicobacter pylori infection 26 are needed to solve these questions.…”

Section: Family History and Stomach Cancermentioning

confidence: 99%

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Yatsuya

Toyoshima

Mizoue

et al. 2001

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Estudos epidemiológicos têm demonstrado risco aumentado de até 6 vezes para o desenvolvimento de adenocarcinoma gástrico em indivíduos infectados pelo H. pylori (2,13,14,29) . O adenocarcinoma gástrico atinge altas taxas de incidência em países orientais como China e Japão, especialmente quando comparadas com as taxas encontradas no ocidente.…”

Section: Resultsunclassified

Prevalência da infecção por Helicobacter pylori e das lesões precusoras do câncer gástrico em pacientes dispéticos

Müller

Fagundes

Moraes

et al. 2007

Arq. Gastroenterol.

View full text Add to dashboard Cite

RESUMO -Racional -A infecção pelo Helicobacter pylori é fator importante no desenvolvimento da carcinogênese gástrica, mas somente uma fração dos pacientes infectados irá desenvolver câncer gástrico. A infecção pelo H. pylori determina gastrite crônica não-atrófica, que pode evoluir para gastrite atrófica e metaplasia intestinal e, finalmente, para displasia e adenocarcinoma. , 3% e 15% das biopsias, respectivamente. A infecção por H. pylori determinou uma razão de chances 10 vezes (IC95% 6.50 -17%) maior de se encontrar algum grau de alteração histológica na mucosa gástrica. A razão de chances dos pacientes infectados apresentarem gastrite crônica não-atrófica, foi igual a 3 (IC95% 2,2 -3,4). A razão de chances dos pacientes infectados apresentarem gastrite atrófica e metaplasia intestinal foi menor que 1. Conclusão -A prevalência da infecção por H. pylori foi alta (76%) e os indivíduos infectados apresentaram probabilidade 10 vezes maior para a ocorrência de lesão da mucosa gástrica. Gastrite crônica não-atrófica apresentou prevalência de 77%, gastrite atrófica 3% e metaplasia intestinal 15%. A infecção pelo H. pylori determinou uma probabilidade 3 vezes maior para o desenvolvimento de gastrite crônica não-atrófica e não determinou risco para a ocorrência de gastrite atrófica e metaplasia intestinal, sugerindo que possivelmente outros fatores de risco, além do H. pylori, estejam envolvidos no processo da carcinogênese gástrica. DESCRITORES -Infecções por Helicobacter. Neoplasias gástricas. Condições pré-cancerosas. Dispepsia. INTRODUÇÃOO câncer gástrico é a segunda causa mais comum de morte por câncer no mundo e quase dois terços dos casos ocorrem em países em desenvolvimento (28) . Progresso significante na etiologia do câncer gástrico foi a identificação do Helicobacter pylori (H. pylori) e as evidências acumuladas que levaram a sua classificação como fator importante ligado ao processo da carcinogênese gástrica. No entanto, tem-se observado grande heterogeneidade entre as populações, no que diz respeito ao risco do desenvolvimento de câncer gástrico associado à infecção pelo H. pylori, notando-se que nas populações com alta prevalência da infecção somente uma fração da mesma irá desenvolver câncer gástrico (15) .Estudos da mucosa gástrica em populações de alto risco têm revelado uma série de lesões que, seqüencialmente, evoluiriam da condição normal para gastrite crônica não-atrófica (GCNA), que evoluiria para gastrite atrófica (GA) e metaplasia intestinal (MI) e, finalmente, para displasia e adenocarcinoma (7,8,10,35) . Portanto, a infecção pelo

show abstract

“…The 95 % confidence interval is given in parentheses diffuse type [4], further detailed study is needed. Second, there are no data on infection with H. pylori, a strong risk factor for GC with familial clustering [42]. However, as there is no report that MMP9 R279Q polymorphism has some influence on susceptibility to H. pylori infection or the progression to atrophic gastritis due H. pylori infection, the lack of data on H. pylori infection may not influence the result in this analysis.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

et al. 2016

View full text Add to dashboard Cite

Background A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/ TIMP genes. Methods We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35-69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. Results MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 % vs 11.6 %, OR 4.34, 95 % confidence interval (CI) 1.45-13.03 and 16.7 % vs 11.6 %, OR 2.26, 95 % CI 0.81-6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 %. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and

show abstract

Individual and joint contribution of family history andHelicobacter pylori infection to the risk of gastric carcinoma

Cited by 139 publications

References 25 publications

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Prevalência da infecção por Helicobacter pylori e das lesões precusoras do câncer gástrico em pacientes dispéticos

Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

Contact Info

Product

Resources

About