Indium-111 leukocyte imaging in appendicitis

Navarro, Daniel; Weber, P; Kang, Isamu Y.; Remedios, Leo V. dos; Jasko, Ivan A.; Sawicki, John E.

doi:10.2214/ajr.148.4.733

Cited by 20 publications

(6 citation statements)

References 3 publications

(1 reference statement)

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“…Barium enema examination is not obsolete, however, and may be useful in evaluating complex colonic abnormalities detected with cross-sectional imaging (51). While investigators have explored the potential of magnetic resonance imaging (97) and radioactive isotope imaging (98,99) in patients with acute appendicitis, there is no current practical role for these imaging modalities in this patient population.…”

Section: Us Versus Ctmentioning

confidence: 99%

Appendicitis at the Millennium

Birnbaum¹,

Wilson²

2000

Radiology

536

430

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Acute appendicitis is a common clinical problem. Accurate and prompt diagnosis is essential to minimize morbidity. While the clinical diagnosis may be straightforward in patients who present with classic signs and symptoms, atypical presentations may result in diagnostic confusion and delay in treatment. Helical computed tomography (CT) and graded compression color Doppler ultrasonography (US) are highly accurate means of establishing the diagnosis. These imaging modalities have now assumed critical roles in the treatment of patients suspected to have appendicitis. The purpose of this article is threefold: to provide an update on new information regarding the pathophysiology, clinical diagnosis, and laparoscopic treatment of acute appendicitis; to describe the state-of-the art use of CT and US in diagnosing this disease entity; and to address the role of medical imaging in this patient population.

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Section: Us Versus Ctmentioning

confidence: 99%

Appendicitis at the Millennium

Birnbaum¹,

Wilson²

2000

Radiology

536

430

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“…Various scintigraphic methods have been reported to contribute to the diagnosis of appendicitis. Successful results were obtained with 99m Tc-or 111 Inlabeled leukocyte scan [7,9]. However, the difficulties and disadvantages of these methods are obtaining 50-90 ml whole blood from the patient, the probability of contamination of the blood obtained, time-consuming steps involved in the labeling process of leukocytes, delayed imaging for optimum results and high costs.…”

Section: Discussionmentioning

confidence: 99%

“…Many imaging methods have been used for differential diagnosis [1]. There are a few reports about the radionuclide imaging of acute appendicitis [6,7,9]. The present experimental study was planned to evaluate and compare 99m Tc-citrate, 67 Ga-citrate and 99m Tc(V) DMSA as agents for the scintigraphic visualization of acute appendicitis.…”

mentioning

confidence: 99%

Evaluation of 99mTc-citrate, 67Gacitrate and 99mTc(V) dimercaptosuccinic acid for the scintigraphic visualization of acute appendicitis

et al. 1997

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An experimental study was planned to evaluate 99mTc-citrate, 67Ga-citrate and 99mTc(V) dimercaptosuccinic acid (DMSA) as agents for the visualization of acute appendicitis. Appendiceal ligation was performed through a midline incision in 24 rabbits. Twenty-four hours later the animals were divided into three equal groups. The rabbits were injected through the aurical vein with 1 mCi (37 MBq) 99mTc-citrate in group I, 0.5 mCi (18.5 MBq) 67Ga-citrate in group II and 1 mCi (37 MBq) 99mTc(V) DMSA in group III. After 3 h, static images of the rabbits were obtained with a gamma camera. There were positive images in seven, six and five rabbits in groups I, II and III respectively. The image quality was better in group I than in the other groups. Also, the mean uptake in group I was significantly higher than those of other two groups (P < 0.05). There was no significant difference between groups II and III (P > 0.05). All rabbits had appendicitis confirmed histologically. In conclusion, these results show that 99mTc-citrate is preferable to 67Ga-citrate and 99mTc(V) DMSA for the differential diagnosis of acute abdominal inflammations such as appendicitis, because of higher concentration ratios, simple and rapid preparation, low cost, excretion mainly through the kidneys and fast blood clearance.

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“…Thus, nuclear infection and inflammation imaging methods are rarely performed for AA. Previous studies have reported the use of Indium-111 and 99m Tc-HMPAO-labelled leukocyte scintigraphy, 99m Tc-labelled human immune globulin and anti-granulocyte antibodies in AA cases [10,11]. In recent years, incidental cases of AA have been identified during 18 F-FDG PET/CT scans for oncologic screening [12][13][14][15].…”

Section: Gallium-68 Citrate Pet/ct Findings In An Experimental Model mentioning

confidence: 99%

Gallium-68 citrate PET/CT findings in an experimental model of acute appendicitis in rabbits

Gültekin¹,

Uzunlu²,

Uğur³

et al. 2020

Preprint

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Objective Acute appendicitis (AA) is the most common abdominal surgical emergency worldwide. Several infection and inflammation imaging methods have been used in a limited number of cases. Gallium-68 ( 68 Ga) has recently been investigated as an infection and inflammation imaging agent. The aim of our study was to produce 68 Ga-citrate in an automated synthesis unit and perform 68 Ga-citrate PET/CT imaging in rabbits with experimentally induced AA. Furthermore, this study aimed to investigate and correlate PET/CT findings with those of histopathological and biochemical examinations. Methods 68 Ga-citrate was synthesized using the cationic method in an automatic synthesis unit. Twelve rabbits of the New Zealand strain ( Oryctolagus cuniculus ) were divided into two groups. In the AA group (n = 6), the appendices of the rabbits were surgically ligated. In the sham group (n = 6), the abdomen was surgically opened and closed. All rabbits were imaged using 68 Ga-citrate PET/CT at 12, 24 and 36 h following the establishment of the experimental models, and at 36 h, all rabbits were appendectomised. Appendices were examined histopathologically and blood samples were drawn from all rabbits at the beginning and end of the experimental process. Interleukin-6 (IL-6) and procalcitonin (Pct) levels were measured. PET/CT results were compared statistically with histopathological and biochemical references. Results The labelling efficiency of 68 Ga-citrate was more than 98%. The sensitivity, specificity and accuracy of 68 Ga-citrate PET/CT in AA were 100%, 83.3% and 81.7%, respectively. IL-6 and Pct levels at 36 h in the AA group were significantly higher than those in the sham group and at baseline (p < 0.05). Conclusions 68 Ga-citrate was synthesized in an automatic synthesis unit for the first time, and 68 Ga-citrate uptake was shown using PET/CT in a histopathologically and biochemically confirmed experimental AA rabbit model.

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Indium-111 leukocyte imaging in appendicitis

Cited by 20 publications

References 3 publications

Appendicitis at the Millennium

Appendicitis at the Millennium

Evaluation of 99mTc-citrate, 67Gacitrate and 99mTc(V) dimercaptosuccinic acid for the scintigraphic visualization of acute appendicitis

Gallium-68 citrate PET/CT findings in an experimental model of acute appendicitis in rabbits

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