Indirect Self-Destructiveness in Hidradenitis Suppurativa Patients

Głowaczewska, Amelia; Reszke, Radomir; Szepietowski, Jacek C.; Matusiak, Łukasz

doi:10.3390/jcm10184194

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…The enormous effect that HS has on the QoL of patients, their families, and their partners due to the pain, itchiness, purulent discharge, and foul smell caused by the disease has been documented [16,17]. The disease is associated with a higher incidence of depression, suicidal thoughts, stigmatization, alexithymia, and unemployment [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

The Use of HSQoL-24 in an Assessment of Quality-of-Life Impairment among Hidradenitis Suppurativa Patients: First Look at Real-Life Data

Krajewski

Marrón

Gómez-Barrera

et al. 2021

JCM

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with well-documented effects on patients’ quality of life (QoL). The aim of this study was to evaluate the QoL of patients with HS via the use of a newly developed questionnaire: Hidradenitis Suppurativa Quality of Life-24 (HSQoL-24). This study was performed on a population of 342 HS patients. Their QoL was assessed via the HSQoL-24 questionnaire. The perceived impairment of QoL due to HS in the studied group was considered to be serious (mean HSQoL-24 score: 58.3 ± 21.0 points). Women tended to experience a significantly higher impact from the disease than men (61.6 ± 19.2 points vs. 51.1 ± 23.1 points, p < 0.001). The HS severity had an effect on the perceived QoL, with statistically significant differences being evident between the self-assessed HS severity groups. The level of QoL impairment correlated positively with the number of affected body areas (r = 0.285, p < 0.001) and the duration of the disease (r = 0.173, p = 0.001), while the patients’ age at disease onset correlated negatively with the HSQoL-24 global score (r = −0.182, p = 0.001). Patients living in their family house scored higher than other groups. The least affected were patients who lived alone. The study shows that the HSQoL-24 questionnaire is a reliable, HS-specific tool for measuring the QoL among patients with HS in real-life clinical settings.

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Section: Discussionmentioning

confidence: 99%

The Use of HSQoL-24 in an Assessment of Quality-of-Life Impairment among Hidradenitis Suppurativa Patients: First Look at Real-Life Data

Krajewski

Marrón

Gómez-Barrera

et al. 2021

JCM

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“…It involves 28 statements that are included in 14 coping strategies (2 statements in each strategy). The following strategies are analyzed: active coping (items 2, 7), planning (items 14, 25), positive reframing (items 12,17), acceptance (items 20, 24), sense of humor (items 18, 28), turning to religion (items 22, 27), seeking emotional support (items 5, 15), seeking informational support (items 10, 23), self-distraction (items 1, 19), denial (items 3, 8), venting (items 9, 21), substance use (items 4, 11), behavioral disengagement (items 6, 16) and selfblame (items 13, 26). For each statement, the respondent marks 1 out of 4 possible answers, which are scored: "I almost never do this" (0 points), "I rarely do this" (1 point), "I often do this" (2 points) and " I almost always do that "(3 points).…”

Section: Coping Strategiesmentioning

confidence: 99%

“…In the light of the above-described clinical manifestations, HS is likely to cause notable psychological distress [11][12][13][14][15]. Moreover, our recent study suggested that reasonable number of HS patients suffered from mental disorders, namely, depression and anxiety [16].…”

Section: Introductionmentioning

confidence: 97%

Satisfaction with Life and Coping Strategies among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study

Rymaszewska

Krajewski

Matusiak

et al. 2023

JCM

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Introduction: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory dermatosis with vast psychosocial burden. The objective of this study is to thoroughly analyze satisfaction with life (SWL) and coping strategies of HS patients in relation to the clinical and psychosocial factors. Methods: 114 HS patients (53.1% females; mean age 36.6 ± 13.1 years) were enrolled. Severity of the disease was measured using Hurley staging and International HS Score System (IHS4). Instruments utilized: Satisfaction with Life Scale (SWLS); Coping-Orientation to Problems-Experienced Inventory (Brief COPE); HS Quality of Life Scale (HiSQoL); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); General Health Questionnaire (GHQ-28). Results: SWL was low in 31.6% of HS patients. No relation was found between SWL and Hurley staging and IHS4. SWL correlated with GHQ-28 (r = −0.579 p < 0.001), PHQ-9 (r = −0.603 p < 0.001), GAD-7 (r = −0.579 p < 0.001), and HiSQoL (r = −0.449 p < 0.001). Problem-focused coping strategies were most commonly used, followed by emotion-focused coping and avoiding coping strategies. Significant differences were found between the following coping strategies and SWL: self-distraction (p = 0.013), behavioral-disengagement (p = 0.001), denial (p = 0.003), venting (p = 0.019), and self-blame (p = 0.001). Conclusions: HS patients present low SWL which correlates with psychosocial burden. Reducing anxiety–depression comorbidity and encouraging optimal coping strategies may be of great importance in holistic approach to HS patients.

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“…In the course of the disease, hyperkeratosis and destruction of the hair follicles occur, and the involvement of apocrine sweat glands is a secondary phenomenon. The estimated prevalence of HS is 1%, with a predominance of women [ 18 , 19 ].…”

Section: The Aetiology and Pathogenesis Of Acnementioning

confidence: 99%

The Role of Skin Immune System in Acne

Firlej

Kowalska

Szymaszek

et al. 2022

JCM

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Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by Cutibacterium acnes, which promotes inflammation. Little is known about the role of skin immune cells in the development of acne lesions. The aim of the study was to try to understand the role of skin immune cells in the course of acne. Recent studies have shown that there are at least four major pathways by which Cutibacterium acnes interacts with the innate immune system to induce inflammation: through TLRs, activating inflammasomes, inducing the production of matrix metalloproteinases (MMPs), and stimulating antimicrobial peptide (AMP) activity. Cells of adaptive immune response, mainly Th1 and Th17 lymphocytes, also play an important role in the pathogenesis of acne. It is worth emphasizing that understanding the role of the skin’s immune cells in the pathogenesis of acne may, in the future, contribute to the application of modern therapeutic strategies that would avoid addiction to antibiotics, which would alleviate the spectrum of resistance that is now evident and a current threat.

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Indirect Self-Destructiveness in Hidradenitis Suppurativa Patients

Cited by 10 publications

References 16 publications

The Use of HSQoL-24 in an Assessment of Quality-of-Life Impairment among Hidradenitis Suppurativa Patients: First Look at Real-Life Data

The Use of HSQoL-24 in an Assessment of Quality-of-Life Impairment among Hidradenitis Suppurativa Patients: First Look at Real-Life Data

Satisfaction with Life and Coping Strategies among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study

The Role of Skin Immune System in Acne

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