Índice apo B/apo A-I e predição de risco cardiovascular

Lima, Luciana Moreira; Carvalho, Maria das Graças; Sousa, Marinez O.

doi:10.1590/s0066-782x2007000600014

Cited by 29 publications

(12 citation statements)

References 49 publications

(45 reference statements)

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“…Nowadays, the plasma levels of AI and B apolipoproteins are considered to be better predictors of atherosclerotic diseases than the concentrations of lipid and lipoprotein. It has been suggested that the Apo B/Apo AI index is a better standard for the prediction of cardiovascular risk than other lipid indices such as total cholesterol, LDL/HDL, and non-HDL/HDL cholesterol (Lima et al, 2007). In this study, it was observed that 48.8% of the population had altered Apo B/Apo AI indices, indicating a higher risk of CVD.…”

Section: Discussionmentioning

confidence: 58%

“…In the AMORIS study (Apolipoprotein-related Mortality Risk), about 170.000 patients were evaluated, and it was demonstrated that Apo B was a better indicator of cardiovascular risk than LDL cholesterol, especially in the individuals with desired levels of LDL cholesterol, regardless of gender. The Apo B/Apo AI index was identified in the AMORIS study as the single variable that was most related to the risk of fatal acute myocardial infarction (AMI), mainly when lipidemia was in the desired range (Lima et al, 2007). The overall prevalence of increased abdominal fat among the Kaingang (37.8%) was a little lower than in the Guarani-Mbyá (Cardoso et al, 2001; 44.5%) and Aruák 52.1%).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of metabolic syndrome among Kaingang native americans in southern Brazil

Anjos¹,

Toledo²,

Mota³

et al. 2011

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic syndrome among Kaingang native americans in southern Brazil

Anjos¹,

Toledo²,

Mota³

et al. 2011

Braz. arch. biol. technol.

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“…Plasma apolipoproteins A1 and B and the apo B/apo A1 ratio have been described as the best predictors of cardiovascular risk as compared with lipid and lipoprotein levels or the Castelli index I and II. 21 , 22 Apolipoproteins are structural and functional components of lipoproteins. Apo A1 constitutes non-atherogenic lipid fractions (HDL-c), whereas apo B constitutes atherogenic ones (chylomicrons, LDL, IDL and VLDL).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, apo B/apo A1 ratio represents the balance between atherogenic and antiatherogenic lipoproteins. 21 , 22 Increased apo B and apoB/A1 and reduced apo A1 levels have been consistently associated with risk for CVDs. 22 In our study group, 12.2% of women and 9.3% of men had an apo B/apo A1 ratio indicative of cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk in Xavante Indigenous Population

Soares¹,

Fabbro

Silva

et al. 2018

Arquivos Brasileiros De Cardiologia

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BackgroundThe prevalence of cardiovascular risk factors is little known in Brazilian indigenous populations. In the last two decades, important changes have occurred in the lifestyle and epidemiological profile of the Xavante people.Objectiveto assess the prevalence of cardiovascular risk factors in Xavante adults in São Marcos and Sangradouro/Volta Grande reserves, in the state of Mato Grosso, Brazil.MethodsCross-sectional study carried out with 925 Xavante people aged ≥ 20 years between 2008 and 2012. The following indicators were assessed: triglycerides (TG), total, LDL and HDL-cholesterol, Castelli index I and II, TG/HDL-cholesterol ratio, apo B / Apo A1 ratio, Framingham risk score, C-reactive protein, body mass index (BMI), waist circumference (WC), hypertriglyceridemic waist (HW), glycemia and blood pressure. Kolmogorov-Smirnov, Student's t test and Chi-square test (χ2) were used for statistical analysis, and significance level was set at 5%.ResultsHigh prevalence of elevated cardiovascular risk was observed in men and women according to HDL-cholesterol (66.2% and 86.2%, respectively), TG (53.2% and 51.5%), TG/HDL-cholesterol ratio (60.0% and 49.1%), C-reactive protein (44.1% and 48.1%), BMI (81.3% and 81.7%), WC (59.1% and 96.2%), HW (38.0% and 50,6%) and glycemia (46.8% and 70.2%). Individuals aged 40 to 59 years had the highest cardiovascular risk.ConclusionsThe Xavante have a high cardiovascular risk according to several indicators evaluated. The present analysis of cardiovascular risk factors provides support for the development of preventive measures and early treatment, in attempt to minimize the impact of cardiovascular diseases on this population.

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“…The apo B/ apo A-1 ratio represents the balance between potentially atherogenic cholesterol particles (apo B) and anti-atherogenic cholesterol particles (apo A-1). It has been suggested that this ratio represents a better predictor of atherosclerotic disease than lipid and lipoprotein concentrations 17,32 . The physiological function of Lp (a) is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure in Adolescence, Adipokines and Inflammation in Young Adults. The Rio de Janeiro Study

Campana¹,

Brandão²,

Pozzan³

et al. 2013

Arquivos Brasileiros De Cardiologia

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BackgroundThe impact of blood pressure (BP) during adolescence on other cardiovascular risk factors in young adults is important for the primary prevention. ObjectiveTo evaluate BP, anthropometric indexes, metabolic and inflammatory profiles in young individuals stratified by their BP behavior recorded for 18 years. MethodsA total of 116 individuals, of whom 63 were males, from the Rio de Janeiro study (follow-up of 17.76 ± 1.63 years), were assessed at two moments: A1 (12.40 ± 1.49 years) and A2 (30.09 ± 2.01 years). The 116 individuals were divided into two groups: GN (n = 71), of participants with normal BP at A1; and GH (n = 45), of those with abnormal BP at A1. BP, weight, height and body mass index (BMI) were measured at A1 and A2. At A2, abdominal circumference (AC) and laboratory, metabolic and inflammatory variables were included. Results1) No difference was observed between the groups as regards age and gender; 2) At A2, GH showed higher mean weight, BMI, BP, insulin, HOMA-IR (p < 0.001), leptin (p < 0.02), apolipoprotein B100 and A1 (p < 0.02), apolipoprotein B100 / apolipoprotein A1 ratio (p < 0.010); and higher prevalences of overweight/obesity (p < 0.001), of increased AC (p < 0.001) and of hypertension (p < 0.02); 3) No difference was observed between the groups as regards the inflammatory variables; 4) There was a positive correlation of BP at A1 with BP, BMI, insulin, leptin and HOMA-IR at A2 (p < 0.05). ConclusionBP in adolescence was associated with higher values of BP, and anthropometric and metabolic variables in young adulthood, but not with inflammatory variables.

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Índice apo B/apo A-I e predição de risco cardiovascular

Cited by 29 publications

References 49 publications

Prevalence of metabolic syndrome among Kaingang native americans in southern Brazil

Prevalence of metabolic syndrome among Kaingang native americans in southern Brazil

Cardiovascular Risk in Xavante Indigenous Population

Blood Pressure in Adolescence, Adipokines and Inflammation in Young Adults. The Rio de Janeiro Study

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