Indicators of phagocytic activity, autosensibilization and purine metabolism in patients with pneumoconiosis

Боєва, С С; Raksha-Slіusareva, O.A.; Slіusarev, O.A.

doi:10.14739/2310-1210.2018.4.135362

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…In coal miners of Ukraine, disorders were established that indicated the mechanism of pneumoconiosis development associated with changes in purine metabolism, with an increase of xanthine oxidase activity and the level of uric acid in the blood serum and subsequent incidence of autoimmune reactions against the background of the nonspecific resistance system disorders [20]. A study by Japanese scientists noted that men with hypouricemia and daily physical overload were at higher risk of cardiovascular morbidity and urinary system disorders [21].…”

Section: Discussionmentioning

confidence: 99%

Assessment Of Purine Catabolism And Morbidity In Miners Depending On Their Work Experience

Shaukhat,

Ibrayeva,

Rybalkina

et al. 2024

Russ Open Med J

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Objective — The role of end products of purine metabolism as predictors of the development of pathological changes and diseases caused by the impact of dust on the human body in a professional environment vs. the work experience (duration of underground experience in the field). Material and Methods — We analyzed the content of the end products of purine metabolism in the blood plasma of coal miners depending on the length of working in dusty conditions and evaluated the morbidity in the studied individuals via an analysis of the biomarkers. Results — The median levels of xanthine and uric acid exhibited similar significant trends with a decrease in values with underground work experience under 3 years and an increase in values with 5 or more years of experience. When assessing outcomes 1-3 years after the selection of coal miners into the study, we revealed that both acute diseases (acute respiratory viral infection (ARVI), COVID-19, acute bronchitis, and community-acquired pneumonia) and chronic diseases were present in all groups. One coal miner (2.9%) from the group with 7-10 years of underground work experience was diagnosed with an occupational disease. The development of radiological changes in the chest organs (pulmonary fibrosis, symptoms of chronic bronchitis) was detected in the groups with an experience of up to 3 years, 3-5 years, 5-7 years, and 7-10 years in 6.4%, 9.4%, 11.1%, and 5.8% of miners, respectively. Conclusion — According to logistic regression data, underground experience of 7-10 years has led to the reduction in the levels of xanthine and uric acid in the blood, which inflicted a statistically significant effect on the development of diseases in miners. Long-term underground work yielded 8.6-fold increase in the risk of developing diseases in miners.

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Section: Discussionmentioning

confidence: 99%

Assessment Of Purine Catabolism And Morbidity In Miners Depending On Their Work Experience

Shaukhat,

Ibrayeva,

Rybalkina

et al. 2024

Russ Open Med J

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“…The number of monocytes in peripheral blood does not change significantly with age, age-related changes are mainly related to macrophage activity, however, there is evidence of phagocytosis inhibition in monocytes and the production of reactive oxygen (Plowden et al, 2004;Hearps et al, 2012;Metcalf et al, 2015). In general, when exposed to extreme exogenous factors, phagocytic activity is indicated among the sensitive factors of innate immunity (Skivka et al, 2015a;Boieva et al, 2018). The age-related changes in the number and function of NK cells, which are considered to be short-lived effector cells, are quite controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Accelerated aging and increased susceptibility to chronic diseases are facilitated by living in ecologically unfavourable regions and stresses of various nature. Moreover, the positive effects of the achievements of modern medicine can be largely smoothed over (Rajah et al, 2009;Boieva et al, 2018). Recently, a wide range of age-related diseases, including cardiovascular and cancer, have been described for exposed groups of people.…”

Section: Introductionmentioning

confidence: 99%

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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We studied the features of allostatic load (AL) in 100 students aged 18–24 years old who, from birth to adulthood, lived in the territories assigned to the IV radiation zone after the Chornobyl accident (density of soil contamination by isotopes 137Cs 3.7–18.5∙104 Bq/m2) and underwent prolonged exposure to small doses of ionizing radiation. The examined students did not have any clinical signs of the immune-neuroendocrine system dysfunction. 50 people had signs of vegetative-vascular dystonia syndrome (VVD), 48 had signs of moderate hyperthyroidism and 21 had signs of moderate hypothyroidism. During the examination session, as a factor of additional psycho-emotional load, in 66 of the examined the immunoregulatory index CD4+/CD8+ went below the lower limit of the homeostatic norm, in 62 of the examined low density lipoprotein cholesterol (LDL-C) exceeded the upper level. The relative risk (RR) and attributable risk (AR) of the participation of potential secondary factors of allostatic load formation in CD4+/CD8+ immunoregulatory index going below the lower limit were calculated. The presence of statistically significant relative risk of participation in the formation of suppression of the index CD4+/CD8+: the state of hyperthyroidism, state of hypothyroidism, vegetative-vascular dystonia syndrome, higher than normal LDL-C. When the examined students combined the signs of hyperthyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C; with combination of signs of hypothyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C. The attributable risk in all cases exceeded 0.10, which confirmed the importance of some of these factors and their complexes in the formation of the effect of reduced immunoregulatory index. The CD4+/CD8+ index can be considered an important biomarker of AL and premature age-related changes in the immune system in residents of radiation-contaminated areas. The risk of AL formation in the case of occurrence of a complex of mediated secondary biomarkers (vegetative-vascular dystonia syndrome, thyroid dysfunction, hypercholesterolemia) is higher compared to their individual significance.

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Indicators of phagocytic activity, autosensibilization and purine metabolism in patients with pneumoconiosis

Cited by 2 publications

References 4 publications

Assessment Of Purine Catabolism And Morbidity In Miners Depending On Their Work Experience

Assessment Of Purine Catabolism And Morbidity In Miners Depending On Their Work Experience

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

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