Indicators of antioxidant protection of blood in necrotizing ulcerative gingivitis in experimental animals

Kilmukhametova, Yuliia H.; Батиг, В. М.; Ostafiichuk, Marianna Alexandrovna; Tokar, Olha Mykhaylivna; Glushchenko, Tatiana Anatoliyivna; Batih, Iryna Viktorivna; Шеремет, М. І.

doi:10.25122/jml-2020-0149

Cited by 4 publications

(4 citation statements)

References 26 publications

(13 reference statements)

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“…Indeed, excessive lipoperoxidation damages cell membranes and intracellular organelles, impairing cell metabolism. Hence, the accumulation of toxic metabolites not only affects periodontal tissues, but also leads to significant metabolic disorders in the entire body [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Cristo¹,

Valentino²,

Luca³

et al. 2022

Molecules

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The management of periodontitis remains a vital clinical challenge due to the interplay between the microorganisms of the dental biofilm and the host inflammatory response leading to a degenerative process in the surrounding tissues. Quercetin (QUE), a natural flavonol found in many foods, including apples, onions and tea, has exhibited prolonged and strong antibiofilm and anti-inflammatory effects both in vitro and in vivo. However, its clinical application is limited by its poor stability and water solubility, as well as its low bioavailability. Thus, in the present study, electrospun polylactic acid (PLA) nanofibers loaded with different amounts (5–10% w/w) of QUE were produced to rapidly respond to the acidic microenvironment typical of periodontal pockets during periodontal disease. This strategy demonstrated that PLA-QUE membranes can act as a drug reservoir releasing high QUE concentrations in the presence of oral bacterial infection (pH < 5.5), and thus limiting Pseudomonas aeruginosa PAO1 and Streptococcus mutans biofilm maturation. In addition, released QUE exerts antioxidant and anti-inflammatory effects on P. gingivalis Lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGFs). The reported results confirmed that PLA-QUE membranes could inhibit subgingival biofilm maturation while reducing interleukin release, thereby limiting host inflammatory response. Overall, this study provided an effective pH-sensitive drug delivery system as a promising strategy for treating periodontitis.

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Section: Resultsmentioning

confidence: 99%

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Cristo¹,

Valentino²,

Luca³

et al. 2022

Molecules

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“…Despite the desire to reduce antibiotics in dental infections, antibiotics are effective in the treatment of the following dental infections: acute necrotizing ulcerative gingivitis, stage III grade C/incisor-molar pattern periodontitis, acute periapical abscess, cellulitis, local or systemic spread infection, pericoronitis, peri-implantitis, deep facial layers of the head and neck infection, Ludwig angina, anaerobic infections. [53] Amoxicillin is a broad-spectrum penicillin that is destroyed by bacterial penicillin. It treats dental caries, gingivitis, periapical abscesses, pericoronitis, endodontitis, and pulpitis with apical abscesses.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, there is antagonism between clindamycin and metronidazole as only 1 study was done by researchers, [53] but most researchers, such as, [53] used clindamycin with metronidazole to prevent dry socket and pseudomembranous colitis at the same time (prevent the side effect).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial management of dental infections: Updated review

Abdullah,

Hatim,

Oraibi

et al. 2024

Medicine

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Dental infections, which include anything from severe periodontal illnesses and abscess forms to routine tooth caries, are a major public health risk. This review article focuses on the pathophysiology and treatment of dental infections. A narrative review was conducted based on several published articles, relevant journals, and books in Google Scholar PubMed using the keywords dental caries, periodontal disease, gingivitis, and related diseases; we excluded duplicated information. Our review illustrated the types of dental infections and the proper antimicrobial drug that is suitable for this disease. Drawing from recent research findings and clinical evidence, we explore the spectrum of bacteria commonly associated with dental infections and their susceptibility profiles to various antibiotics. Emphasis is placed on understanding the mechanisms of antibiotic action and resistance in the context of dental pathogens, shedding light on optimal treatment regimens and potential challenges in clinical management. Additionally, we go over the clinical consequences of antibiotic therapy in dentistry, taking into account factors like patient selection, dose guidelines, and side effects. The management of dental infections through antimicrobial strategies has undergone significant advancements, as evidenced by this updated review. Besides the normal methods, emerging technologies such as 3D printing for drug delivery of antibiotics and disinfectants hold promise in enhancing treatment efficacy and patient outcomes. By leveraging the precision and customization afforded by 3D printing, dentistry can tailor antimicrobial interventions to individual patient needs, optimizing therapeutic outcomes while minimizing adverse effects.

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“…LPO products damage cell membranes and intracellular organelles, which is then accompanied by destructive tissue changes, hyperenzymemia and accumulation of toxic substances. Thus, the periodontium becomes a center of formation of toxic metabolites, in excess concentrations of which not only have a toxic effect on periodontal tissues, impairing cell metabolism, but also provoke significant disorders of metabolic processes in the body (Narendra et al 2018;Kilmukhametova et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Effects of flavonol quercetin on syndrome of endogenous intoxication in experimental periodontitis

Demkovych¹,

Shcherba²,

Yaremchuk³

et al. 2021

PHAR

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The article presents the results of study effect of quercetin on the indicators of endogenous intoxication syndrome under conditions of experimental periodontitis. One of the key links in the pathogenesis of any inflammatory disease, including maxillofacial area, is endogenous intoxication, an important pathophysiological mechanism of which is the activation of lipid peroxidation. The experimental animals were treated by intramuscular injections with water-soluble quercetin for 7 days. For further research the blood serum was selected in which was determined the content of middle molecular weight molecules and erythrocyte intoxication index. Excessive lipoperoxidation was accompanied by accumulation of peroxidation products and depletion of antioxidant reserves, which led to accumulation of toxic substances. That is why the study of the level of middle molecular weight molecules and erythrocyte intoxication index in simulated bacterial-immune periodontitis is a reliable criterion. Quercetin was able to reduce the expression of endogenous intoxication syndrome in experimental bacterial-immune periodontitis.

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Indicators of antioxidant protection of blood in necrotizing ulcerative gingivitis in experimental animals

Cited by 4 publications

References 26 publications

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment

Antimicrobial management of dental infections: Updated review

Effects of flavonol quercetin on syndrome of endogenous intoxication in experimental periodontitis

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