Indications for Preoperative
Seminal Vesicle Biopsies in Staging
of Clinically Localized Prostatic
Cancer

Guillonneau, Bertrand; Debras, Bertrand; Veillon, B; Bougaran, J; Chambon, Emmanuel; Vallancien, Guy

doi:10.1159/000480851

Cited by 41 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 The data of Bertrand et al on the basal cores showed that SVI had been seen in 0% (0/21), 10.3% (4/ 39) and 73.3% (11/15) of the patients with none, one of the two, or both basal biopsy cores involved by cancer among patients with clinically localized prostatic cancer. 18 Other reports as well as our study have revealed the importance of the basal cores at prostate biopsy for detection of SVI. 16,18 Zlotta et al concluded that for patients with serum PSA <10 ng/mL, the probability of SVI remains at <5%.…”

Section: Discussionsupporting

confidence: 62%

“…18 Other reports as well as our study have revealed the importance of the basal cores at prostate biopsy for detection of SVI. 16,18 Zlotta et al concluded that for patients with serum PSA <10 ng/mL, the probability of SVI remains at <5%. 17 This however, excludes the patients with Gleason score on biopsy of 7 or greater or the patients with more than 50% of biopsy cores involved.…”

Section: Discussionsupporting

confidence: 62%

“…Although less PSA indicates a better outcome in general, some arguments still remain about the preoperative predictive value of PSA. 18,22 In our study, the patients were divided into three groups according to their serum PSA levels. In group 1 (PSA <10 ng/mL), significant differences were found between positive and negative SVI on univariate analysis for clinical stage, tumor differentiation of biopsy and percentage of positive cores by biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…21 Some authors have performed seminal vesicle biopsies. 18,[30][31][32] According to Linzer et al 14% of clinically localized prostate cancer patients (27/187) had positive SVI detected by seminal vesicle biopsy before radical prostatectomy and final pathological evaluation revealed the same result. 31 However, Deliveliotis et al, who reported on 100 seminal vesicle biopsies prior to 50 radical prostatectomies for clinical stages under T2, found that 87 of 100 biopsy specimens were identified as seminal vesicle and cancer was found in seven (8%) and confirmed in all cases by the surgical specimen.…”

Section: Discussionmentioning

confidence: 99%

“…The following have been considered as predictors of SVI: clinical stage, PSA, tumor differentiation or Gleason score, percentage of cancer positive cores and basal cores involvement. [15][16][17][18][19][20][21] However, whether PSA is a good predictor remains controversial. 18,22 Considering such a background, the aim of this study was to analyze clinical data in an effort to find parameters that could predict SVI before radical prostatectomy.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Predictors of seminal vesicle invasion before radical prostatectomy

Tsurumaki¹,

Tomita²,

Kume³

et al. 2006

Int J of Urology

View full text Add to dashboard Cite

Aim:To predict whether or not seminal vesicle invasion is present before radical prostatectomy, the relationships between clinical parameters and seminal vesicle invasion were analyzed. Methods: A review was conducted of 187 patients who had been clinically diagnosed with stages A 2 , B 0 , B 1 , B 2 or C prostate cancer and who had undergone radical prostatectomy without neoadjuvant therapy. The parameters analyzed for potential predictors of seminal vesicle invasion before radical prostatectomy included age, clinical stage, serum prostate-specific antigen (PSA) level at biopsy, tumor differentiation of biopsy specimens and percentage of cancer positive cores by biopsy. For percentage of cancer positive cores by biopsy, 143 of 187 patients who underwent transrectal sextant biopsy or more than six transrectal ultrasound guided core biopsies were evaluated. These parameters were subjected to univariate and multivariate logistic regression analyses to identify predictors for seminal vesicle invasion. Results: The median age was 66.8 years (range 51-77 years). Of 187 patients, 27 (14.4%) had seminal vesicle invasion confirmed pathologically. There were significant differences in all parameters except for age between patients with positive and negative seminal vesicle invasion on univariate analysis. Multivariate analysis revealed that serum PSA level, tumor differentiation of biopsy specimens and percentage of cancer positive cores were significant independent predictors of seminal vesicle invasion. Conclusions: The results showed serum PSA level, tumor differentiation of biopsy specimens and percentage of cancer positive cores by biopsy before radical prostatectomy may be useful predictors for seminal vesicle invasion.

show abstract