Indications for local resection for gastric leiomyosarcoma

Katai, Hitoshi; Sasako, Mitsuru; Sano, Toshikazu; Okajima, Keiichiro; Maruyama, Koshi; Ochiai, Atsushi

doi:10.1016/0016-5085(95)26266-0

Cited by 6 publications

(12 citation statements)

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“…At the National Cancer Centre Hospital (NCCH), Tokyo, Japan, from 1982 wedge resection was done if technically possible without a requirement for systemic nodal dissection, because, according to the recent literature, 5 the type of surgery had no impact on the patient's prognosis. We reviewed 177 cases of GISTs of the stomach diagnosed and treated at NCCH between 1962 and 2003, two (1.1%) of which were found intraoperatively to have metastasized into the lymph nodes (LNs), the clinicopathological and molecular findings of which we examined.…”

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confidence: 99%

Gastrointestinal stromal tumour of the stomach showing lymph node metastases

et al. 2005

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confidence: 99%

Gastrointestinal stromal tumour of the stomach showing lymph node metastases

et al. 2005

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“…They also reported that 100% of their patients with an LMS Ͻ 5 cm were alive after 5 years. Koga et al [55] stated that distant metastasis, adjacent invasion, high mitotic rates, and severe nuclear atypia conferred an unfavorable prognosis on patients with LMS; 5-year survival rate for tumors Ͻ 6cm with more than four mitoses per 20 high-power fields (HPF) was 20% among 83 patients [55].…”

Section: Mortality and Prognosismentioning

confidence: 99%

Tumors of the Stomach

et al. 2000

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This collective review includes all available case reports of smooth muscle (stromal) tumors of the stomach in the world literature from 1762 to 1996. It updates our previous review from 1767 to 1959. Overall, we identified 2189 patients with leiomyoma (LM) and 1594 with leiomyosarcoma (LMS). The peak age of incidence of LM was 50 to 59 years, while LMS was most frequently seen between ages 60 and 69. Women were more likely to develop LM, and men more commonly presented with malignant smooth muscle tumors of the stomach. Concerning the patterns of growth, LMs were more likely to grow intraluminally (endogastric), whereas LMSs were predominantly exogastric. The most common site of LMs was on the anterior or posterior wall of the body of the stomach; LMSs were most likely found along the greater curve. The presenting symptoms of both types of smooth muscle tumors were similar; in decreasing order of frequency they were bleeding, pain, palpable mass, and weight loss. Interestingly, there was no correlation between the size of the tumor and signs or symptoms of bleeding, pain, weight loss, or ulceration, although patients with LMSs were more likely to report weight loss than patients with benign tumors. For LMS, there seemed to be no correlation between tumor size or location and rate of metastasis, although the tumors that grew in a dumbbell shape (i.e., both intraluminally and extraluminally) had a higher frequency of metastasis than other growth patterns. Overall, the rate of metastasis at diagnosis was 35.4%, with the liver, spleen, and regional lymph nodes the most common sites.

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“…The tumor may present with a pseudocapsule and should be removed en bloc without a wide resection margin. Regional lymphadenectomy should be avoided since GISTs seldom spread to the lymph nodes [12][13][14] . There are no data to support the use of radiotherapy, and no effective chemotherapy for GISTs existed until the introduction of imatinib mesylate, a potent inhibitor of two cell-surface protein tyrosine kinases, the platelet-derived growth factor receptor and the stemcell factor receptor (c-kit).…”

Section: Introductionmentioning

confidence: 99%

“…Local peritoneal tumor seeding is common, and a local peritonectomy should be performed if possible. Regional lymphadenectomy should be avoided since GISTs seldom spread to lymph nodes 13,14 . Tumor rupture, spontaneously or during surgery, may be associated with an increased risk of development of peritoneal implants and should be avoided 36 .…”

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Clinical Presentation and Treatment of Gastrointestinal Stromal Tumors

Cipolla

Fulfaro

Sandonato

et al. 2006

Tumori

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Results:The patients with localized disease treated only by surgery did not relapse. In the patients with locally advanced or metastatic disease treated by imatinib, we observed 3 partial responses, and one case was not assessable because he had no measurable disease. In 2 of 3 responders, it was possible to perform a new radical surgery. Conclusions: Our series is too small to draw any conclusion. According to our review of the literature, surgery remains the standard treatment for non-metastatic GISTs. Imatinib mesylate represents a major breakthrough in the treatment of advanced GISTs and is the first effective systemic therapy for the disease.

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Indications for local resection for gastric leiomyosarcoma

Cited by 6 publications

References 0 publications

Gastrointestinal stromal tumour of the stomach showing lymph node metastases

Gastrointestinal stromal tumour of the stomach showing lymph node metastases

Tumors of the Stomach

Clinical Presentation and Treatment of Gastrointestinal Stromal Tumors

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