Indications for bone marrow examinations in rheumatology

Teke, Hava Üsküdar; Korkmaz, Cengiz

doi:10.1007/s00296-019-04312-w

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Inclusion criteria were: (1) a standardized completed contrast-enhanced DECT exam, (2) no known rheumatological, hematooncological or metastatic tumor disease, (3) no vertebral body insufficiency fractures, and (4) no pronounced scoliosis. Exclusion criteria were: (1) a history of systemic anti-cancer treatment and (2) any hematooncological [ 16 ], metastatic tumor [ 17 ] or rheumatological [ 18 ] disease known to affect the bone or bone marrow (see Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

Dual-Energy Computed Tomography-Based Quantitative Bone Marrow Imaging in Non-Hematooncological Subjects: Associations with Age, Gender and Other Variables

Hagen

Fritz

Mair

et al. 2022

JCM

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Background: Our aim is to assess the utility and associations of quantitative bone marrow attenuation (BMA) values measured on clinical dual-energy computed tomography (DECT) exams in non-hematooncologic subjects with skeletal regions, patient age, gender, and other clinical variables. Methods: Our local ethics committee approved this retrospective image data analysis. Between July 2019 and July 2021, 332 eligible patients (mean age, 64 ± 18 years; female, 135) were identified. Inclusion criteria were the availability of a standardized abdominopelvic DECT data set acquired on the same scanner with identical protocol. Eleven regions-of-interest were placed in the T11-L5 vertebral bodies, dorsal iliac crests, and femur necks. Patient age, gender, weight, clinical, habitual variables, inflammation markers, and anemia were documented in all cases. Results: Multi-regression analyses (all, p < 0.05) identified age as the strongest predictor of lumbar BMA (standardized coefficient: β = −0.74), followed by CRP (β = 0.11), LDH (β = 0.11), and gender (β = −0.10). In the lower thoracic spine, age was the strongest predictor (β = −0.58) of BMA, followed by gender (β = −0.09) and LDH (β = 0.12). In femoral bones, age was negatively predictive of BMA (β = −0.12), whereas LDH and anemia were positively predictive (β = 0.16 both). Heart insufficiency significantly decreased (β = 0.12, p = 0.034) a BMA value gradient from higher to lower HU values along the vertebrae T11 and L5, whereas age significantly increased this gradient (β = −0.2, p ≤ 0.001). Conclusions: DECT-based BMA measurements can be obtained from clinical CT exams. BMA values are negatively associated with patient age and influenced by gender, anemia, and inflammatory markers.

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Section: Methodsmentioning

confidence: 99%