Bone marrow biopsy diagnostic yield in internal medicine

Martellosio, Jean-Philippe; Puyade, Mathieu; Debiais, C.; Elsendoorn, A.; Souchaud-Debouverie, O.; Landron, C.; Luca, L. De; Roy-Péaud, F.; Milin, Serge; Roblot, P.; Martin, M.

doi:10.1080/00325481.2020.1835118

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…Given that it was the aspirate culture that guided appropriate therapy, an earlier BMAT may have resulted in earlier treatment and potentially a better outcome for the patient, however it is important to appreciate the limitations of BM investigations. BM trephine biopsy has a 14–31.9% yield as a diagnosis-defining investigation [9] , [10] , however, aspirate cultures have mixed yields ranging from 0–40% [10] , [11] and are not typically considered a common investigation for fevers. Blood and urine cultures have a higher diagnostic yield than BM culture when investigating for fevers [10] .…”

Section: Discussionmentioning

confidence: 99%

“…BM trephine biopsy has a 14–31.9% yield as a diagnosis-defining investigation [9] , [10] , however, aspirate cultures have mixed yields ranging from 0–40% [10] , [11] and are not typically considered a common investigation for fevers. Blood and urine cultures have a higher diagnostic yield than BM culture when investigating for fevers [10] . There are however some reports that BM aspirate culture slightly enhances diagnosis in immunocompetent patients [12] , by up to 5.5% [10] .…”

Section: Discussionmentioning

confidence: 99%

“…Blood and urine cultures have a higher diagnostic yield than BM culture when investigating for fevers [10] . There are however some reports that BM aspirate culture slightly enhances diagnosis in immunocompetent patients [12] , by up to 5.5% [10] . It is worth noting that BM culture has a higher sensitivity for detecting fungal pathogens in comparison to a BM stain and microscopy, and that detecting a fungus on a BM trephine stain in an immunocompetent patient is generally rare [13] .…”

Section: Discussionmentioning

confidence: 99%

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Candida parapsilosis bone marrow infection in an immunocompetent patient

Edwards,

La,

Abasszade

et al. 2024

IDCases

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Candida parapsilosis bone marrow infection in an immunocompetent patient

Edwards,

La,

Abasszade

et al. 2024

IDCases

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“…Studies of lymphoma patients have shown that about 40% of ML patients have lesions that infiltrate the bone marrow. However, the exact diagnosis of BMI in patients with ML usually requires bone marrow biopsy, which can increase the risk of local infection, bleeding, bone marrow necrosis, and other invasive tests [ 18 , 19 ]. Thus, establishing a BMI prediction model based on the laboratory indicators of ML patients at initial diagnosis has important guiding significance for clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Prediction Model of Bone Marrow Infiltration in Patients with Malignant Lymphoma Based on Logistic Regression and XGBoost Algorithm

Huang

Chen

Miao

2022

Computational and Mathematical Methods in Medicine

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Objective. The prediction model of bone marrow infiltration (BMI) in patients with malignant lymphoma (ML) was established based on the logistic regression and the XGBoost algorithm. The model’s prediction efficiency was evaluated. Methods. A total of 120 patients diagnosed with ML in the department of hematology from January 2018 to January 2021 were retrospectively selected. The training set ( n = 84 ) and test set ( n = 36 ) were randomly divided into 7 : 3, and logistic regression and XGBoost algorithm models were constructed using the training set data. Predictors of BMI were screened based on laboratory indicators, and the model’s efficacy was evaluated using test set data. Results. The prediction algorithm model’s top three essential characteristics are the blood platelet count, soluble interleukin-2 receptor, and non-Hodgkin’s lymphoma. The area under the curve of the logistic regression model for predicting the BMI of patients with ML was 0.843 (95% CI: 0.761~0.926). The area under the curve of the XGBoost model is 0.844 (95% CI: 0.765~0.937). Conclusion. The prediction model constructed in this study based on logistic regression and XGBoost algorithm has a good prediction model. The results showed that blood platelet count and soluble interleukin-2 receptor were good predictors of BMI in ML patients.

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Patient Satisfaction Experience and Outcomes after CT-Guided Bone Marrow Biopsy Versus In-Office Bone Marrow Biopsy

Srivastava,

Pezeshk,

Chhabra

2024

Radiation

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Aim: To evaluate patient satisfaction outcomes with respect to pain, discomfort, and quality of life with hematology/oncology referrals undergoing CT-guided bone marrow biopsy and compare these scores with those of patients undergoing in-office biopsy. Methods: A retrospective chart review was performed over 2 years with all patients who underwent CT-guided bone marrow biopsy at our university set-up. Age, gender, BMI, radiation dose (CTDI/DLP), number of in-office biopsies, number of CT-guided biopsies, type/amount of moderate sedation used, technical and pathologic success rates, and complication rates were recorded. All patients who underwent both in-office and CT-guided biopsy were contacted by telephone to answer a brief survey regarding pain, discomfort, quality of life, and future preference with respect to each biopsy. Results: A total of 32 patients underwent CT-guided bone marrow biopsy. Moderate sedation was utilized for all CT patients, and 19 patients underwent both in-office and CT-guided biopsies. Upon surveying the 19 patients who underwent both kinds of biopsies, on a scale of 1–10 (10 = highest discomfort and highest pain), the patients on an average reported 7.8 for in-office vs. 2.1 for CT for the discomfort level (p < 0.001) and 7.9 vs. 1.7 for the pain (p < 0.001). The patients reported an average quality-of-life score of 82 (out of a scale of 100) after CT procedures and 53 for in-office (p < 0.001). All patients reported that they would prefer CT-guided procedures with sedation versus in-office procedures in the future. Conclusion: CT-guided bone marrow biopsy is the preferred and more comfortable procedure, especially in low-pain-tolerant patients, although it involves more cost, conscious sedation, and radiation exposure.

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Bone marrow biopsy diagnostic yield in internal medicine

Cited by 3 publications

References 21 publications

Candida parapsilosis bone marrow infection in an immunocompetent patient

Candida parapsilosis bone marrow infection in an immunocompetent patient

Prediction Model of Bone Marrow Infiltration in Patients with Malignant Lymphoma Based on Logistic Regression and XGBoost Algorithm

Patient Satisfaction Experience and Outcomes after CT-Guided Bone Marrow Biopsy Versus In-Office Bone Marrow Biopsy

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