Indian Herbal Remedies

Khare, C.P.

doi:10.1007/978-3-642-18659-2

Cited by 164 publications

(5 citation statements)

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“…One ethnomedical practice reported from the Paliyar tribe from Tamilnadu in India involves taking internally, dried fruit coat of P. granatum after grinding and mixing with water, to treat stomach ache and diarrhoea ( Duraipandiyan et al, 2006). Ayurvedic pharmacopeia of India mentions formulations containing rind of P. granatum to be useful in conditions such as fever, dysentery, bacteremia, and infections of oral cavity ( Khare, 2004). Decoction containing P. granatum peel is used for gastrointestinal benefit in Algeria too ( Gharzouli et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

2019

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Background: Punica granatum extracts have been prescribed in traditional medicine for management of a variety of disease conditions including microbial infections. Generation of scientific evidence for validation of P. granatum peel extract’s anti-pathogenic efficacy is required. Methods: Hydroalcoholic extract of P. granatum peel (PGPE), prepared by microwave assisted extraction method was evaluated for its quorum-modulatory potential against two different human-pathogenic bacteria viz. Chromobacterium violaceum and Pseudomonas aeruginosa. Results: This extract was able to modulate in vitro production of quorum sensing-regulated pigments in both these test bacteria at ≥5 μg/ml. Virulence traits of P. aeruginosa like haemolytic activity, and biofilm formation were negatively affected by the test extract, and it also made P. aeruginosa more susceptible to lysis by human serum. Antibiotic susceptibility of both test bacteria was modulated owing to pre-treatment with PGPE. Exposure of these test pathogens to PGPE (≥0.5 μg/ml) effectively reduced their virulence towards the nematode Caenorhabditis elegans. Repeated subculturing of P. aeruginosa on PGPE-supplemented growth medium did not induce resistance to PGPE in this notorious pathogen, and this extract was also found to exert a post-extract effect on P. aeruginosa. Individual constituent phytocompounds of PGPE were found to be less efficacious than the whole extract. PGPE seemed to interfere with the signal-response machinery of P. aeruginosa and C. violaceum. PGPE also exhibited notable prebiotic potential by promoting growth of probiotic strains- Bifidobacterium bifidum and Lactobacillus plantarum at ≤50 μg/ml. Conclusions: This study indicates PGPE to be an effective antipathogenic and prebiotic preparation, and validates its therapeutic use mentioned in traditional medicine. This study also emphasizes the need for testing any bioactive extract at broadest possible concentration range, particularly in vivo, so that an accurate picture of dose-response relationship can emerge.

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Section: Introductionmentioning

confidence: 99%

Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

2019

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“…Moreover, the essential oils from P. angustifolium were effective against Leishmania infantum ( 75 ). Also P. cubeba exhibited anthelmintic activity against earthworms and tapeworms in vitro ( 76 ).…”

Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Cubeb (Piper cubeba L.f.): A comprehensive review of its botany, phytochemistry, traditional uses, and pharmacological properties

et al. 2022

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Piper cubeba L.f. (Piperaceae), known as cubeb, is a popular traditional herbal medicine used for the treatment of many diseases, especially digestive and respiratory disorders. The plant is rich in essential oil, found mainly in fruits, and this makes it economically important. Many traditional utilizations have been also validated from the plant and its isolated compounds owing to their antioxidant, antibacterial, anti-inflammatory and anticancer effects. These biological activities are attributed to the phytochemicals (phenolic compounds, lignans and alkaloids) and the essential oil of the plant. The present work aims to provide an up-to-date review on the traditional uses, phytochemistry and pharmacology of the plant and discusses the future perspectives to promote its valorization for nutritional- and health-promoting effects.

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“…Nelumbo nucifera Gaertn, also known as Indian lotus, Chinese water lily, sacred lotus, India bean, Egyptian bean, or simply lotus, is currently classified as a single genus of Nelumbonaceae (Shen-Miller et al, 2002). Embryo of lotus seed, as an ancient folk herb, is widely used to overcome nervous disorders, insomnia, high fever (with restlessness), and cardiovascular diseases (SATCM, 1999; Khare, 2004; China Pharmacopoeia Committee, 2015). Previous studies have shown that isoquinoline alkaloids were the active components in the bitter embryos (Zhang and P, 2002; Itoh et al, 2011; Li et al, 2016; Sharma et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

ITRAQ-Based Proteomics Analysis Reveals the Effect of Neoliensinine on KCl-Induced Vascular Smooth Muscle Contraction by Inhibiting Regulatory Light Chain Phosphorylation

Yang

Wang

et al. 2019

Front. Pharmacol.

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Smooth muscle (SM) contraction is one of the important physiological functions of the human body, and SM abnormal contraction will induce many diseases. The phosphorylated regulatory light chains (p-RLC) play a decisive role in SM contraction, and dephosphorylation of p-RLC is an effective way to relax SM. Our previous study showed that the novel benzylisoquinoline alkaloid, neoliensinine (Neo), could relax microvascular SM contracted by KCl hyperpolarization. In this study, mesenteric capillaries isolated from 45 mice were divided into normal tension group (Control), 124 mM KCl induced contraction model group (Model), and KCl and Neo-treatment group (Drug). The dephosphorylation levels of RLC in the three groups were measured. Compared with the model group, the phosphorylation of RLC in the drug group was decreased dramatically as expected, suggesting that the relaxation effect of Neo was caused by downregulating p-RLC of microvessel SM. In order to fully understand its fundamental mechanism, our research focused on the identification of target proteins in mice with KCl-induced contractile mesenteric capillary. Isobaric tags for relative and absolute quantification (ITRAQ) tagging was carried out by nanospray liquid chromatography–tandem mass spectrometry. The results allowed the upregulation of 164 differential abundance proteins (DAPs) among the 3,474 protein abundance disturbances identified from the model/control samples. Further comparison showed that there were 16 DAP convergences associated with vascular SM contraction between the drug/model and the drug/control samples. Among them, two proteins with known function, PLCβ and RhoGEF12, were selected as target proteins of the relaxation effect of Neo. The two selective target DAPs were verified by Western blot at protein level. The results suggested that changes of the two proteins were consistent with that of the iTRAQ results. Our present work reveals that Neo relaxes vascular smooth muscle via inhibition of RLC phosphorylation, and PLCβ and RhoGEF12 may be potential biomarkers for evaluating the effects mediated by Neo.

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Indian Herbal Remedies

Cited by 164 publications

References 0 publications

Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens

Cubeb (Piper cubeba L.f.): A comprehensive review of its botany, phytochemistry, traditional uses, and pharmacological properties

ITRAQ-Based Proteomics Analysis Reveals the Effect of Neoliensinine on KCl-Induced Vascular Smooth Muscle Contraction by Inhibiting Regulatory Light Chain Phosphorylation

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