Indexation of left ventricular mass in adults with a novel approximation for fat-free mass

Kuch, Bernhard; Gneiting, Birgit; Döring, Angela; Muscholl, M.; Bröckel, Ulrich; Schunkert, Heribert; Hense, Hans‐Werner

doi:10.1097/00004872-200101000-00018

Cited by 36 publications

(32 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Normalizing by CRL 2.7 and correcting for age, there were no significant gender-related differences. These findings support the results of human studies suggesting fat-free mass to optimally normalize LV mass [25]. …”

Section: Discussionsupporting

confidence: 90%

“…Fat-free mass has been proposed to be the best method of indexing LV mass to body size [25, 28, 29]. Height measures and BSA reflect lean body mass whereas BMI more closely reflects body fat.…”

Section: Discussionmentioning

confidence: 99%

“…Two-dimensional images were used when the scanning axis was not perpendicular to the axis of the heart; misalignment of the M-mode beam was noted in approximately 30% of cases. LV mass and LVEF were calculated by the American Society of Echocardiography-corrected cube formula [24] and indexed by BSA, CRL and CRL 2.7 [25]. Stroke volume (SV) and cardiac output (CO) were measured as previously reported [9].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques <i>(Macaca radiata)</i>

Lazar

Qureshi²,

Qureshi³

et al. 2008

Cardiology

View full text Add to dashboard Cite

Objectives: Macaques are used in cardiovascular and metabolic research. We determined echocardiographic-derived reference values of left ventricular (LV) systolic and diastolic function in healthy adult bonnet macaques (Macaca radiata). Methods: Transthoracic echocardiography was performed during ketamine sedation in 83 (67% female) healthy monkeys (age 7–26 years). Results: Technically adequate studies were obtained in all subjects and required 10.1 ± 1.3 min of scanning time. Age correlated inversely with the following Doppler indices: E (r = –0.44, p < 0.001), E/A (r = –0.26, p = 0.02), E′ (r = –0.45, p < 0.001, E′/A′ (r = –0.44, p < 0.001), E/E′ (r –0.25, p = 0.03), S′ (r = –0.33, p = 0.003), Vp (r = –0.26, p = 0.049). LV mass was more strongly correlated with crown rump length (r = 0.72, p < 0.001) and body surface area (r = 0.70, p < 0.001) than with body mass index (r = 0.47, p < 0.001) and weight (r = 0.63, p < 0.001). Conclusions: This study demonstrates echocardiography is feasible for characterizing LV function. Age-related changes in Doppler indices in primates are similar to those in humans. LV mass is more closely related to fat-free mass indices. We provide reference values for LV systolic and diastolic function in adult bonnet macaques across the captive life span.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques <i>(Macaca radiata)</i>

Lazar

Qureshi²,

Qureshi³

et al. 2008

Cardiology

View full text Add to dashboard Cite

show abstract

“…23 Thus, the third LVH criteria was based on LVM LBM Ͼ4.1 g/kg in men and women. 24 Hypertension was considered as a BP of Ն140/90 mm Hg, current intake of antihypertensive medication, or both. Body mass index was computed as weight divided by height squared (kg/m 2 ).…”

Section: Definitionsmentioning

confidence: 99%

Association of the Ghrelin Receptor Gene Region With Left Ventricular Hypertrophy in the General Population

et al. 2006

Self Cite

View full text Add to dashboard Cite

Abstract-Growth hormone (GH) can influence left ventricular myocardial growth, structure, and function. The GH secretagogue receptor (GHSR, ghrelin receptor) is known to be involved in GH release and is expressed in the myocardium. We hypothesized that genetic variants within the GHSR are associated with parameters of left ventricular mass (LVM) and geometry. Key Words: ventricular function, left Ⅲ genetics Ⅲ growth substances Ⅲ hypertrophy L eft ventricular (LV) hypertrophy (LVH) constitutes one of the most powerful independent risk factors for cardiovascular morbidity and mortality in high-risk patients and in the general population. 1-3 Its heterogeneous etiology results from the complex interaction among genetic, environmental, and lifestyle factors with hypertension and obesity as principal determinants for this major cardiovascular condition. 4 There is evidence that LV mass (LVM) displays considerable variance in subjects, despite well-comparable environmental and predisposing factors, suggesting a substantial heritable component to the development of LVH. Specifically, 60% of the blood pressure (BP)-independent variation in cardiac mass may be attributable to genetic factors. 5 Moreover, neuroendocrine factors, such as growth hormone (GH), contribute to the determination of cardiac mass and the development of cardiac hypertrophy. 2 In fact, it has been demonstrated in animals and in humans 6 -10 that GH influences LV myocardial growth, structure, and function. GH primarily stimulates the local production of insulin-like growth factor 1, which, in turn, promotes tissue growth by paracrine and autocrine mechanisms. 6,7,11,12 The GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Furthermore, GHSR is expressed in the myocardium, suggesting cardiovascular actions of the receptor and its ligand. [13][14][15][16] In a previous study, we systematically explored the linkage disequilibrium (LD) and haplotype structure of the genomic region encompassing the GHSR gene and demonstrated a significant relationship between common genetic variants of the GHSR and body mass. 17 Here, we comprehensively analyzed whether GHSR also affects LVM and heart size, independent of body mass. We tested the relationship between common single nucleotide poly-

show abstract

“…To eliminate a need of gender-specific LVMI evaluation by indexing LVM for fat-free body mass (FFM), gender-specific equations for the FFM were used as previously described by Kuch et al 22 …”

Section: Fat-free Body Mass Calculationmentioning

confidence: 99%

Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function

et al. 2002

Self Cite

View full text Add to dashboard Cite

Abstract-The G protein ␤ 3 -subunit C825T polymorphism results in a truncated splice variant protein that is associated with enhanced transmembrane signaling, increased proliferative activity, and arterial hypertension. The aim of the present study was to further investigate the association of this polymorphism with left ventricular (LV) structure and function. A total of 2052 individuals from a large-scale population-based sample were investigated for the G protein ␤ 3 -subunit C825T polymorphism and echocardiographic parameters of LV structure and function. Complete genotyping and echocardiographic data were available in 1720 individuals (829 men and 891 women). The mean LV mass indices in men with CC (nϭ384) and TT (nϭ84) genotypes were 98.3Ϯ1.2 g/m 2 and 100.0Ϯ2.8 g/m 2 , respectively (Pϭ0.64). In women, the corresponding values were 83.1Ϯ1.0 g/m 2 for the CC genotype (nϭ397) and 83.8Ϯ2.1 g/m 2 for the TT genotype (nϭ91, Pϭ0.32). Likewise, LV dimensions or parameters of the diastolic function and serologic markers of LV mass were not associated with the C825T variant. Finally, multivariate analyses accounting for potentially confounding factors failed to show any influence of this polymorphism on echocardiographic parameters. In conclusion, we were not able to confirm the previously published associations of the G protein ␤ 3 -subunit C825T polymorphism with LV structure and diastolic function.

show abstract

Indexation of left ventricular mass in adults with a novel approximation for fat-free mass

Cited by 36 publications

References 28 publications

Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques <i>(Macaca radiata)</i>

Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques <i>(Macaca radiata)</i>

Association of the Ghrelin Receptor Gene Region With Left Ventricular Hypertrophy in the General Population

Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function

Contact Info

Product

Resources

About

Indexation of left ventricular mass in adults with a novel approximation for fat-free mass

Cited by 36 publications

References 28 publications

Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques <i>(Macaca radiata)</i>

Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques <i>(Macaca radiata)</i>

Association of the Ghrelin Receptor Gene Region With Left Ventricular Hypertrophy in the General Population

Relation of the G Protein β 3 -Subunit Polymorphism With Left Ventricle Structure and Function

Contact Info

Product

Resources

About

Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function