Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques &lt;i&gt;(Macaca radiata)&lt;/i&gt;

Lazar, Jason; Qureshi, Ghazanfar; Qureshi, Mohammed Rehan; Smith, Eric L.; Scharf, Bruce; Rosenblum, Leonard A.; Signaevsky, Maxim; Kral, John G.; Salciccioli, Louis

doi:10.1159/000176065

Cited by 8 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anesthetic agents are known to influence LV performance and all studies were performed during sedation with ketamine [34]. LVEF was based on measurements from the parasternal view, which was obtained easily in all of the animals given that our laboratory has large experience in imaging this species of monkeys [17]. …”

Section: Discussionmentioning

confidence: 99%

“…Also, although nonhuman primates are used to study cardiovascular disease and aging, measures of vascular function such as the ABI are limited in these animals. Macaques are anatomically similar to humans and exhibit similar cardiovascular physiology and metabolism, which makes them a useful model to study LV-arterial relationships [16,17]. Accordingly, the objective of this study was to determine whether ABI is associated with LV systolic function in nonhuman primates known to have a very low risk of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Ankle-Brachial Index Is Related to Left Ventricular Ejection Fraction in Bonnet Macaques

Liu

Bapat²,

Kamran³

et al. 2015

Cardiology

Self Cite

View full text Add to dashboard Cite

Low ankle-brachial index (ABI) is a marker of peripheral arterial disease associated with higher cardiovascular risk. ABI has been found to be influenced by left ventricular ejection fraction (LVEF), but this relation is confounded by atherosclerosis. Objectives: Since nonhuman primates have a low incidence of atherosclerosis, we sought to evaluate the effect of LVEF on ABI in 24 healthy female bonnet macaques (age 83 ± 21 months). Methods: LVEF was determined by echocardiography during anesthesia with ketamine. ABI was determined using automatic blood pressure cuff. Results: Mean LVEF was 73 ± 6%. Mean ABI was 1.03 (range 0.78-1.17) with similar right and left lower limb values (p = 0.78). On univariate analysis, mean ABI was significantly correlated with LVEF (r = 0.58, p = 0.003) but not with age, crown-rump length or weight. Mean LVEF increased in a stepwise manner from lowest to highest ABI tertile (68 ± 6 vs. 73 ± 4 vs. 77 ± 5%, p = 0.008). On ordinal regression and forced multivariate linear analyses, ABI status was independently related to LVEF. Conclusions: ABI is influenced by left ventricular systolic function but not age, height, weight or mass index in bonnet macaques. Left ventricular systolic function should be accounted for when considering ABI measurements.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Ankle-Brachial Index Is Related to Left Ventricular Ejection Fraction in Bonnet Macaques

Liu

Bapat²,

Kamran³

et al. 2015

Cardiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Both septal and posterior wall thickness were measured at end-diastole. Measurements of RV cavity dimensions were performed from ME two- or four-chamber views, while the LV cavity dimensions were measured from the ME2C view, or from the transthoracic apical view of the LV [38, 44]. The minor axis is taken at the mitral or tricuspid papillary muscle apex level.…”

Section: Methodsmentioning

confidence: 99%

“…Review of the literature reveals only limited use of echocardiography to evaluate cardiac performance in various subhuman primates with an emphasis on transthoracic imaging [15, 23, 36, 37, 29, 22, 31]. For old-world monkeys, the literature emphasis has been macaques rather than baboons [38, 39]. Given that baboons are a better size for intracardiac survival surgery models than macaques, this study was performed to define the utility of transesophageal echocardiography in baboons, to develop reproducible techniques for acquiring the necessary images, to evaluate species specific cardiac anatomy, ventricular and valve performance in young adult Papio hamadryas anubis as compared with analogous images, dimensional and functional data in humans.…”

Section: 0 Introductionmentioning

confidence: 99%

Transesophageal echocardiography in healthy young adult male baboons (Papio hamadryas anubis): Normal cardiac anatomy and function in subhuman primates compared to humans

Bert

Drake

Quinn

et al. 2013

Progress in Pediatric Cardiology

View full text Add to dashboard Cite

Implantable, viable tissue engineered cardiovascular constructs are rapidly approaching clinical translation. Species typically utilized as preclinical large animal models are food stock ungulates for which cross species biological and genomic differences with humans are great. Multiple authorities have recommended developing subhuman primate models for testing regenerative surgical strategies to mitigate xenotransplant inflammation. However, there is a lack of specific quantitative cardiac imaging comparisons between humans and the genomically similar baboons (Papio hamadryas anubis). This study was undertaken to translate to baboons transesophageal echocardiographic functional and dimensional criteria defined as necessary for defining cardiac anatomy and function in the perioperative setting. Seventeen young, healthy baboons (approximately 30 kg, similar to 5 year old children) were studied to determine whether the requisite 11 views and 52 measurement parameters could be reliably acquired by transesophageal echocardiography (TEE). The obtained measurements were compared to human adult normative literature values and to a large relational database of pediatric “normal heart” echo measurements. Comparisons to humans, when normalized to BSA, revealed a trend in baboons toward larger mitral and aortic valve effective orifice areas and much larger left ventricular muscle mass and wall thickness, but similar pulmonary and tricuspid valves. By modifying probe positioning relative to human techniques, all recommended TEE views except transgastric could be replicated. To supplement, two transthoracic apical views were discovered that in baboons could reliably replace the transgastric TEE view. Thus, all requisite echo views could be obtained for a complete cardiac evaluation in Papio hamadryas anubis to noninvasively quantify cardiac structural anatomy, physiology, and dimensions. Despite similarities between the species, there are subtle and important physiologic and anatomic differences when compared to human.

show abstract

“…20,21 Furthermore, peak systolic mitral annular velocity (S¢) was measured and was used as a parameter of LV systolic function. 22,23 Measurement of CAVI and CBP All measurements were conducted in a quiet room kept at a constant temperature. CAVI was recorded using a VaseraVS-1000 vascular screening system (Fukuda Denshi, Tokyo, Japan) with the patient resting in a supine position just after the echocardiographic examination.…”

Section: Echocardiographic Examinationmentioning

confidence: 99%

Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients

et al. 2009

View full text Add to dashboard Cite

Recent automated applanation tonometry can measure radial pulse wave-derived central blood pressure (CBP), which has shown a prognostic value independently of peripheral blood pressure. However, CBP's clinical significance has not been fully established. We examined the associations between CBP and cardiac structure and function by comparing them with those of arterial stiffness assessed by cardio-ankle vascular index (CAVI) in treated hypertensive patients. Enrolled in the study were 102 patients (71 ± 7 years) with treated hypertension. The transmitral early-to-atrial velocity ratio (E/A), peak systolic (S¢), early diastolic (E¢) mitral annular velocities and the Tei index were measured as indexes of cardiac function derived from conventional and tissue Doppler echocardiography. Left ventricular mass index (LVMI) was measured as an index of LV hypertrophy. CBP and CAVI were measured just after echocardiographic examination. CBP, but not CAVI, correlated with LVMI (r¼0.306, Po0.01). Although CBP correlated only with the Tei index (r¼0.201, Po0.05), CAVI correlated with E/A (r¼À0.387, Po0.001), S¢ (r¼À0.270, Po0.01), E¢ (r¼À0.362, Po0.01) and the Tei index (r¼0.339, Po0.01). Stepwise regression analysis revealed that neither CBP nor CAVI was independently associated with E/A, S¢ or E¢. However, CAVI, but not CBP, was independently associated with the Tei index (b coefficient¼0.311, Po0.001), reflecting both LV systolic and diastolic function. In conclusion, CBP may be suitable for detecting LV hypertrophy. In contrast, CAVI may be suitable for detecting LV dysfunction. This difference, suggesting the clinical value of each parameter, should be kept in mind when we use CBP and CAVI for assessing arteriosclerosis in treated hypertension.

show abstract

Left Ventricular Systolic and Diastolic Function in Healthy Adult Bonnet Macaques <i>(Macaca radiata)</i>

Cited by 8 publications

References 31 publications

The Ankle-Brachial Index Is Related to Left Ventricular Ejection Fraction in Bonnet Macaques

The Ankle-Brachial Index Is Related to Left Ventricular Ejection Fraction in Bonnet Macaques

Transesophageal echocardiography in healthy young adult male baboons (Papio hamadryas anubis): Normal cardiac anatomy and function in subhuman primates compared to humans

Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients

Contact Info

Product

Resources

About