Independent relationship between serum ferritin levels and dyslipidemia in Chinese adults: A population study

Abstract

ObjectiveSeveral studies have indicated that elevated levels of circulating ferritin are associated with disturbances in energy metabolism. But none of this gave a clearly pathologic mechanism. We aimed to explore the independent relationship between serum ferritin levels and dyslipidemia.MethodsWe performed multivariable logistic regression analyses to estimate the odds ratios (ORs) for dyslipidemia, lipid parameters, the homeostasis model assessment of insulin resistance (HOMA-IR) and the risk of diabetes, according to sex-specific quartiles of serum ferritin by using the data of China Health and Nutrition Survey (2009 CHNS). We used three models to estimate the strength of the correlation. The basic model (Model 1) is without adjustment and the Model 2 and Model 3 are adjusted for demographic, anthropometric, and lifestyle confounding factors.ResultsIn both genders, the ORs for high TG level, TC level and LDL-C level increased progressively and for HDL-C decreased across the ferritin quartiles (P<0.001 for trend). After adjustment for confounding factors in different logistic regression models, the results remained unchanged. The ORs for the risk of diabetes and high HOMA-IR level in the highest quartile group of serum ferritin levels were significantly increased in Model 1, but after adjustment for lipid parameters, the ORs for the risk of diabetes was decreased from 1.91 (95% CI: 1.37–2.67; P<0.001 for trend) to 1.48 (95% CI: 1.03–2.12; P = 0.036 for trend) in men, and from 5.40 (95% CI: 3.38–8.63; P<0.001 for trend) to 1.43 (95% CI: 0.83–2.43; P = 0.498 for trend) in women, and the ORs for IR was decreased from 1.86 (95% CI: 1.57–2.20; P<0.001 for trend) to 1.25 (95% CI: 1.05–1.50; P = 0.114 for trend) in men, and from 1.93 (95% CI: 1.63–2.28; P<0.001 for trend) to 1.24 (95% CI: 1.01–1.51; P = 0.012 for trend) in women.ConclusionOur results provide evidence that serum ferritin levels are significantly associated with lipid parameters, independent of glucose metabolism disorders and components of metabolic syndrome (MetS). Thus, serum ferritin plays a key role in energy metabolism disorders and may affect glucose metabolism through lipid metabolism.

Coronavirus Persistence on a Plastic Carrier Under Refrigeration Conditions and Its Reduction Using Wet Wiping Technique, with Respect to Food Safety

“…However, according to Mullis et al ( 2012 ), the infectivity of Betacoronavirus 1 on the surface of romaine lettuce under household refrigeration conditions extended to 14 days. Fomite transmission of viral respiratory diseases, including coronaviruses and less persistent viruses, has been previously proven or suspected (Boone and Gerba 2007 ; Xiao et al 2017 ). Those findings support the possibility of COVID-19 spread through food and food packaging.…”

Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey

“…In 2004, Jehn et al showed that SF was positively correlated with elevated TG in 6044 American adults [46]. Recently, Li et al showed SF values were significantly associated with TC, LDL-C, TG, and HDL-C independent of diabetes or IR in a Chinese population in both genders [47]. However, Yoo et al showed that significant associations of high SF with TG and HDL-C in young non-obese adults only existed in women [48].…”

The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-Wide Mendelian Randomization Study

“…Serum ferritin and plasma copper have been associated with an improved blood lipid profile, corresponding to a reduced risk of hyperlipidemia [ 12 , 13 ]. However, conflicting associative patterns have also been reported [ 14 ]. Since most existing studies were observational and often complicated by reverse causality and residual confounding, it is still unknown whether these associations indicate causal relationships.…”